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Upregulation of long noncoding RNA Gadd45a is associated with sevoflurane-induced neurotoxicity in rat neural stem cells.
Neuroreport. 2018 05 23; 29(8):605-614.N

Abstract

Emerging evidence has shown that long noncoding RNA (lncRNA) plays a crucial role in controlling neural stem cells' (NSCs) survival. However, the fundamental role of lncRNA underlying sevoflurane-induced neurotoxicity remains poorly elucidated. In the present study, we investigate the effect of sevoflurane-induced neurotoxicity in a concentration-dependent and duration-dependent manner. Furthermore, we assayed the differential profile of lncRNA in rat hippocampal NSCs following sevoflurane exposure, and identified lncRNA Gadd45a and the correlation between lncRNA Gadd45a and Gadd45a. We found that lncRNA Gadd45a and its nearby gene, Gadd45a, were significantly upregulated in NSCs exposed to sevoflurane. Notably, Gadd45a was enriched in the cell cycle-relative pathway including mitogen-activated protein kinases and P53 signaling, whereas lncRNA Gadd45a was positively correlated with Gadd45a. These results suggest lncRNA Gadd45a is associated with sevoflurane-induced toxicity, and thus shed light on a new key target for revealing the molecular mechanism of sevoflurane-induced toxicity.

Authors+Show Affiliations

Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province. Departments of Anesthesiology.Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province.Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province.Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province.Clinical Laboratory, Fujian Provincial Maternity and Children's Hospital, Fujian Medical University, Fuzhou, Fujian Province, China.Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29521679

Citation

Lu, Guolin, et al. "Upregulation of Long Noncoding RNA Gadd45a Is Associated With Sevoflurane-induced Neurotoxicity in Rat Neural Stem Cells." Neuroreport, vol. 29, no. 8, 2018, pp. 605-614.
Lu G, Xu H, Zhao W, et al. Upregulation of long noncoding RNA Gadd45a is associated with sevoflurane-induced neurotoxicity in rat neural stem cells. Neuroreport. 2018;29(8):605-614.
Lu, G., Xu, H., Zhao, W., Zhang, J., Rao, D., & Xu, S. (2018). Upregulation of long noncoding RNA Gadd45a is associated with sevoflurane-induced neurotoxicity in rat neural stem cells. Neuroreport, 29(8), 605-614. https://doi.org/10.1097/WNR.0000000000000980
Lu G, et al. Upregulation of Long Noncoding RNA Gadd45a Is Associated With Sevoflurane-induced Neurotoxicity in Rat Neural Stem Cells. Neuroreport. 2018 05 23;29(8):605-614. PubMed PMID: 29521679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Upregulation of long noncoding RNA Gadd45a is associated with sevoflurane-induced neurotoxicity in rat neural stem cells. AU - Lu,Guolin, AU - Xu,Huali, AU - Zhao,Wei, AU - Zhang,Jianbo, AU - Rao,Dongdong, AU - Xu,Shiyuan, PY - 2018/3/10/pubmed PY - 2019/4/9/medline PY - 2018/3/10/entrez SP - 605 EP - 614 JF - Neuroreport JO - Neuroreport VL - 29 IS - 8 N2 - Emerging evidence has shown that long noncoding RNA (lncRNA) plays a crucial role in controlling neural stem cells' (NSCs) survival. However, the fundamental role of lncRNA underlying sevoflurane-induced neurotoxicity remains poorly elucidated. In the present study, we investigate the effect of sevoflurane-induced neurotoxicity in a concentration-dependent and duration-dependent manner. Furthermore, we assayed the differential profile of lncRNA in rat hippocampal NSCs following sevoflurane exposure, and identified lncRNA Gadd45a and the correlation between lncRNA Gadd45a and Gadd45a. We found that lncRNA Gadd45a and its nearby gene, Gadd45a, were significantly upregulated in NSCs exposed to sevoflurane. Notably, Gadd45a was enriched in the cell cycle-relative pathway including mitogen-activated protein kinases and P53 signaling, whereas lncRNA Gadd45a was positively correlated with Gadd45a. These results suggest lncRNA Gadd45a is associated with sevoflurane-induced toxicity, and thus shed light on a new key target for revealing the molecular mechanism of sevoflurane-induced toxicity. SN - 1473-558X UR - https://www.unboundmedicine.com/medline/citation/29521679/Upregulation_of_long_noncoding_RNA_Gadd45a_is_associated_with_sevoflurane_induced_neurotoxicity_in_rat_neural_stem_cells_ L2 - https://doi.org/10.1097/WNR.0000000000000980 DB - PRIME DP - Unbound Medicine ER -