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The role of fish intake on asthma in children: A meta-analysis of observational studies.

Abstract

BACKGROUND

The evidence is mixed on the use of long chain Omega-3 fatty acids in the prevention and management of childhood asthma.

METHODS

We conducted a systematic search and meta-analysis investigating the role of fish intake, the main dietary source of long chain omega-3 fatty acids, on asthma in children.

RESULTS

A total of 1119 publications were identified. Twenty-three studies on fish intake in association with childhood asthma were included in the final review. In 15 of 23 studies, early introduction of fish (6-9 months) and regular consumption (at least once a week) improved asthma symptoms and reduced risk in children 0-14 years as compared to no fish consumption; 6 of 23 showed no effect and 2 of 23 studies suggest adverse effects. Meta-analysis revealed an overall "beneficial effect" for "all fish" intake on "current asthma" [OR: 0.75; 95%CI: 0.60-0.95] and "current wheeze" [OR: 0.62; 95%CI: 0.48-0.80] in children up to 4.5 years old. An overall protective effect of "fatty fish" intake as compared to "no fish" intake in children 8-14 years old was also observed [OR: 0.35; 95%CI: 0.18-0.67].

CONCLUSION

This meta-analysis suggests that introduction of fish early in life (6-9 months) and regular consumption of all fish (at least once a week) reduces asthma and wheeze in children up to 4.5 years old, while fatty fish intake may be beneficial in older children. Future well-designed clinical trials are recommended to confirm the promising findings documented in this literature analysis.

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  • Authors+Show Affiliations

    ,

    Department of Rehabilitation, Nutrition and Sport, School of Allied Health, La Trobe University, Melbourne, VIC, Australia.

    ,

    Research Centre for Integrated Development (RECID), Nepal, Nepal.

    ,

    Department of Rehabilitation, Nutrition and Sport, School of Allied Health, La Trobe University, Melbourne, VIC, Australia.

    School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.

    Source

    MeSH

    Adolescent
    Asthma
    Child
    Child, Preschool
    Diet
    Humans
    Infant
    Infant, Newborn
    Observational Studies as Topic
    Protective Factors
    Seafood

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    29524247

    Citation

    Papamichael, M M., et al. "The Role of Fish Intake On Asthma in Children: a Meta-analysis of Observational Studies." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 29, no. 4, 2018, pp. 350-360.
    Papamichael MM, Shrestha SK, Itsiopoulos C, et al. The role of fish intake on asthma in children: A meta-analysis of observational studies. Pediatr Allergy Immunol. 2018;29(4):350-360.
    Papamichael, M. M., Shrestha, S. K., Itsiopoulos, C., & Erbas, B. (2018). The role of fish intake on asthma in children: A meta-analysis of observational studies. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 29(4), pp. 350-360. doi:10.1111/pai.12889.
    Papamichael MM, et al. The Role of Fish Intake On Asthma in Children: a Meta-analysis of Observational Studies. Pediatr Allergy Immunol. 2018;29(4):350-360. PubMed PMID: 29524247.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The role of fish intake on asthma in children: A meta-analysis of observational studies. AU - Papamichael,M M, AU - Shrestha,S K, AU - Itsiopoulos,C, AU - Erbas,B, PY - 2018/03/05/accepted PY - 2018/3/11/pubmed PY - 2018/11/27/medline PY - 2018/3/11/entrez KW - Omega-3 fatty acids KW - asthma KW - children KW - fish KW - nutrition KW - oily fish SP - 350 EP - 360 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 29 IS - 4 N2 - BACKGROUND: The evidence is mixed on the use of long chain Omega-3 fatty acids in the prevention and management of childhood asthma. METHODS: We conducted a systematic search and meta-analysis investigating the role of fish intake, the main dietary source of long chain omega-3 fatty acids, on asthma in children. RESULTS: A total of 1119 publications were identified. Twenty-three studies on fish intake in association with childhood asthma were included in the final review. In 15 of 23 studies, early introduction of fish (6-9 months) and regular consumption (at least once a week) improved asthma symptoms and reduced risk in children 0-14 years as compared to no fish consumption; 6 of 23 showed no effect and 2 of 23 studies suggest adverse effects. Meta-analysis revealed an overall "beneficial effect" for "all fish" intake on "current asthma" [OR: 0.75; 95%CI: 0.60-0.95] and "current wheeze" [OR: 0.62; 95%CI: 0.48-0.80] in children up to 4.5 years old. An overall protective effect of "fatty fish" intake as compared to "no fish" intake in children 8-14 years old was also observed [OR: 0.35; 95%CI: 0.18-0.67]. CONCLUSION: This meta-analysis suggests that introduction of fish early in life (6-9 months) and regular consumption of all fish (at least once a week) reduces asthma and wheeze in children up to 4.5 years old, while fatty fish intake may be beneficial in older children. Future well-designed clinical trials are recommended to confirm the promising findings documented in this literature analysis. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/29524247/The_role_of_fish_intake_on_asthma_in_children:_A_meta_analysis_of_observational_studies_ L2 - https://doi.org/10.1111/pai.12889 DB - PRIME DP - Unbound Medicine ER -