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Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan.
Endocr J. 2018 Jun 27; 65(6):593-599.EJ

Abstract

There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia for 3 years was sent to 855 randomly selected hospitals with a pediatrics department in Japan. In this survey, we found that 250 children were diagnosed with symptomatic vitamin D deficiency. The estimated number of patients with symptomatic vitamin D deficiency per year was 183 (95% confidence interval (CI): 145-222). The overall annual incidence rate among children under 15 years of age was 1.1 per 100,000 population (95% CI: 0.9-1.4). The second survey has provided detailed information on 89 patients with symptomatic vitamin D deficiency under 5 years of age in hospitals in the current research group. The nationwide and second surveys estimated the overall annual incidence rate of symptomatic vitamin D deficiency in children under 5 years of age to be 3.5 (2.7-4.2) per 100,000 population. The second survey revealed 83% had bowed legs, 88% had exclusive breastfeeding, 49% had a restricted and/or unbalanced diet and 31% had insufficient sun exposure among the 89 patients. This is the first nationwide survey on definitive clinical vitamin D deficiency in children in Japan. Elucidating the frequency and characteristics of symptomatic vitamin D deficiency among children is useful to develop preventative public health strategies.

Authors+Show Affiliations

Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Public Health, Jichi Medical University, Tochigi 329-0498, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima 770-8503, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatric Endocrinology and Environmental Medicine, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo 183-8561, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Oita University Faculty of Medicine, Oita 879-5593, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Dokkyo Medical University, Tochigi 321-0293, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Kyorin University, Tokyo 181-0004, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Aichi 467-8602, Japan. Department of Pediatrics, International University of Health and Welfare, School of Medicine, Chiba 286-8686, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8520, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Orthopedics, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Asahikawa Medical University, Hokkaido 078-8510, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Okayama University Hospital, Okayama 700-8558, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Division of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka 594-1101, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29526992

Citation

Kubota, Takuo, et al. "Incidence Rate and Characteristics of Symptomatic Vitamin D Deficiency in Children: a Nationwide Survey in Japan." Endocrine Journal, vol. 65, no. 6, 2018, pp. 593-599.
Kubota T, Nakayama H, Kitaoka T, et al. Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan. Endocr J. 2018;65(6):593-599.
Kubota, T., Nakayama, H., Kitaoka, T., Nakamura, Y., Fukumoto, S., Fujiwara, I., Hasegawa, Y., Ihara, K., Kitanaka, S., Koyama, S., Kusuda, S., Mizuno, H., Nagasaki, K., Oba, K., Sakamoto, Y., Takubo, N., Shimizu, T., Tanahashi, Y., Hasegawa, K., ... Ozono, K. (2018). Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan. Endocrine Journal, 65(6), 593-599. https://doi.org/10.1507/endocrj.EJ18-0008
Kubota T, et al. Incidence Rate and Characteristics of Symptomatic Vitamin D Deficiency in Children: a Nationwide Survey in Japan. Endocr J. 2018 Jun 27;65(6):593-599. PubMed PMID: 29526992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan. AU - Kubota,Takuo, AU - Nakayama,Hirofumi, AU - Kitaoka,Taichi, AU - Nakamura,Yosikazu, AU - Fukumoto,Seiji, AU - Fujiwara,Ikuma, AU - Hasegawa,Yukihiro, AU - Ihara,Kenji, AU - Kitanaka,Sachiko, AU - Koyama,Satomi, AU - Kusuda,Satoshi, AU - Mizuno,Haruo, AU - Nagasaki,Keisuke, AU - Oba,Koji, AU - Sakamoto,Yuko, AU - Takubo,Noriyuki, AU - Shimizu,Toshiaki, AU - Tanahashi,Yusuke, AU - Hasegawa,Kosei, AU - Tsukahara,Hirokazu, AU - Yorifuji,Tohru, AU - Michigami,Toshimi, AU - Ozono,Keiichi, Y1 - 2018/03/10/ PY - 2018/3/13/pubmed PY - 2018/10/26/medline PY - 2018/3/13/entrez KW - Children KW - Hypocalcemia KW - Nationwide survey KW - Rickets KW - Vitamin D deficiency SP - 593 EP - 599 JF - Endocrine journal JO - Endocr. J. VL - 65 IS - 6 N2 - There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia for 3 years was sent to 855 randomly selected hospitals with a pediatrics department in Japan. In this survey, we found that 250 children were diagnosed with symptomatic vitamin D deficiency. The estimated number of patients with symptomatic vitamin D deficiency per year was 183 (95% confidence interval (CI): 145-222). The overall annual incidence rate among children under 15 years of age was 1.1 per 100,000 population (95% CI: 0.9-1.4). The second survey has provided detailed information on 89 patients with symptomatic vitamin D deficiency under 5 years of age in hospitals in the current research group. The nationwide and second surveys estimated the overall annual incidence rate of symptomatic vitamin D deficiency in children under 5 years of age to be 3.5 (2.7-4.2) per 100,000 population. The second survey revealed 83% had bowed legs, 88% had exclusive breastfeeding, 49% had a restricted and/or unbalanced diet and 31% had insufficient sun exposure among the 89 patients. This is the first nationwide survey on definitive clinical vitamin D deficiency in children in Japan. Elucidating the frequency and characteristics of symptomatic vitamin D deficiency among children is useful to develop preventative public health strategies. SN - 1348-4540 UR - https://www.unboundmedicine.com/medline/citation/29526992/Incidence_rate_and_characteristics_of_symptomatic_vitamin_D_deficiency_in_children:_a_nationwide_survey_in_Japan_ L2 - https://dx.doi.org/10.1507/endocrj.EJ18-0008 DB - PRIME DP - Unbound Medicine ER -