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Relevance of 25 (OH) Vitamin D deficiency on Hashimoto's Thyroiditis.
Egypt J Immunol. 2017 Jun; 24(2):53-62.EJ

Abstract

An association between low levels of vitamin D and Hashimoto's thyroiditis was suggested. This study aimed to determine the status of 25 (OH) vitamin D in Hashimoto's thyroiditis. A case-control study was designed, a Hashimoto's thyroiditis patient group (n=30) and two control groups including Graves' disease (30) and a healthy control group (20). TSH, Free T3, Free T4, antithyroid antibodies (antithyroglobulin and antithyroid peroxidase), calcium and serum 25 (OH) vitamin D were assessed. Vitamin D and calcium levels were significantly lower in Hashimoto thyroiditis and Graves' disease versus healthy controls. Vitamin D was deficient in 76.7% of Hashimoto thyroiditis and 70% of Graves' disease compared to 20.0% of healthy control, and negatively correlated with antithyroglobulin and antithyroid peroxidase in Hashimoto's thyroiditis group. Vitamin D is recommended for patients with vitamin D deficiency. Further investigations are needed to evaluate the preventive and therapeutic effects of vitamin D in autoimmune thyroid disease.

Authors+Show Affiliations

Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29528579

Citation

Bakr, Hoda G., and Takwa E. Meawed. "Relevance of 25 (OH) Vitamin D Deficiency On Hashimoto's Thyroiditis." The Egyptian Journal of Immunology, vol. 24, no. 2, 2017, pp. 53-62.
Bakr HG, Meawed TE. Relevance of 25 (OH) Vitamin D deficiency on Hashimoto's Thyroiditis. Egypt J Immunol. 2017;24(2):53-62.
Bakr, H. G., & Meawed, T. E. (2017). Relevance of 25 (OH) Vitamin D deficiency on Hashimoto's Thyroiditis. The Egyptian Journal of Immunology, 24(2), 53-62.
Bakr HG, Meawed TE. Relevance of 25 (OH) Vitamin D Deficiency On Hashimoto's Thyroiditis. Egypt J Immunol. 2017;24(2):53-62. PubMed PMID: 29528579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relevance of 25 (OH) Vitamin D deficiency on Hashimoto's Thyroiditis. AU - Bakr,Hoda G, AU - Meawed,Takwa E, PY - 2018/3/13/entrez PY - 2018/3/13/pubmed PY - 2019/4/27/medline SP - 53 EP - 62 JF - The Egyptian journal of immunology JO - Egypt J Immunol VL - 24 IS - 2 N2 - An association between low levels of vitamin D and Hashimoto's thyroiditis was suggested. This study aimed to determine the status of 25 (OH) vitamin D in Hashimoto's thyroiditis. A case-control study was designed, a Hashimoto's thyroiditis patient group (n=30) and two control groups including Graves' disease (30) and a healthy control group (20). TSH, Free T3, Free T4, antithyroid antibodies (antithyroglobulin and antithyroid peroxidase), calcium and serum 25 (OH) vitamin D were assessed. Vitamin D and calcium levels were significantly lower in Hashimoto thyroiditis and Graves' disease versus healthy controls. Vitamin D was deficient in 76.7% of Hashimoto thyroiditis and 70% of Graves' disease compared to 20.0% of healthy control, and negatively correlated with antithyroglobulin and antithyroid peroxidase in Hashimoto's thyroiditis group. Vitamin D is recommended for patients with vitamin D deficiency. Further investigations are needed to evaluate the preventive and therapeutic effects of vitamin D in autoimmune thyroid disease. SN - 1110-4902 UR - https://www.unboundmedicine.com/medline/citation/29528579/Relevance_of_25__OH__Vitamin_D_deficiency_on_Hashimoto's_Thyroiditis_ L2 - https://medlineplus.gov/vitaminddeficiency.html DB - PRIME DP - Unbound Medicine ER -
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