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Vasoactive androgens: Vasorelaxing effects and their potential regulation of blood pressure.
Endocr Res 2018; 43(3):166-175ER

Abstract

BACKGROUND

Testosterone, 5α- and 5β-dihydrotestosterone (-DHT) induce an acute in vitro vasorelaxation and in vivo vasodepressor, hypotensive and antihypertensive responses. Our aim was to study whether androgen-induced blood pressure (BP) reduction is involved with a blockade of Ca2+ influx through L-type voltage-operated calcium channels (L-VOCCs) and/or the signaling pathways of α1-adrenoceptors to induce vasoconstriction, which are one of the major mechanisms of BP maintenance.

MATERIALS AND METHODS

The relaxing potency and efficacy of each androgen in large conduit (thoracic aorta) and resistance (mesenteric) arteries from male hypertensive (SHR) and normotensive (WKY) rats were established. Blood vessels were isometrically recorded and precontracted with KCl or phenylephrine (Phe).

RESULTS

Androgens induced concentration-dependent vasorelaxation in precontracted arteries from SHR and WKY rats. 5β-DHT was always the most potent vasorelaxant in arteries from SHR. The KCl-induced contraction resulted significantly more sensitive to androgen-induced vasorelaxation than the Phe-induced contraction. On Phe-induced contraction, 5β-DHT was more potent in the mesenteric artery than in the thoracic aorta.

CONCLUSIONS

The vasorelaxation induced by androgens is mainly mediated by blocking L-VOCCs and in lesser extent by the blockade of multiple signaling pathways operative during α-adrenoceptor-induced vasoconstriction. 5β-DHT regulates vascular resistance and BP by mainly acting in the mesenteric arterial bed, which may explain its outstanding antihypertensive response previously reported.

Authors+Show Affiliations

a Departamento de Fisiología, Facultad de Medicina , Universidad Autónoma de Madrid , Madrid , Spain. b Instituto de Investigaciones Biomédicas, Departamento de Biología Celular y Fisiología , Universidad Nacional Autónoma de México , Mexico City , Mexico.a Departamento de Fisiología, Facultad de Medicina , Universidad Autónoma de Madrid , Madrid , Spain.b Instituto de Investigaciones Biomédicas, Departamento de Biología Celular y Fisiología , Universidad Nacional Autónoma de México , Mexico City , Mexico.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29528756

Citation

Isidoro, Lucía, et al. "Vasoactive Androgens: Vasorelaxing Effects and Their Potential Regulation of Blood Pressure." Endocrine Research, vol. 43, no. 3, 2018, pp. 166-175.
Isidoro L, Ferrer M, Perusquía M. Vasoactive androgens: Vasorelaxing effects and their potential regulation of blood pressure. Endocr Res. 2018;43(3):166-175.
Isidoro, L., Ferrer, M., & Perusquía, M. (2018). Vasoactive androgens: Vasorelaxing effects and their potential regulation of blood pressure. Endocrine Research, 43(3), pp. 166-175. doi:10.1080/07435800.2018.1448868.
Isidoro L, Ferrer M, Perusquía M. Vasoactive Androgens: Vasorelaxing Effects and Their Potential Regulation of Blood Pressure. Endocr Res. 2018;43(3):166-175. PubMed PMID: 29528756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasoactive androgens: Vasorelaxing effects and their potential regulation of blood pressure. AU - Isidoro,Lucía, AU - Ferrer,Mercedes, AU - Perusquía,Mercedes, Y1 - 2018/03/12/ PY - 2018/3/13/pubmed PY - 2018/11/10/medline PY - 2018/3/13/entrez KW - 5β-dihydrotestosterone KW - hypertension KW - nongenomic action KW - testosterone KW - vasorelaxation SP - 166 EP - 175 JF - Endocrine research JO - Endocr. Res. VL - 43 IS - 3 N2 - BACKGROUND: Testosterone, 5α- and 5β-dihydrotestosterone (-DHT) induce an acute in vitro vasorelaxation and in vivo vasodepressor, hypotensive and antihypertensive responses. Our aim was to study whether androgen-induced blood pressure (BP) reduction is involved with a blockade of Ca2+ influx through L-type voltage-operated calcium channels (L-VOCCs) and/or the signaling pathways of α1-adrenoceptors to induce vasoconstriction, which are one of the major mechanisms of BP maintenance. MATERIALS AND METHODS: The relaxing potency and efficacy of each androgen in large conduit (thoracic aorta) and resistance (mesenteric) arteries from male hypertensive (SHR) and normotensive (WKY) rats were established. Blood vessels were isometrically recorded and precontracted with KCl or phenylephrine (Phe). RESULTS: Androgens induced concentration-dependent vasorelaxation in precontracted arteries from SHR and WKY rats. 5β-DHT was always the most potent vasorelaxant in arteries from SHR. The KCl-induced contraction resulted significantly more sensitive to androgen-induced vasorelaxation than the Phe-induced contraction. On Phe-induced contraction, 5β-DHT was more potent in the mesenteric artery than in the thoracic aorta. CONCLUSIONS: The vasorelaxation induced by androgens is mainly mediated by blocking L-VOCCs and in lesser extent by the blockade of multiple signaling pathways operative during α-adrenoceptor-induced vasoconstriction. 5β-DHT regulates vascular resistance and BP by mainly acting in the mesenteric arterial bed, which may explain its outstanding antihypertensive response previously reported. SN - 1532-4206 UR - https://www.unboundmedicine.com/medline/citation/29528756/Vasoactive_androgens:_Vasorelaxing_effects_and_their_potential_regulation_of_blood_pressure_ L2 - http://www.tandfonline.com/doi/full/10.1080/07435800.2018.1448868 DB - PRIME DP - Unbound Medicine ER -