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UCP2 and UCP3 variants and gene-environment interaction associated with prediabetes and T2DM in a rural population: a case control study in China.
BMC Med Genet 2018; 19(1):43BM

Abstract

BACKGROUND

There are disparities for the association between uncoupling proteins (UCP) and type 2 diabetes (T2DM). The study was to examine the associations of genetic variants of UCP2 and UCP3 with prediabetes and T2DM in a rural Chinese population.

METHODS

A population-based case-control study of 397 adults with T2DM, 394 with prediabetes and 409 with normal glucose tolerance (NGT) was carried out in 2014 in a rural community in eastern China. Three groups were identified through a community survey and the prediabetes and NGT groups were frequently matched by age and gender with the T2DM group and they were not relatives of T2DM subjects. With r2 ≥ 0.8 and minor allele frequency (MAF) ≥0.05 for tag single nucleotide polymorphisms (SNPs) with potential function, three (rs660339, rs45560234 and rs643064) and six (rs7930460, rs15763, rs647126, rs1800849, rs3781907 and rs1685356) SNPs were selected respectively for UCP2 and UCP3 and genotyped in real time using the MassARRAY system (Sequenom; USA). The haplotypes, gene-environmental interaction and association between genetic variants of UCP2 and UCP3 and prediabetes or T2DM were explored.

RESULTS

There were no significant differences in age and sex among three study groups. After the adjustment for possible covariates, the A allele of rs1800849 in UCP3 was significantly associated with prediabetes (aORAA vs GG = 1.68, 95% CI: 1.02-2.78), and the association was also significant under the recessive model (aOR AA vs GA + GG = 1.64, 95% CI: 1.02-2.66). Also, rs15763 was found to be marginally significantly associated with T2DM under dominant model (ORGA + AA vs GG = 0.73, 95% CI: 0.52-1.03, P = 0.072). No haplotype was significantly associated with prediabetes or T2DM. Multiplicative interactions for rs660339-overweight on T2DM were observed. In addition, the AA genotype of rs660339 was associated with an increased risk of T2DM in overweight subjects (OR = 1.48, 95%CI: 0.87-2.52) but with a decreased risk in those with normal weight (OR = 0.54, 95%CI: 0.28-1.05).

CONCLUSIONS

Rs1800849 in UCP3 was significantly associated with prediabetes. Overweight might modify the effects of rs660339 of UCP2 on T2DM.

Authors+Show Affiliations

Yuhuan County Center for Disease Control and Prevention, Yuhuan, Zhejiang Province, 317600, China.School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Xuhui District, Shanghai, 200032, China.School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1G 5Z3, Canada.School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Xuhui District, Shanghai, 200032, China.Yuhuan County Center for Disease Control and Prevention, Yuhuan, Zhejiang Province, 317600, China.Yuhuan County Center for Disease Control and Prevention, Yuhuan, Zhejiang Province, 317600, China.School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Xuhui District, Shanghai, 200032, China.School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Xuhui District, Shanghai, 200032, China.School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Xuhui District, Shanghai, 200032, China.School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Xuhui District, Shanghai, 200032, China. fcw@fudan.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29529994

Citation

Su, Meifang, et al. "UCP2 and UCP3 Variants and Gene-environment Interaction Associated With Prediabetes and T2DM in a Rural Population: a Case Control Study in China." BMC Medical Genetics, vol. 19, no. 1, 2018, p. 43.
Su M, Chen X, Chen Y, et al. UCP2 and UCP3 variants and gene-environment interaction associated with prediabetes and T2DM in a rural population: a case control study in China. BMC Med Genet. 2018;19(1):43.
Su, M., Chen, X., Chen, Y., Wang, C., Li, S., Ying, X., ... Fu, C. (2018). UCP2 and UCP3 variants and gene-environment interaction associated with prediabetes and T2DM in a rural population: a case control study in China. BMC Medical Genetics, 19(1), p. 43. doi:10.1186/s12881-018-0554-4.
Su M, et al. UCP2 and UCP3 Variants and Gene-environment Interaction Associated With Prediabetes and T2DM in a Rural Population: a Case Control Study in China. BMC Med Genet. 2018 03 12;19(1):43. PubMed PMID: 29529994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - UCP2 and UCP3 variants and gene-environment interaction associated with prediabetes and T2DM in a rural population: a case control study in China. AU - Su,Meifang, AU - Chen,Xiaoying, AU - Chen,Yue, AU - Wang,Congyun, AU - Li,Songtao, AU - Ying,Xuhua, AU - Xiao,Tian, AU - Wang,Na, AU - Jiang,Qingwu, AU - Fu,Chaowei, Y1 - 2018/03/12/ PY - 2017/04/13/received PY - 2018/02/27/accepted PY - 2018/3/14/entrez PY - 2018/3/14/pubmed PY - 2018/12/14/medline KW - China KW - Gene polymorphism KW - Interaction KW - Prediabetes KW - Type 2 diabetes KW - Uncoupling protein gene SP - 43 EP - 43 JF - BMC medical genetics JO - BMC Med. Genet. VL - 19 IS - 1 N2 - BACKGROUND: There are disparities for the association between uncoupling proteins (UCP) and type 2 diabetes (T2DM). The study was to examine the associations of genetic variants of UCP2 and UCP3 with prediabetes and T2DM in a rural Chinese population. METHODS: A population-based case-control study of 397 adults with T2DM, 394 with prediabetes and 409 with normal glucose tolerance (NGT) was carried out in 2014 in a rural community in eastern China. Three groups were identified through a community survey and the prediabetes and NGT groups were frequently matched by age and gender with the T2DM group and they were not relatives of T2DM subjects. With r2 ≥ 0.8 and minor allele frequency (MAF) ≥0.05 for tag single nucleotide polymorphisms (SNPs) with potential function, three (rs660339, rs45560234 and rs643064) and six (rs7930460, rs15763, rs647126, rs1800849, rs3781907 and rs1685356) SNPs were selected respectively for UCP2 and UCP3 and genotyped in real time using the MassARRAY system (Sequenom; USA). The haplotypes, gene-environmental interaction and association between genetic variants of UCP2 and UCP3 and prediabetes or T2DM were explored. RESULTS: There were no significant differences in age and sex among three study groups. After the adjustment for possible covariates, the A allele of rs1800849 in UCP3 was significantly associated with prediabetes (aORAA vs GG = 1.68, 95% CI: 1.02-2.78), and the association was also significant under the recessive model (aOR AA vs GA + GG = 1.64, 95% CI: 1.02-2.66). Also, rs15763 was found to be marginally significantly associated with T2DM under dominant model (ORGA + AA vs GG = 0.73, 95% CI: 0.52-1.03, P = 0.072). No haplotype was significantly associated with prediabetes or T2DM. Multiplicative interactions for rs660339-overweight on T2DM were observed. In addition, the AA genotype of rs660339 was associated with an increased risk of T2DM in overweight subjects (OR = 1.48, 95%CI: 0.87-2.52) but with a decreased risk in those with normal weight (OR = 0.54, 95%CI: 0.28-1.05). CONCLUSIONS: Rs1800849 in UCP3 was significantly associated with prediabetes. Overweight might modify the effects of rs660339 of UCP2 on T2DM. SN - 1471-2350 UR - https://www.unboundmedicine.com/medline/citation/29529994/UCP2_and_UCP3_variants_and_gene_environment_interaction_associated_with_prediabetes_and_T2DM_in_a_rural_population:_a_case_control_study_in_China_ L2 - https://bmcmedgenet.biomedcentral.com/articles/10.1186/s12881-018-0554-4 DB - PRIME DP - Unbound Medicine ER -