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Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.
Int J Mol Sci. 2018 Mar 13; 19(3)IJ

Abstract

The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada. zoeslong@gmail.com.Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada. ujkumar@mail.ubc.ca.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29533978

Citation

Zou, Shenglong, and Ujendra Kumar. "Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System." International Journal of Molecular Sciences, vol. 19, no. 3, 2018.
Zou S, Kumar U. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. Int J Mol Sci. 2018;19(3).
Zou, S., & Kumar, U. (2018). Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. International Journal of Molecular Sciences, 19(3). https://doi.org/10.3390/ijms19030833
Zou S, Kumar U. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. Int J Mol Sci. 2018 Mar 13;19(3) PubMed PMID: 29533978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. AU - Zou,Shenglong, AU - Kumar,Ujendra, Y1 - 2018/03/13/ PY - 2018/02/09/received PY - 2018/03/10/revised PY - 2018/03/11/accepted PY - 2018/3/14/entrez PY - 2018/3/14/pubmed PY - 2018/8/28/medline KW - cannabinoid KW - central nervous system KW - endocannabinoid KW - receptor KW - signaling JF - International journal of molecular sciences JO - Int J Mol Sci VL - 19 IS - 3 N2 - The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/29533978/Cannabinoid_Receptors_and_the_Endocannabinoid_System:_Signaling_and_Function_in_the_Central_Nervous_System_ L2 - http://www.mdpi.com/resolver?pii=ijms19030833 DB - PRIME DP - Unbound Medicine ER -