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Prospective study of flavonoid intake and risk of primary open-angle glaucoma.
Acta Ophthalmol 2018; 96(6):e692-e700AO

Abstract

PURPOSE

To evaluate the association between flavonoid intake and incident primary open-angle glaucoma (POAG).

METHODS

We followed 65 516 women from the Nurses' Health Study (from 1984) and 42 156 men from the Health Professionals Follow-up Study (from 1986) biennially to 2012, who were 40+ years old, free of POAG, and reported eye examinations. Dietary flavonoid intake was assessed with validated repeated semi-quantitative food frequency questionnaires. Incident POAG cases (n = 1575) were confirmed with medical record review. Cohort-specific multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) were calculated and meta-analysed.

RESULTS

Total flavonoid intake was not associated with risk of POAG development [RR for highest (Q5: median ~645 mg/day) versus lowest quintile (Q1: ~130 mg/day) = 0.91 (95% CI = 0.77, 1.08); p for trend (p-trend) = 0.19]; the flavonoid subclasses of flavones, flavanones, polymeric flavanols or anthocyanidins were also not associated (Q5 versus Q1 comparison p-values ≥0.05 and p-trend ≥0.09). Higher intakes of flavonols and monomeric flavanols were nominally associated with lower POAG risk, based on the Q5 versus Q1 comparisons or p-trends. The Q5 versus Q1 comparison RRs were: for flavonols, 0.82 (95% CI = 0.69, 0.97; p-trend = 0.05; ~28 versus ~8 mg/day), and for monomeric flavanols, 0.86 (95% CI = 0.72, 1.02; p-trend=0.04; ~110 versus 10 mg/day). The food/beverage that contributed most to both the variation of flavonols and monomeric flavanols was tea; consuming ~2 cups/day was associated with 18% lower POAG risk (RR=0.82; 95% CI = 0.68, 0.99; p-trend = 0.02).

CONCLUSION

Total flavonoid intake was not associated with POAG risk. Greater intakes of flavonols and monomeric flavanols and of tea showed suggestive modest associations with lower risk; these results need confirmation.

Authors+Show Affiliations

Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital/Harvard Medical School, Boston, MA, USA.Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA. South Australian Health and Medical Research Institute, Infection and Immunity Theme, School of Medicine, Flinders University, Adelaide, SA, Australia.Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital/Harvard Medical School, Boston, MA, USA. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital/Harvard Medical School, Boston, MA, USA. Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29536641

Citation

Kang, Jae H., et al. "Prospective Study of Flavonoid Intake and Risk of Primary Open-angle Glaucoma." Acta Ophthalmologica, vol. 96, no. 6, 2018, pp. e692-e700.
Kang JH, Ivey KL, Boumenna T, et al. Prospective study of flavonoid intake and risk of primary open-angle glaucoma. Acta Ophthalmol. 2018;96(6):e692-e700.
Kang, J. H., Ivey, K. L., Boumenna, T., Rosner, B., Wiggs, J. L., & Pasquale, L. R. (2018). Prospective study of flavonoid intake and risk of primary open-angle glaucoma. Acta Ophthalmologica, 96(6), pp. e692-e700. doi:10.1111/aos.13705.
Kang JH, et al. Prospective Study of Flavonoid Intake and Risk of Primary Open-angle Glaucoma. Acta Ophthalmol. 2018;96(6):e692-e700. PubMed PMID: 29536641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of flavonoid intake and risk of primary open-angle glaucoma. AU - Kang,Jae H, AU - Ivey,Kerry L, AU - Boumenna,Tahani, AU - Rosner,Bernard, AU - Wiggs,Janey L, AU - Pasquale,Louis R, Y1 - 2018/03/14/ PY - 2017/05/02/received PY - 2017/12/14/accepted PY - 2018/3/15/pubmed PY - 2018/10/26/medline PY - 2018/3/15/entrez KW - cohort KW - epidemiology KW - flavonoids KW - glaucoma SP - e692 EP - e700 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 96 IS - 6 N2 - PURPOSE: To evaluate the association between flavonoid intake and incident primary open-angle glaucoma (POAG). METHODS: We followed 65 516 women from the Nurses' Health Study (from 1984) and 42 156 men from the Health Professionals Follow-up Study (from 1986) biennially to 2012, who were 40+ years old, free of POAG, and reported eye examinations. Dietary flavonoid intake was assessed with validated repeated semi-quantitative food frequency questionnaires. Incident POAG cases (n = 1575) were confirmed with medical record review. Cohort-specific multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) were calculated and meta-analysed. RESULTS: Total flavonoid intake was not associated with risk of POAG development [RR for highest (Q5: median ~645 mg/day) versus lowest quintile (Q1: ~130 mg/day) = 0.91 (95% CI = 0.77, 1.08); p for trend (p-trend) = 0.19]; the flavonoid subclasses of flavones, flavanones, polymeric flavanols or anthocyanidins were also not associated (Q5 versus Q1 comparison p-values ≥0.05 and p-trend ≥0.09). Higher intakes of flavonols and monomeric flavanols were nominally associated with lower POAG risk, based on the Q5 versus Q1 comparisons or p-trends. The Q5 versus Q1 comparison RRs were: for flavonols, 0.82 (95% CI = 0.69, 0.97; p-trend = 0.05; ~28 versus ~8 mg/day), and for monomeric flavanols, 0.86 (95% CI = 0.72, 1.02; p-trend=0.04; ~110 versus 10 mg/day). The food/beverage that contributed most to both the variation of flavonols and monomeric flavanols was tea; consuming ~2 cups/day was associated with 18% lower POAG risk (RR=0.82; 95% CI = 0.68, 0.99; p-trend = 0.02). CONCLUSION: Total flavonoid intake was not associated with POAG risk. Greater intakes of flavonols and monomeric flavanols and of tea showed suggestive modest associations with lower risk; these results need confirmation. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/29536641/Prospective_study_of_flavonoid_intake_and_risk_of_primary_open_angle_glaucoma_ L2 - https://doi.org/10.1111/aos.13705 DB - PRIME DP - Unbound Medicine ER -