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Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops.
Molecules. 2018 Mar 15; 23(3)M

Abstract

Hop (Humulus lupulus L.), as a key ingredient for beer brewing, is also a source of many biologically active molecules. A notable compound, 8-prenylnaringenin (8-PN), structurally belonging to the group of prenylated flavonoids, was shown to be a potent phytoestrogen, and thus, became the topic of active research. Here, we overview the pharmacological properties of 8-PN and its therapeutic opportunities. Due to its estrogenic effects, administration of 8-PN represents a novel therapeutic approach to the treatment of menopausal and post-menopausal symptoms that occur as a consequence of a progressive decline in hormone levels in women. Application of 8-PN in the treatment of menopause has been clinically examined with promising results. Other activities that have already been assessed include the potential to prevent bone-resorption or inhibition of tumor growth. On the other hand, the use of phytoestrogens is frequently questioned regarding possible adverse effects associated with long-term consumption. In conclusion, we emphasize the implications of using 8-PN in future treatments of menopausal and post-menopausal symptoms, including the need for precise evidence and further investigations to define the safety risks related to its therapeutic use.

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Authors+Show Affiliations

Štulíková K
Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. stulikoa@vscht.cz.
Karabín M
Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. marcel.karabin@vscht.cz.
Nešpor J
Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. nesporj@vscht.cz.
Dostálek P
Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. pavel.dostalek@vscht.cz.

MeSH

Antineoplastic Agents, PhytogenicFemaleFlavanonesHumansHumulusMenopauseMolecular StructureOsteoporosis, PostmenopausalPhytoestrogens

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29543713

Citation

Štulíková, Kateřina, et al. "Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen From Hops." Molecules (Basel, Switzerland), vol. 23, no. 3, 2018.
Štulíková K, Karabín M, Nešpor J, et al. Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops. Molecules. 2018;23(3).
Štulíková, K., Karabín, M., Nešpor, J., & Dostálek, P. (2018). Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops. Molecules (Basel, Switzerland), 23(3). https://doi.org/10.3390/molecules23030660
Štulíková K, et al. Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen From Hops. Molecules. 2018 Mar 15;23(3) PubMed PMID: 29543713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops. AU - Štulíková,Kateřina, AU - Karabín,Marcel, AU - Nešpor,Jakub, AU - Dostálek,Pavel, Y1 - 2018/03/15/ PY - 2018/02/23/received PY - 2018/03/11/revised PY - 2018/03/14/accepted PY - 2018/3/16/entrez PY - 2018/3/16/pubmed PY - 2018/8/29/medline KW - 8-prenylnaringenin KW - hops KW - menopause KW - phytoestrogens JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 3 N2 - Hop (Humulus lupulus L.), as a key ingredient for beer brewing, is also a source of many biologically active molecules. A notable compound, 8-prenylnaringenin (8-PN), structurally belonging to the group of prenylated flavonoids, was shown to be a potent phytoestrogen, and thus, became the topic of active research. Here, we overview the pharmacological properties of 8-PN and its therapeutic opportunities. Due to its estrogenic effects, administration of 8-PN represents a novel therapeutic approach to the treatment of menopausal and post-menopausal symptoms that occur as a consequence of a progressive decline in hormone levels in women. Application of 8-PN in the treatment of menopause has been clinically examined with promising results. Other activities that have already been assessed include the potential to prevent bone-resorption or inhibition of tumor growth. On the other hand, the use of phytoestrogens is frequently questioned regarding possible adverse effects associated with long-term consumption. In conclusion, we emphasize the implications of using 8-PN in future treatments of menopausal and post-menopausal symptoms, including the need for precise evidence and further investigations to define the safety risks related to its therapeutic use. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/29543713/Therapeutic_Perspectives_of_8_Prenylnaringenin_a_Potent_Phytoestrogen_from_Hops_ DB - PRIME DP - Unbound Medicine ER -