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Structural correlates of mild cognitive impairment: A clinicovolumetric study.
Neurol India 2018 Mar-Apr; 66(2):370-376NI

Abstract

Context:

Annually 10-12% of patients with mild cognitive impairment (MCI) are likely to progress to Alzheimer's Disease (AD). The morphometric profile in stable non-converters has not been adequately characterized.

Aims

To determine the structural differences between amnestic MCI and early AD using volumetric magnetic resonance imaging (MRI) and its correlation with neuropsychological test performances.

Settings and Design:

This was a hospital-based case-control study.

Materials and Methods:

Twenty-four patients classified as having "non-progressor" MCI, 13 as having an early AD, and 25 controls, and assessed using neuropsychological evaluation, and three-dimensional T1-weighted 1.5T magnetic resonance maging (MRI) were included in the study. We used both voxel-based morphometry and automated regional volumetry to assess the topographical patterns of volume loss.

Statistical Analysis Used

Post-hoc analysis of variance was done for comparison between means, and partial correlation analysis was done for correlating volumetric and cognitive measures.

Results:

Consistently, significant atrophy of the superior temporal gyrus, left hippocampus, and mesial frontoparietal regions were identified in patients with MCI in comparison to controls. Increased atrophy in the limbic regions, temporal neocortex, and precuneus was identified in patients with early AD in comparison to patients with MCI. While differences in retention and recall scores between the groups were independent of age and volumetric variables, significant correlations were observed between the learning and recall scores and the volume of hippocampus in patients with MCI as well as temporal neocortex in patients with AD. Atrophy of the superior temporal gyrus and mesial neocortical regions represents the structural correlate of amnestic MCI parallel to the development of hippocampal atrophy.

Conclusions:

Identification of the pattern of volumetric abnormalities in patients with amnestic MCI in addition to atrophy of the medial temporal lobes necessitates a close follow up to continuously assess these patients for their progression to early AD.

Authors+Show Affiliations

Cognition and Behavioural Neurology Section, Department of Neurology, Sree ChitraTirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.Department of Imaging Sciences and Interventional Radiology, Biostatistics Sree ChitraTirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.Cognition and Behavioural Neurology Section, Department of Neurology, Sree ChitraTirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.Cognition and Behavioural Neurology Section, Department of Neurology, Sree ChitraTirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.Biostatistics Sree ChitraTirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.Cognition and Behavioural Neurology Section, Department of Neurology, Sree ChitraTirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29547157

Citation

Sheelakumari, R, et al. "Structural Correlates of Mild Cognitive Impairment: a Clinicovolumetric Study." Neurology India, vol. 66, no. 2, 2018, pp. 370-376.
Sheelakumari R, Kesavadas C, Lekha VS, et al. Structural correlates of mild cognitive impairment: A clinicovolumetric study. Neurol India. 2018;66(2):370-376.
Sheelakumari, R., Kesavadas, C., Lekha, V. S., Justus, S., Sarma, P. S., & Menon, R. (2018). Structural correlates of mild cognitive impairment: A clinicovolumetric study. Neurology India, 66(2), pp. 370-376. doi:10.4103/0028-3886.227298.
Sheelakumari R, et al. Structural Correlates of Mild Cognitive Impairment: a Clinicovolumetric Study. Neurol India. 2018;66(2):370-376. PubMed PMID: 29547157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural correlates of mild cognitive impairment: A clinicovolumetric study. AU - Sheelakumari,R, AU - Kesavadas,C, AU - Lekha,V S, AU - Justus,Sunitha, AU - Sarma,P Sankara, AU - Menon,Ramshekhar, PY - 2018/3/17/entrez PY - 2018/3/17/pubmed PY - 2019/9/17/medline KW - Alzheimer's disease KW - amnestic mild cognitive impairment KW - automated regional volumetry KW - voxel-based morphometry SP - 370 EP - 376 JF - Neurology India JO - Neurol India VL - 66 IS - 2 N2 - Context:: Annually 10-12% of patients with mild cognitive impairment (MCI) are likely to progress to Alzheimer's Disease (AD). The morphometric profile in stable non-converters has not been adequately characterized. Aims: To determine the structural differences between amnestic MCI and early AD using volumetric magnetic resonance imaging (MRI) and its correlation with neuropsychological test performances. Settings and Design:: This was a hospital-based case-control study. Materials and Methods:: Twenty-four patients classified as having "non-progressor" MCI, 13 as having an early AD, and 25 controls, and assessed using neuropsychological evaluation, and three-dimensional T1-weighted 1.5T magnetic resonance maging (MRI) were included in the study. We used both voxel-based morphometry and automated regional volumetry to assess the topographical patterns of volume loss. Statistical Analysis Used: Post-hoc analysis of variance was done for comparison between means, and partial correlation analysis was done for correlating volumetric and cognitive measures. Results:: Consistently, significant atrophy of the superior temporal gyrus, left hippocampus, and mesial frontoparietal regions were identified in patients with MCI in comparison to controls. Increased atrophy in the limbic regions, temporal neocortex, and precuneus was identified in patients with early AD in comparison to patients with MCI. While differences in retention and recall scores between the groups were independent of age and volumetric variables, significant correlations were observed between the learning and recall scores and the volume of hippocampus in patients with MCI as well as temporal neocortex in patients with AD. Atrophy of the superior temporal gyrus and mesial neocortical regions represents the structural correlate of amnestic MCI parallel to the development of hippocampal atrophy. Conclusions:: Identification of the pattern of volumetric abnormalities in patients with amnestic MCI in addition to atrophy of the medial temporal lobes necessitates a close follow up to continuously assess these patients for their progression to early AD. SN - 0028-3886 UR - https://www.unboundmedicine.com/medline/citation/29547157/Structural_correlates_of_mild_cognitive_impairment:_A_clinicovolumetric_study_ DB - PRIME DP - Unbound Medicine ER -