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Optimized Camellia sinensis var. sinensis, Ilex paraguariensis, and Aspalathus linearis blend presents high antioxidant and antiproliferative activities in a beverage model.
Food Chem. 2018 Jul 15; 254:348-358.FC

Abstract

A statistical optimization study was conducted to obtain a tea containing fermented rooibos (Aspalathus linearis), white tea (Camellia sinensis var. sinensis), and roasted mate (Ilex paraguariensis). An optimal combination of these species was proposed. This optimized tea inhibited 64% the lipoperoxidation in vitro and presented a high phenolic content, especially kaempferol, (+)-catechin, (-)-epicatechin, rutin, (-)-epigallocatechin, and (-)-epicatechin-2-O-gallate. Indeed, the antioxidant effect was confirmed by decreasing 30% the reactive oxygen species generation in human hepatoma carcinoma cells (HepG2, 100 and 240 µg/mL). In the cell viability assay, the GI50 for human colorectal adenocarcinoma epithelial cells (Caco-2) was about 547 µg/mL and 481 µg/mL for HepG2. The pasteurization process (65 °C/30 min) did not affect the total phenolic content and antioxidant activity of the optimized tea formulation. The sensory test indicated an acceptability index of 78%, showing that the analytical approach adopted was feasible to develop a phenolic-rich beverage.

Authors+Show Affiliations

Food Science and Technology Graduate Program, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, 84030-900 Ponta Grossa, PR, Brazil.Department of Food Engineering, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, 84030-900 Ponta Grossa, PR, Brazil.Graduate Program of Food Science and Technology, Agroindustrial Science and Technology Department, Federal University of Pelotas, Pelotas, RS, Brazil.Graduate Program of Food Science and Technology, Agroindustrial Science and Technology Department, Federal University of Pelotas, Pelotas, RS, Brazil.Department of Food Science, Faculty of Food Engineering, State University of Campinas, Campinas, SP, Brazil.Department of Food Science, Faculty of Food Engineering, State University of Campinas, Campinas, SP, Brazil.Federal University of Alfenas, Faculty of Nutrition, Rua Gabriel Monteiro da Silva, 714, 37130-000 Alfenas, MG, Brazil.Federal University of Alfenas, Faculty of Nutrition, Rua Gabriel Monteiro da Silva, 714, 37130-000 Alfenas, MG, Brazil.Food Science and Technology Graduate Program, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, 84030-900 Ponta Grossa, PR, Brazil; Department of Food Engineering, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, 84030-900 Ponta Grossa, PR, Brazil. Electronic address: dgranato@uepg.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29548463

Citation

Santos, Jânio S., et al. "Optimized Camellia Sinensis Var. Sinensis, Ilex Paraguariensis, and Aspalathus Linearis Blend Presents High Antioxidant and Antiproliferative Activities in a Beverage Model." Food Chemistry, vol. 254, 2018, pp. 348-358.
Santos JS, Deolindo CTP, Hoffmann JF, et al. Optimized Camellia sinensis var. sinensis, Ilex paraguariensis, and Aspalathus linearis blend presents high antioxidant and antiproliferative activities in a beverage model. Food Chem. 2018;254:348-358.
Santos, J. S., Deolindo, C. T. P., Hoffmann, J. F., Chaves, F. C., do Prado-Silva, L., Sant'Ana, A. S., Azevedo, L., do Carmo, M. A. V., & Granato, D. (2018). Optimized Camellia sinensis var. sinensis, Ilex paraguariensis, and Aspalathus linearis blend presents high antioxidant and antiproliferative activities in a beverage model. Food Chemistry, 254, 348-358. https://doi.org/10.1016/j.foodchem.2018.02.021
Santos JS, et al. Optimized Camellia Sinensis Var. Sinensis, Ilex Paraguariensis, and Aspalathus Linearis Blend Presents High Antioxidant and Antiproliferative Activities in a Beverage Model. Food Chem. 2018 Jul 15;254:348-358. PubMed PMID: 29548463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimized Camellia sinensis var. sinensis, Ilex paraguariensis, and Aspalathus linearis blend presents high antioxidant and antiproliferative activities in a beverage model. AU - Santos,Jânio S, AU - Deolindo,Carolina T P, AU - Hoffmann,Jessica F, AU - Chaves,Fabio C, AU - do Prado-Silva,Leonardo, AU - Sant'Ana,Anderson S, AU - Azevedo,Luciana, AU - do Carmo,Mariana Araújo Vieira, AU - Granato,Daniel, Y1 - 2018/02/06/ PY - 2017/10/11/received PY - 2018/01/31/revised PY - 2018/02/05/accepted PY - 2018/3/18/entrez PY - 2018/3/20/pubmed PY - 2018/11/1/medline KW - Antimicrobials KW - Cell viability KW - Desirability function KW - IC(50) KW - Phenolic compounds KW - Reactive oxygen species KW - Response surface methodology SP - 348 EP - 358 JF - Food chemistry JO - Food Chem VL - 254 N2 - A statistical optimization study was conducted to obtain a tea containing fermented rooibos (Aspalathus linearis), white tea (Camellia sinensis var. sinensis), and roasted mate (Ilex paraguariensis). An optimal combination of these species was proposed. This optimized tea inhibited 64% the lipoperoxidation in vitro and presented a high phenolic content, especially kaempferol, (+)-catechin, (-)-epicatechin, rutin, (-)-epigallocatechin, and (-)-epicatechin-2-O-gallate. Indeed, the antioxidant effect was confirmed by decreasing 30% the reactive oxygen species generation in human hepatoma carcinoma cells (HepG2, 100 and 240 µg/mL). In the cell viability assay, the GI50 for human colorectal adenocarcinoma epithelial cells (Caco-2) was about 547 µg/mL and 481 µg/mL for HepG2. The pasteurization process (65 °C/30 min) did not affect the total phenolic content and antioxidant activity of the optimized tea formulation. The sensory test indicated an acceptability index of 78%, showing that the analytical approach adopted was feasible to develop a phenolic-rich beverage. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/29548463/Optimized_Camellia_sinensis_var__sinensis_Ilex_paraguariensis_and_Aspalathus_linearis_blend_presents_high_antioxidant_and_antiproliferative_activities_in_a_beverage_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0308-8146(18)30247-4 DB - PRIME DP - Unbound Medicine ER -