Tags

Type your tag names separated by a space and hit enter

D-Trp6-luteinizing hormone-releasing hormone inhibits sulpiride-induced hyperprolactinemia in normal men.
J Clin Endocrinol Metab. 1987 Aug; 65(2):368-9.JC

Abstract

The effect of a potent agonistic analog of LHRH, D-Trp6-LHRH, on hyperprolactinemia induced by sulpiride was studied in normal men. Six men received sulpiride (100 mg, twice daily, orally) for 44 days. D-Trp6-LHRH was given sc during the last 2 weeks of sulpiride administration; the dose was 500 micrograms on the first day and 100 micrograms daily for the subsequent 14 days. All men had high serum PRL levels before D-Trp6-LHRH administration (mean +/- SEM, 56 +/- 9 ng/mL), which decreased significantly after the first dose of the analog (45 +/- 5 ng/mL; P = 0.031) and also after 15 days of analog administration (41 +/- 6 ng/mL; P = 0.016). These data demonstrate that administration of LHRH agonist can inhibit the hyperprolactinemic effect of sulpiride, suggesting a direct action of the analog on the pituitary gland to modulate PRL secretion.

Links

Publisher Full Text

Authors

Rubio MA
No affiliation info available
Torres-Aleman I
No affiliation info available
Calle JR
No affiliation info available
Cabranes JA
No affiliation info available
Schally AV
No affiliation info available
Charro AL
No affiliation info available

MeSH

Follicle Stimulating HormoneGonadotropin-Releasing HormoneHumansHyperprolactinemiaLuteinizing HormoneMaleSulpirideTriptorelin Pamoate

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2954994

Citation

Rubio, M A., et al. "D-Trp6-luteinizing Hormone-releasing Hormone Inhibits Sulpiride-induced Hyperprolactinemia in Normal Men." The Journal of Clinical Endocrinology and Metabolism, vol. 65, no. 2, 1987, pp. 368-9.
Rubio MA, Torres-Aleman I, Calle JR, et al. D-Trp6-luteinizing hormone-releasing hormone inhibits sulpiride-induced hyperprolactinemia in normal men. J Clin Endocrinol Metab. 1987;65(2):368-9.
Rubio, M. A., Torres-Aleman, I., Calle, J. R., Cabranes, J. A., Schally, A. V., & Charro, A. L. (1987). D-Trp6-luteinizing hormone-releasing hormone inhibits sulpiride-induced hyperprolactinemia in normal men. The Journal of Clinical Endocrinology and Metabolism, 65(2), 368-9.
Rubio MA, et al. D-Trp6-luteinizing Hormone-releasing Hormone Inhibits Sulpiride-induced Hyperprolactinemia in Normal Men. J Clin Endocrinol Metab. 1987;65(2):368-9. PubMed PMID: 2954994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - D-Trp6-luteinizing hormone-releasing hormone inhibits sulpiride-induced hyperprolactinemia in normal men. AU - Rubio,M A, AU - Torres-Aleman,I, AU - Calle,J R, AU - Cabranes,J A, AU - Schally,A V, AU - Charro,A L, PY - 1987/8/1/pubmed PY - 1987/8/1/medline PY - 1987/8/1/entrez SP - 368 EP - 9 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 65 IS - 2 N2 - The effect of a potent agonistic analog of LHRH, D-Trp6-LHRH, on hyperprolactinemia induced by sulpiride was studied in normal men. Six men received sulpiride (100 mg, twice daily, orally) for 44 days. D-Trp6-LHRH was given sc during the last 2 weeks of sulpiride administration; the dose was 500 micrograms on the first day and 100 micrograms daily for the subsequent 14 days. All men had high serum PRL levels before D-Trp6-LHRH administration (mean +/- SEM, 56 +/- 9 ng/mL), which decreased significantly after the first dose of the analog (45 +/- 5 ng/mL; P = 0.031) and also after 15 days of analog administration (41 +/- 6 ng/mL; P = 0.016). These data demonstrate that administration of LHRH agonist can inhibit the hyperprolactinemic effect of sulpiride, suggesting a direct action of the analog on the pituitary gland to modulate PRL secretion. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2954994/D_Trp6_luteinizing_hormone_releasing_hormone_inhibits_sulpiride_induced_hyperprolactinemia_in_normal_men_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-65-2-368 DB - PRIME DP - Unbound Medicine ER -