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D-Trp6-luteinizing hormone-releasing hormone inhibits sulpiride-induced hyperprolactinemia in normal men.
J Clin Endocrinol Metab. 1987 Aug; 65(2):368-9.JC

Abstract

The effect of a potent agonistic analog of LHRH, D-Trp6-LHRH, on hyperprolactinemia induced by sulpiride was studied in normal men. Six men received sulpiride (100 mg, twice daily, orally) for 44 days. D-Trp6-LHRH was given sc during the last 2 weeks of sulpiride administration; the dose was 500 micrograms on the first day and 100 micrograms daily for the subsequent 14 days. All men had high serum PRL levels before D-Trp6-LHRH administration (mean +/- SEM, 56 +/- 9 ng/mL), which decreased significantly after the first dose of the analog (45 +/- 5 ng/mL; P = 0.031) and also after 15 days of analog administration (41 +/- 6 ng/mL; P = 0.016). These data demonstrate that administration of LHRH agonist can inhibit the hyperprolactinemic effect of sulpiride, suggesting a direct action of the analog on the pituitary gland to modulate PRL secretion.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

2954994

Citation

Rubio, M A., et al. "D-Trp6-luteinizing Hormone-releasing Hormone Inhibits Sulpiride-induced Hyperprolactinemia in Normal Men." The Journal of Clinical Endocrinology and Metabolism, vol. 65, no. 2, 1987, pp. 368-9.
Rubio MA, Torres-Aleman I, Calle JR, et al. D-Trp6-luteinizing hormone-releasing hormone inhibits sulpiride-induced hyperprolactinemia in normal men. J Clin Endocrinol Metab. 1987;65(2):368-9.
Rubio, M. A., Torres-Aleman, I., Calle, J. R., Cabranes, J. A., Schally, A. V., & Charro, A. L. (1987). D-Trp6-luteinizing hormone-releasing hormone inhibits sulpiride-induced hyperprolactinemia in normal men. The Journal of Clinical Endocrinology and Metabolism, 65(2), 368-9.
Rubio MA, et al. D-Trp6-luteinizing Hormone-releasing Hormone Inhibits Sulpiride-induced Hyperprolactinemia in Normal Men. J Clin Endocrinol Metab. 1987;65(2):368-9. PubMed PMID: 2954994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - D-Trp6-luteinizing hormone-releasing hormone inhibits sulpiride-induced hyperprolactinemia in normal men. AU - Rubio,M A, AU - Torres-Aleman,I, AU - Calle,J R, AU - Cabranes,J A, AU - Schally,A V, AU - Charro,A L, PY - 1987/8/1/pubmed PY - 1987/8/1/medline PY - 1987/8/1/entrez SP - 368 EP - 9 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 65 IS - 2 N2 - The effect of a potent agonistic analog of LHRH, D-Trp6-LHRH, on hyperprolactinemia induced by sulpiride was studied in normal men. Six men received sulpiride (100 mg, twice daily, orally) for 44 days. D-Trp6-LHRH was given sc during the last 2 weeks of sulpiride administration; the dose was 500 micrograms on the first day and 100 micrograms daily for the subsequent 14 days. All men had high serum PRL levels before D-Trp6-LHRH administration (mean +/- SEM, 56 +/- 9 ng/mL), which decreased significantly after the first dose of the analog (45 +/- 5 ng/mL; P = 0.031) and also after 15 days of analog administration (41 +/- 6 ng/mL; P = 0.016). These data demonstrate that administration of LHRH agonist can inhibit the hyperprolactinemic effect of sulpiride, suggesting a direct action of the analog on the pituitary gland to modulate PRL secretion. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2954994/D_Trp6_luteinizing_hormone_releasing_hormone_inhibits_sulpiride_induced_hyperprolactinemia_in_normal_men_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-65-2-368 DB - PRIME DP - Unbound Medicine ER -