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Gastric parietal cell and thyroid autoantibodies in patients with Behcet's disease.
J Formos Med Assoc. 2018 Jun; 117(6):505-511.JF

Abstract

BACKGROUND/PURPOSE

Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) were rarely examined in Behcet's disease (BD) patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients.

METHODS

The frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients, 19 major-typed recurrent aphthous stomatitis (RAS)/BD (major RAS/BD) patients, 44 minor-typed RAS/BD (minor RAS/BD) patients, 520 RAS patients, and 126 healthy control subjects were calculated and compared.

RESULTS

We found that 14.3%, 20.6%, and 20.6% of 63 BD patients, 21.1%, 21.1%, and 26.3% of 19 major RAS/BD patients, 11.4%, 20.5%, and 18.2% of 44 minor RAS/BD patients, 11.5%, 18.5%, and 18.3% of 520 RAS patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subjects had serum GPCA, TGA, and TMA positivities, respectively. BD, major RAS/BD, minor RAS/BD, and RAS patients all had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.05). However, there were no significant differences in different serum autoantibody frequencies between BD, major RAS/BD, or minor RAS/BD patients and RAS patients. Of 16 TGA/TMA-positive BD patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 87.5%, 6.3%, and 6.3% of these TGA/TMA-positive BD patients had normal, lower, and higher serum TSH levels, respectively.

CONCLUSION

Approximately 35% BD patients have serum GPCA/TGA/TMA positivity. However, BD patients do not have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than RAS patients.

Authors+Show Affiliations

Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan; Department of Stomatology, MacKay Memorial Hospital, Taipei, Taiwan; School of Dentistry, Taipei Medical University, Taipei, Taiwan; School of Dentistry and Graduate Institute of Dental Sciences, China Medical University, Taichung, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29549982

Citation

Lin, Hung-Pin, et al. "Gastric Parietal Cell and Thyroid Autoantibodies in Patients With Behcet's Disease." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 117, no. 6, 2018, pp. 505-511.
Lin HP, Wu YH, Yu-Fong Chang J, et al. Gastric parietal cell and thyroid autoantibodies in patients with Behcet's disease. J Formos Med Assoc. 2018;117(6):505-511.
Lin, H. P., Wu, Y. H., Yu-Fong Chang, J., Wang, Y. P., Chen, H. M., & Sun, A. (2018). Gastric parietal cell and thyroid autoantibodies in patients with Behcet's disease. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 117(6), 505-511. https://doi.org/10.1016/j.jfma.2018.03.002
Lin HP, et al. Gastric Parietal Cell and Thyroid Autoantibodies in Patients With Behcet's Disease. J Formos Med Assoc. 2018;117(6):505-511. PubMed PMID: 29549982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric parietal cell and thyroid autoantibodies in patients with Behcet's disease. AU - Lin,Hung-Pin, AU - Wu,Yu-Hsueh, AU - Yu-Fong Chang,Julia, AU - Wang,Yi-Ping, AU - Chen,Hsin-Ming, AU - Sun,Andy, Y1 - 2018/03/15/ PY - 2018/01/31/received PY - 2018/02/21/revised PY - 2018/03/01/accepted PY - 2018/3/20/pubmed PY - 2018/10/17/medline PY - 2018/3/19/entrez KW - Autoantibody KW - Behcet's disease KW - Gastric parietal cell antibody KW - Recurrent aphthous stomatitis KW - Thyroglobulin antibody KW - Thyroid microsomal antibody SP - 505 EP - 511 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 117 IS - 6 N2 - BACKGROUND/PURPOSE: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) were rarely examined in Behcet's disease (BD) patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients. METHODS: The frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients, 19 major-typed recurrent aphthous stomatitis (RAS)/BD (major RAS/BD) patients, 44 minor-typed RAS/BD (minor RAS/BD) patients, 520 RAS patients, and 126 healthy control subjects were calculated and compared. RESULTS: We found that 14.3%, 20.6%, and 20.6% of 63 BD patients, 21.1%, 21.1%, and 26.3% of 19 major RAS/BD patients, 11.4%, 20.5%, and 18.2% of 44 minor RAS/BD patients, 11.5%, 18.5%, and 18.3% of 520 RAS patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subjects had serum GPCA, TGA, and TMA positivities, respectively. BD, major RAS/BD, minor RAS/BD, and RAS patients all had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.05). However, there were no significant differences in different serum autoantibody frequencies between BD, major RAS/BD, or minor RAS/BD patients and RAS patients. Of 16 TGA/TMA-positive BD patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 87.5%, 6.3%, and 6.3% of these TGA/TMA-positive BD patients had normal, lower, and higher serum TSH levels, respectively. CONCLUSION: Approximately 35% BD patients have serum GPCA/TGA/TMA positivity. However, BD patients do not have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than RAS patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/29549982/Gastric_parietal_cell_and_thyroid_autoantibodies_in_patients_with_Behcet's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(18)30067-6 DB - PRIME DP - Unbound Medicine ER -