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[Uric acid as electronic acceptor of chicken liver's XDH (author's transl)].
Rev Esp Fisiol. 1975 Dec; 31(4):255-63.RE

Abstract

Uric acid seems to act as an electronic acceptor in the dehydrogenation of hypoxanthine catalyzed by chicken liver's xanthinedehydrogenase (XDH). Oxidation was observed in crude homogenates under anaerobic conditions, although dialyzed homogenates or purified hepatic XDH also induce a similar action either in aerobic or anaerobic conditions. The reaction pH optimum is about 6.0. Xanthine appears to be the only inhibited product of the reaction when its concentration is greater than 1 X 10(-4) M. When hypoxanthine and uric acid concentrations exceed 2 X 10(-3) M and 1 X 10(-4) M, respectively, they induce inhibition by substrate. Purine is a fairly good substrate of XDH when uric acid acts as acceptor. Allopurinol inhibits hypoxanthine oxidation by uric acid in the presence of XDH. XDH also catalyzes the dismutation of xanthine to hypoxanthine and uric acid.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

2955

Citation

López-Solanas, V, and J Bozal. "[Uric Acid as Electronic Acceptor of Chicken Liver's XDH (author's Transl)]." Revista Espanola De Fisiologia, vol. 31, no. 4, 1975, pp. 255-63.
López-Solanas V, Bozal J. [Uric acid as electronic acceptor of chicken liver's XDH (author's transl)]. Rev Esp Fisiol. 1975;31(4):255-63.
López-Solanas, V., & Bozal, J. (1975). [Uric acid as electronic acceptor of chicken liver's XDH (author's transl)]. Revista Espanola De Fisiologia, 31(4), 255-63.
López-Solanas V, Bozal J. [Uric Acid as Electronic Acceptor of Chicken Liver's XDH (author's Transl)]. Rev Esp Fisiol. 1975;31(4):255-63. PubMed PMID: 2955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Uric acid as electronic acceptor of chicken liver's XDH (author's transl)]. AU - López-Solanas,V, AU - Bozal,J, PY - 1975/12/1/pubmed PY - 1975/12/1/medline PY - 1975/12/1/entrez SP - 255 EP - 63 JF - Revista espanola de fisiologia JO - Rev Esp Fisiol VL - 31 IS - 4 N2 - Uric acid seems to act as an electronic acceptor in the dehydrogenation of hypoxanthine catalyzed by chicken liver's xanthinedehydrogenase (XDH). Oxidation was observed in crude homogenates under anaerobic conditions, although dialyzed homogenates or purified hepatic XDH also induce a similar action either in aerobic or anaerobic conditions. The reaction pH optimum is about 6.0. Xanthine appears to be the only inhibited product of the reaction when its concentration is greater than 1 X 10(-4) M. When hypoxanthine and uric acid concentrations exceed 2 X 10(-3) M and 1 X 10(-4) M, respectively, they induce inhibition by substrate. Purine is a fairly good substrate of XDH when uric acid acts as acceptor. Allopurinol inhibits hypoxanthine oxidation by uric acid in the presence of XDH. XDH also catalyzes the dismutation of xanthine to hypoxanthine and uric acid. SN - 0034-9402 UR - https://www.unboundmedicine.com/medline/citation/2955/[Uric_acid_as_electronic_acceptor_of_chicken_liver's_XDH__author's_transl_]_ DB - PRIME DP - Unbound Medicine ER -