Tags

Type your tag names separated by a space and hit enter

Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders.
Complement Med Res. 2018; 25(3):173-182.CM

Abstract

BACKGROUND/AIMS

Validation of treatments with individually prescribed homeopathic medicines is a challenging task. A prognostic homeopathic patient questionnaire containing 140 keynote symptoms (highly characteristic of a specific homeopathic medicine) and an electronic algorithm to process the answers were used in 2 clinical studies. The algorithm outcome, based on total symptom scores, indicated 1 of 11 pre-selected homeopathic medicines for women with premenstrual syndrome and premenstrual dysphoric disorder (PMS/PMDD). Aims were (1) to estimate the prognostic values of keynote symptoms and (2) to evaluate the reliability of the homeopathic medicine ranking in the algorithm outcome.

METHODS

The prevalence of specific keynote symptoms was calculated in 145 women diagnosed with PMS/PMDD and in 40 included women with favorable outcomes using 1 of the 11 homeopathic medicines. Likelihood ratios (LRs) of the keynote symptoms were calculated. Pearson's correlations were calculated between 2 sets of total algorithm scores for 11 homeopathic medicines, obtained at 2 time points.

RESULTS

(1) A positive prognostic value (LR ≥ 1.5) was found in 34 keynote symptoms with a prevalence of 10-40%, with 10 symptoms already being connected to the corresponding homeopathic medicine in the algorithm. For example, the symptom 'common cold of the nose before menstruation' indicated Magnesium carbonicum with LR = 7.47 (confidence interval (CI) 3.90-14.28). (2) Pearson's correlations for the reliability evaluation varied from 0.69 to 0.84.

CONCLUSIONS

Recommendations can be made to improve the PMS algorithm with more accurate keynote symptoms. The prognostic questionnaire proved a reliable tool to rank 11 homeopathic medicines by total scores, based on keynote symptoms. This PMS algorithm can be used for the treatment of PMS/PMDD in clinical practice.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29550829

Citation

Klein-Laansma, Christien T., et al. "Evaluation of a Prognostic Homeopathic Questionnaire for Women With Premenstrual Disorders." Complementary Medicine Research, vol. 25, no. 3, 2018, pp. 173-182.
Klein-Laansma CT, Rutten ALB, Jansen JPCH, et al. Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders. Complement Med Res. 2018;25(3):173-182.
Klein-Laansma, C. T., Rutten, A. L. B., Jansen, J. P. C. H., van Wietmarschen, H., & Jong, M. C. (2018). Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders. Complementary Medicine Research, 25(3), 173-182. https://doi.org/10.1159/000487318
Klein-Laansma CT, et al. Evaluation of a Prognostic Homeopathic Questionnaire for Women With Premenstrual Disorders. Complement Med Res. 2018;25(3):173-182. PubMed PMID: 29550829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders. AU - Klein-Laansma,Christien T, AU - Rutten,Alexander L B, AU - Jansen,Jean Pierre C H, AU - van Wietmarschen,Herman, AU - Jong,Miek C, Y1 - 2018/03/19/ PY - 2018/3/20/pubmed PY - 2019/9/19/medline PY - 2018/3/19/entrez KW - Homeopathy KW - Likelihood ratio KW - PMS/PMDD KW - Premenstrual KW - Prognostic factor KW - Questionnaire KW - Reliability SP - 173 EP - 182 JF - Complementary medicine research JO - Complement Med Res VL - 25 IS - 3 N2 - BACKGROUND/AIMS: Validation of treatments with individually prescribed homeopathic medicines is a challenging task. A prognostic homeopathic patient questionnaire containing 140 keynote symptoms (highly characteristic of a specific homeopathic medicine) and an electronic algorithm to process the answers were used in 2 clinical studies. The algorithm outcome, based on total symptom scores, indicated 1 of 11 pre-selected homeopathic medicines for women with premenstrual syndrome and premenstrual dysphoric disorder (PMS/PMDD). Aims were (1) to estimate the prognostic values of keynote symptoms and (2) to evaluate the reliability of the homeopathic medicine ranking in the algorithm outcome. METHODS: The prevalence of specific keynote symptoms was calculated in 145 women diagnosed with PMS/PMDD and in 40 included women with favorable outcomes using 1 of the 11 homeopathic medicines. Likelihood ratios (LRs) of the keynote symptoms were calculated. Pearson's correlations were calculated between 2 sets of total algorithm scores for 11 homeopathic medicines, obtained at 2 time points. RESULTS: (1) A positive prognostic value (LR ≥ 1.5) was found in 34 keynote symptoms with a prevalence of 10-40%, with 10 symptoms already being connected to the corresponding homeopathic medicine in the algorithm. For example, the symptom 'common cold of the nose before menstruation' indicated Magnesium carbonicum with LR = 7.47 (confidence interval (CI) 3.90-14.28). (2) Pearson's correlations for the reliability evaluation varied from 0.69 to 0.84. CONCLUSIONS: Recommendations can be made to improve the PMS algorithm with more accurate keynote symptoms. The prognostic questionnaire proved a reliable tool to rank 11 homeopathic medicines by total scores, based on keynote symptoms. This PMS algorithm can be used for the treatment of PMS/PMDD in clinical practice. SN - 2504-2106 UR - https://www.unboundmedicine.com/medline/citation/29550829/Evaluation_of_a_Prognostic_Homeopathic_Questionnaire_for_Women_with_Premenstrual_Disorders_ L2 - https://www.karger.com?DOI=10.1159/000487318 DB - PRIME DP - Unbound Medicine ER -