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Causes of hyperhomocysteinemia and its pathological significance.
Arch Pharm Res. 2018 Apr; 41(4):372-383.AP

Abstract

In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia is a state in which too much homocysteine is present in the body. The main cause of hyperhomocysteinemia is a dysfunction of enzymes and cofactors associated with the process of homocysteine biosynthesis. Other causes include excessive methionine intake, certain diseases and side effects of some drugs. Hyperhomocysteinemia is a trigger for many diseases, such as atherosclerosis, congestive heart failure, age-related macular degeneration, Alzheimer's disease and hearing loss. There are many studies showing a positive relationship between homocysteine level and various symptoms. We speculate that a high level of homocysteine can be the sole reason or an aggravating factor in numerous diseases for which causal links are not fully understood.

Authors+Show Affiliations

Ewha Institute for Global Pharmacy Leadership, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Republic of Korea.Ewha Institute for Global Pharmacy Leadership, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Republic of Korea.Ewha Institute for Global Pharmacy Leadership, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Republic of Korea.Ewha Institute for Global Pharmacy Leadership, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Republic of Korea. ykwon@ewha.ac.kr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29552692

Citation

Kim, Jihyun, et al. "Causes of Hyperhomocysteinemia and Its Pathological Significance." Archives of Pharmacal Research, vol. 41, no. 4, 2018, pp. 372-383.
Kim J, Kim H, Roh H, et al. Causes of hyperhomocysteinemia and its pathological significance. Arch Pharm Res. 2018;41(4):372-383.
Kim, J., Kim, H., Roh, H., & Kwon, Y. (2018). Causes of hyperhomocysteinemia and its pathological significance. Archives of Pharmacal Research, 41(4), 372-383. https://doi.org/10.1007/s12272-018-1016-4
Kim J, et al. Causes of Hyperhomocysteinemia and Its Pathological Significance. Arch Pharm Res. 2018;41(4):372-383. PubMed PMID: 29552692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Causes of hyperhomocysteinemia and its pathological significance. AU - Kim,Jihyun, AU - Kim,Hyunhee, AU - Roh,Heewon, AU - Kwon,Youngjoo, Y1 - 2018/03/19/ PY - 2017/05/23/received PY - 2018/02/26/accepted PY - 2018/3/20/pubmed PY - 2018/9/25/medline PY - 2018/3/20/entrez KW - Disease caused by hyperhomocysteinemia KW - Homocysteine KW - Hyperhomocysteinemia SP - 372 EP - 383 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 41 IS - 4 N2 - In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia is a state in which too much homocysteine is present in the body. The main cause of hyperhomocysteinemia is a dysfunction of enzymes and cofactors associated with the process of homocysteine biosynthesis. Other causes include excessive methionine intake, certain diseases and side effects of some drugs. Hyperhomocysteinemia is a trigger for many diseases, such as atherosclerosis, congestive heart failure, age-related macular degeneration, Alzheimer's disease and hearing loss. There are many studies showing a positive relationship between homocysteine level and various symptoms. We speculate that a high level of homocysteine can be the sole reason or an aggravating factor in numerous diseases for which causal links are not fully understood. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/29552692/Causes_of_hyperhomocysteinemia_and_its_pathological_significance_ L2 - https://dx.doi.org/10.1007/s12272-018-1016-4 DB - PRIME DP - Unbound Medicine ER -