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Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis.
J Histochem Cytochem. 2018 07; 66(7):511-522.JH

Abstract

Amplification of fibroblast growth factor receptor 1 (FGFR1) has been reported in many squamous cell carcinomas, and human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma has been characterized as a distinct subset with favorable prognosis. Here, we investigated the FGFR1 amplification and HPV status in tonsillar squamous cell carcinoma (TSCC) and analyzed the clinical characteristics. HPV in situ hybridization (HPV ISH) and FGFR1 fluorescence in situ hybridization (FISH) were performed using tissue microarray from 89 cases of TSCC. Fourteen of 89 (15.7%) TSCC cases had FGFR1 amplification, and HPV was detected in 59 of 89 (66.3%) cases. FGFR1 amplification status was not associated with HPV positivity (p=0.765). Outcomes were not significantly different between FGFR1 amplified and non-amplified patients. Although FGFR1 amplified patients (n=4) in the HPV ISH-negative group (n=30) had a tendency for poorer overall survival, no statistical significance was identified (p=0.150, log-rank). FGFR1 protein overexpression showed better disease-free survival (p=0.031, log-rank) in HPV-negative TSCC. This study suggests FGFR1 amplification may be important in the pathogenesis of TSCC regardless of HPV status.

Authors+Show Affiliations

Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.Department of Pathology, Veterans Health Service Medical Center, Seoul, Republic of Korea.Departments of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.Medical Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.Departments of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29553868

Citation

Park, Soonchan, et al. "Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis." The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society, vol. 66, no. 7, 2018, pp. 511-522.
Park S, Lee M, Cho KJ, et al. Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. J Histochem Cytochem. 2018;66(7):511-522.
Park, S., Lee, M., Cho, K. J., Kim, S. B., Roh, J. L., Choi, S. H., Nam, S. Y., Kim, S. Y., & Song, J. S. (2018). Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society, 66(7), 511-522. https://doi.org/10.1369/0022155418761652
Park S, et al. Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. J Histochem Cytochem. 2018;66(7):511-522. PubMed PMID: 29553868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis. AU - Park,Soonchan, AU - Lee,Miji, AU - Cho,Kyung-Ja, AU - Kim,Sung Bae, AU - Roh,Jong-Lyel, AU - Choi,Seung-Ho, AU - Nam,Soon Yuhl, AU - Kim,Sang Yoon, AU - Song,Joon Seon, Y1 - 2018/03/19/ PY - 2018/3/20/pubmed PY - 2019/8/1/medline PY - 2018/3/20/entrez KW - fibroblast growth factor receptor 1 KW - fluorescence in situ hybridization KW - human papillomavirus KW - squamous cell carcinoma KW - tonsil SP - 511 EP - 522 JF - The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society JO - J. Histochem. Cytochem. VL - 66 IS - 7 N2 - Amplification of fibroblast growth factor receptor 1 (FGFR1) has been reported in many squamous cell carcinomas, and human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma has been characterized as a distinct subset with favorable prognosis. Here, we investigated the FGFR1 amplification and HPV status in tonsillar squamous cell carcinoma (TSCC) and analyzed the clinical characteristics. HPV in situ hybridization (HPV ISH) and FGFR1 fluorescence in situ hybridization (FISH) were performed using tissue microarray from 89 cases of TSCC. Fourteen of 89 (15.7%) TSCC cases had FGFR1 amplification, and HPV was detected in 59 of 89 (66.3%) cases. FGFR1 amplification status was not associated with HPV positivity (p=0.765). Outcomes were not significantly different between FGFR1 amplified and non-amplified patients. Although FGFR1 amplified patients (n=4) in the HPV ISH-negative group (n=30) had a tendency for poorer overall survival, no statistical significance was identified (p=0.150, log-rank). FGFR1 protein overexpression showed better disease-free survival (p=0.031, log-rank) in HPV-negative TSCC. This study suggests FGFR1 amplification may be important in the pathogenesis of TSCC regardless of HPV status. SN - 1551-5044 UR - https://www.unboundmedicine.com/medline/citation/29553868/Association_Between_Fibroblast_Growth_Factor_Receptor_1_Gene_Amplification_and_Human_Papillomavirus_Prevalence_in_Tonsillar_Squamous_Cell_Carcinoma_With_Clinicopathologic_Analysis_ L2 - http://journals.sagepub.com/doi/full/10.1369/0022155418761652?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -