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Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: A focus on human studies.

Abstract

Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors and the onset and consolidation of dementia and Alzheimer's disease (AD). It has been demonstrated that AD, diabetes, obesity, insulin resistance, and cardiovascular disease are strongly interconnected pathologies. Preventive strategies and nutritional interventions seem to be promising approaches to delay neurocognitive decline and reduce the risk of AD and other non-psychiatric co-morbidities. In this regard, healthy dietary patterns, characterized by high intake of plant-based foods, probiotics, antioxidants, soy beans, nuts, and omega-3 polyunsaturated fatty acids, and a low intake of saturated fats, animal-derived proteins, and refined sugars, have been shown to decrease the risk of neurocognitive impairments and eventually the onset of AD. Here we review the role of some nutrients and, in particular, of healthy dietary patterns, such as the Mediterranean diet and other emerging healthy diets, DASH (Dietary Approach to Stop Hypertension) and MIND (Mediterranean-DASH dietIntervention for Neurodegenerative Delay), for the maintenance of cognitive performance, focusing specifically on human studies. The beneficial effects associated with overall diet composition, rather than single nutrient supplementations, for the prevention or the delay of AD and dementia are discussed.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Centre for Nutrition and Health, Universidad Europea del Atlántico (UEA), Santander, Spain.

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    Centre for Nutrition and Health, Universidad Europea del Atlántico (UEA), Santander, Spain.

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    Centre for Nutrition and Health, Universidad Europea del Atlántico (UEA), Santander, Spain.

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    Centre for Nutrition and Health, Universidad Europea del Atlántico (UEA), Santander, Spain.

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    Centre for Nutrition and Health, Universidad Europea del Atlántico (UEA), Santander, Spain.

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    Universidad Internacional Iberoamericana (UNINI), Campeche, Mexico.

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    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy.

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    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy. Electronic address: f.giampieri@univpm.it.

    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy. Electronic address: m.a.battino@univpm.it.

    Source

    Pharmacological research 131: 2018 05 pg 32-43

    MeSH

    Alzheimer Disease
    Dementia
    Diet Therapy
    Diet, Mediterranean
    Dietary Supplements
    Healthy Diet
    Humans
    Hypertension
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    29555333

    Citation

    Pistollato, Francesca, et al. "Nutritional Patterns Associated With the Maintenance of Neurocognitive Functions and the Risk of Dementia and Alzheimer's Disease: a Focus On Human Studies." Pharmacological Research, vol. 131, 2018, pp. 32-43.
    Pistollato F, Iglesias RC, Ruiz R, et al. Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: A focus on human studies. Pharmacol Res. 2018;131:32-43.
    Pistollato, F., Iglesias, R. C., Ruiz, R., Aparicio, S., Crespo, J., Lopez, L. D., ... Battino, M. (2018). Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: A focus on human studies. Pharmacological Research, 131, pp. 32-43. doi:10.1016/j.phrs.2018.03.012.
    Pistollato F, et al. Nutritional Patterns Associated With the Maintenance of Neurocognitive Functions and the Risk of Dementia and Alzheimer's Disease: a Focus On Human Studies. Pharmacol Res. 2018;131:32-43. PubMed PMID: 29555333.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: A focus on human studies. AU - Pistollato,Francesca, AU - Iglesias,Ruben Calderón, AU - Ruiz,Roberto, AU - Aparicio,Silvia, AU - Crespo,Jorge, AU - Lopez,Luis Dzul, AU - Manna,Piera Pia, AU - Giampieri,Francesca, AU - Battino,Maurizio, Y1 - 2018/03/16/ PY - 2017/12/15/received PY - 2018/03/15/revised PY - 2018/03/15/accepted PY - 2018/3/21/pubmed PY - 2019/2/1/medline PY - 2018/3/21/entrez KW - Alzheimer’s disease KW - Cognitive functions KW - DASH diet KW - Dementia KW - MIND diet KW - Mediterranean diet KW - Nutrient supplementations SP - 32 EP - 43 JF - Pharmacological research JO - Pharmacol. Res. VL - 131 N2 - Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors and the onset and consolidation of dementia and Alzheimer's disease (AD). It has been demonstrated that AD, diabetes, obesity, insulin resistance, and cardiovascular disease are strongly interconnected pathologies. Preventive strategies and nutritional interventions seem to be promising approaches to delay neurocognitive decline and reduce the risk of AD and other non-psychiatric co-morbidities. In this regard, healthy dietary patterns, characterized by high intake of plant-based foods, probiotics, antioxidants, soy beans, nuts, and omega-3 polyunsaturated fatty acids, and a low intake of saturated fats, animal-derived proteins, and refined sugars, have been shown to decrease the risk of neurocognitive impairments and eventually the onset of AD. Here we review the role of some nutrients and, in particular, of healthy dietary patterns, such as the Mediterranean diet and other emerging healthy diets, DASH (Dietary Approach to Stop Hypertension) and MIND (Mediterranean-DASH dietIntervention for Neurodegenerative Delay), for the maintenance of cognitive performance, focusing specifically on human studies. The beneficial effects associated with overall diet composition, rather than single nutrient supplementations, for the prevention or the delay of AD and dementia are discussed. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/29555333/Nutritional_patterns_associated_with_the_maintenance_of_neurocognitive_functions_and_the_risk_of_dementia_and_Alzheimer's_disease:_A_focus_on_human_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(17)31630-4 DB - PRIME DP - Unbound Medicine ER -