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The centennial lesson of encephalitis lethargica.
Neurology. 2018 03 20; 90(12):563-567.Neur

Abstract

We commemorate the centenary of Constantin von Economo's description of encephalitis lethargica, a mysterious disease that had a significant effect on 20th-century neuroscience. In the acute phase, encephalitis lethargica was marked by intractable somnolence, which von Economo attributed to lesions in the diencephalon, thereby paving the way for future efforts to localize the regulation of sleep in the subcortical brain. At the same time, neuropathologic findings in postencephalitic parkinsonism affirmed the role of the substantia nigra in the pathophysiology of parkinsonism. The occurrence of psychiatric symptoms in patients with encephalitis lethargica-such as mood disorders, obsessive-compulsive behavior, and bradyphrenia-drew attention to the organic basis of mental illness.

Authors+Show Affiliations

From the Faculty of Medicine (B.L.), University Medical Center Utrecht, the Netherlands; Neuroscience Historian (P.F.), Sydney, Australia; and Department of Neurology (P.J.K.), Zuyderland Medical Center, Heerlen, the Netherlands.From the Faculty of Medicine (B.L.), University Medical Center Utrecht, the Netherlands; Neuroscience Historian (P.F.), Sydney, Australia; and Department of Neurology (P.J.K.), Zuyderland Medical Center, Heerlen, the Netherlands.From the Faculty of Medicine (B.L.), University Medical Center Utrecht, the Netherlands; Neuroscience Historian (P.F.), Sydney, Australia; and Department of Neurology (P.J.K.), Zuyderland Medical Center, Heerlen, the Netherlands. pkoehler@neurohistory.nl.

Pub Type(s)

Biography
Historical Article
Journal Article

Language

eng

PubMed ID

29555881

Citation

Lutters, Bart, et al. "The Centennial Lesson of Encephalitis Lethargica." Neurology, vol. 90, no. 12, 2018, pp. 563-567.
Lutters B, Foley P, Koehler PJ. The centennial lesson of encephalitis lethargica. Neurology. 2018;90(12):563-567.
Lutters, B., Foley, P., & Koehler, P. J. (2018). The centennial lesson of encephalitis lethargica. Neurology, 90(12), 563-567. https://doi.org/10.1212/WNL.0000000000005176
Lutters B, Foley P, Koehler PJ. The Centennial Lesson of Encephalitis Lethargica. Neurology. 2018 03 20;90(12):563-567. PubMed PMID: 29555881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The centennial lesson of encephalitis lethargica. AU - Lutters,Bart, AU - Foley,Paul, AU - Koehler,Peter J, PY - 2017/08/12/received PY - 2017/12/08/accepted PY - 2018/3/21/entrez PY - 2018/3/21/pubmed PY - 2019/7/31/medline SP - 563 EP - 567 JF - Neurology JO - Neurology VL - 90 IS - 12 N2 - We commemorate the centenary of Constantin von Economo's description of encephalitis lethargica, a mysterious disease that had a significant effect on 20th-century neuroscience. In the acute phase, encephalitis lethargica was marked by intractable somnolence, which von Economo attributed to lesions in the diencephalon, thereby paving the way for future efforts to localize the regulation of sleep in the subcortical brain. At the same time, neuropathologic findings in postencephalitic parkinsonism affirmed the role of the substantia nigra in the pathophysiology of parkinsonism. The occurrence of psychiatric symptoms in patients with encephalitis lethargica-such as mood disorders, obsessive-compulsive behavior, and bradyphrenia-drew attention to the organic basis of mental illness. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/29555881/The_centennial_lesson_of_encephalitis_lethargica_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=29555881 DB - PRIME DP - Unbound Medicine ER -