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Age at menarche and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.
Endocrine 2018; 61(2):204-209E

Abstract

PURPOSE

Epidemiological studies had demonstrated that early age at menarche increased the risk of type 2 diabetes (T2DM), and gestational diabetes mellitus (GDM) shares many risk factors and features with T2DM. Thus, age at menarche may be a potential factor in the development of GDM. The aim of this study was to assess the association between age at menarche and the risk of gestational diabetes mellitus.

METHODS

The databases of PubMed, Embase, Web of Science and Cochrane Library were searched up to June 2017.

RESULTS

A total of 50,535 participants from five individual studies were included in the meta-analyses to evaluate the risk of GDM. Meta-analysis showed that women with menarche at an early age (≤11 years) had a higher GDM risk than those with menarche at age ≥12 years. (OR = 1.45, 95% CI = 1.26-1.68; P < .00001) There was low heterogeneity among the studies (Q = 6.4; P = 0.17; I2 = 38).

CONCLUSIONS

This meta-analysis demonstrated that earlier menarche was strongly associated with an increased risk of GDM. A history of early age at menarche may help identify women at high risk of GDM and allow the implementation for the strategy of early prevention.

Authors+Show Affiliations

Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China.Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China.Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China.Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China.Wenzhou Medical University, 325000, Wenzhou, People's Republic of China.Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China.Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China. chuangchi@163.com.Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China. liangshanmu@hotmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

29556913

Citation

Sun, Xiaoting, et al. "Age at Menarche and the Risk of Gestational Diabetes Mellitus: a Systematic Review and Meta-analysis." Endocrine, vol. 61, no. 2, 2018, pp. 204-209.
Sun X, Yang L, Pan J, et al. Age at menarche and the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Endocrine. 2018;61(2):204-209.
Sun, X., Yang, L., Pan, J., Yang, H., Wu, Y., Chen, Z., ... Mu, L. (2018). Age at menarche and the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Endocrine, 61(2), pp. 204-209. doi:10.1007/s12020-018-1581-9.
Sun X, et al. Age at Menarche and the Risk of Gestational Diabetes Mellitus: a Systematic Review and Meta-analysis. Endocrine. 2018;61(2):204-209. PubMed PMID: 29556913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age at menarche and the risk of gestational diabetes mellitus: a systematic review and meta-analysis. AU - Sun,Xiaoting, AU - Yang,Lili, AU - Pan,Jiexue, AU - Yang,Haiyan, AU - Wu,Yanting, AU - Chen,Zimiao, AU - Chen,Xia, AU - Mu,Liangshan, Y1 - 2018/03/20/ PY - 2017/10/23/received PY - 2018/03/09/accepted PY - 2018/3/21/pubmed PY - 2019/1/29/medline PY - 2018/3/21/entrez KW - Age at menarche KW - Gestational diabetes mellitus KW - Menarche SP - 204 EP - 209 JF - Endocrine JO - Endocrine VL - 61 IS - 2 N2 - PURPOSE: Epidemiological studies had demonstrated that early age at menarche increased the risk of type 2 diabetes (T2DM), and gestational diabetes mellitus (GDM) shares many risk factors and features with T2DM. Thus, age at menarche may be a potential factor in the development of GDM. The aim of this study was to assess the association between age at menarche and the risk of gestational diabetes mellitus. METHODS: The databases of PubMed, Embase, Web of Science and Cochrane Library were searched up to June 2017. RESULTS: A total of 50,535 participants from five individual studies were included in the meta-analyses to evaluate the risk of GDM. Meta-analysis showed that women with menarche at an early age (≤11 years) had a higher GDM risk than those with menarche at age ≥12 years. (OR = 1.45, 95% CI = 1.26-1.68; P < .00001) There was low heterogeneity among the studies (Q = 6.4; P = 0.17; I2 = 38). CONCLUSIONS: This meta-analysis demonstrated that earlier menarche was strongly associated with an increased risk of GDM. A history of early age at menarche may help identify women at high risk of GDM and allow the implementation for the strategy of early prevention. SN - 1559-0100 UR - https://www.unboundmedicine.com/medline/citation/29556913/Age_at_menarche_and_the_risk_of_gestational_diabetes_mellitus:_a_systematic_review_and_meta_analysis_ L2 - https://dx.doi.org/10.1007/s12020-018-1581-9 DB - PRIME DP - Unbound Medicine ER -