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Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition.
Eur J Clin Nutr. 2018 05; 72(5):657-664.EJ

Abstract

Collateral fattening refers to the process whereby excess fat is deposited as a result of the body's attempt to counter a deficit in lean mass through overeating. Its demonstration and significance to weight regulation and obesity can be traced to work on energy budget strategies in growing mammals and birds, and to men recovering from experimental starvation. The cardinal features of collateral fattening rests upon (i) the existence of a feedback system between lean tissue and appetite control, with lean tissue deficit driving hyperphagia, and (ii) upon the occurrence of a temporal desynchronization in the recovery of body composition, with complete recovery of fat mass preceeding that of lean mass. Under these conditions, persistent hyperphagia driven by the need to complete the recovery of lean tissue will result in the excess fat deposition (hence collateral fattening) and fat overshooting. After reviewing the main lines of evidence for the phenomenon of collateral fattening in body composition autoregulation, this article discusses the causes and determinants of the desynchronization in fat and lean tissue recovery leading to collateral fattening and fat overshooting, and points to their significance in the mechanisms by which dieting, developmental programming and sedentariness predispose to obesity.

Authors+Show Affiliations

Department of Endocrinology, Metabolism and Cardiovascular System, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. abdul.dulloo@unifr.ch.Department of Endocrinology, Metabolism and Cardiovascular System, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.Department of Endocrinology, Metabolism and Cardiovascular System, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29559726

Citation

Dulloo, Abdul G., et al. "Collateral Fattening in Body Composition Autoregulation: Its Determinants and Significance for Obesity Predisposition." European Journal of Clinical Nutrition, vol. 72, no. 5, 2018, pp. 657-664.
Dulloo AG, Miles-Chan JL, Schutz Y. Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition. Eur J Clin Nutr. 2018;72(5):657-664.
Dulloo, A. G., Miles-Chan, J. L., & Schutz, Y. (2018). Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition. European Journal of Clinical Nutrition, 72(5), 657-664. https://doi.org/10.1038/s41430-018-0138-6
Dulloo AG, Miles-Chan JL, Schutz Y. Collateral Fattening in Body Composition Autoregulation: Its Determinants and Significance for Obesity Predisposition. Eur J Clin Nutr. 2018;72(5):657-664. PubMed PMID: 29559726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition. AU - Dulloo,Abdul G, AU - Miles-Chan,Jennifer L, AU - Schutz,Yves, Y1 - 2018/03/20/ PY - 2018/02/07/received PY - 2018/02/10/accepted PY - 2018/3/22/pubmed PY - 2019/5/6/medline PY - 2018/3/22/entrez SP - 657 EP - 664 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 72 IS - 5 N2 - Collateral fattening refers to the process whereby excess fat is deposited as a result of the body's attempt to counter a deficit in lean mass through overeating. Its demonstration and significance to weight regulation and obesity can be traced to work on energy budget strategies in growing mammals and birds, and to men recovering from experimental starvation. The cardinal features of collateral fattening rests upon (i) the existence of a feedback system between lean tissue and appetite control, with lean tissue deficit driving hyperphagia, and (ii) upon the occurrence of a temporal desynchronization in the recovery of body composition, with complete recovery of fat mass preceeding that of lean mass. Under these conditions, persistent hyperphagia driven by the need to complete the recovery of lean tissue will result in the excess fat deposition (hence collateral fattening) and fat overshooting. After reviewing the main lines of evidence for the phenomenon of collateral fattening in body composition autoregulation, this article discusses the causes and determinants of the desynchronization in fat and lean tissue recovery leading to collateral fattening and fat overshooting, and points to their significance in the mechanisms by which dieting, developmental programming and sedentariness predispose to obesity. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/29559726/Collateral_fattening_in_body_composition_autoregulation:_its_determinants_and_significance_for_obesity_predisposition_ DB - PRIME DP - Unbound Medicine ER -