TY - JOUR
T1 - Effect of a combination of ethinylestradiol and desogestrel in adolescents with oligomenorrhea and ovarian hyperandrogenism.
AU - Nappi,C,
AU - Farace,M J,
AU - Leone,F,
AU - Minutolo,M,
AU - Tommaselli,A P,
AU - Montemagno,U,
PY - 1987/7/1/pubmed
PY - 1987/7/1/medline
PY - 1987/7/1/entrez
KW - Acne--prevention and control
KW - Adolescents
KW - Adolescents, Female
KW - Age Factors
KW - Androgens
KW - Biology
KW - Comparative Studies
KW - Contraception
KW - Contraceptive Agents, Estrogen--pharmacodynamics
KW - Contraceptive Agents, Female--pharmacodynamics
KW - Contraceptive Agents, Progestin--pharmacodynamics
KW - Contraceptive Agents--pharmacodynamics
KW - Contraceptive Methods
KW - Demographic Factors
KW - Dermatitis
KW - Diseases
KW - Endocrine System
KW - Ethinyl Estradiol--pharmacodynamics
KW - Family Planning
KW - Genitalia
KW - Genitalia, Female
KW - Gonadotropins
KW - Gonadotropins, Pituitary
KW - Hirsutism--prevention and control
KW - Hormones
KW - Luteinizing Hormone
KW - Menstruation Disorders
KW - Norgestrel--pharmacodynamics
KW - Oral Contraceptives
KW - Oral Contraceptives, Combined
KW - Ovarian Effects
KW - Ovary
KW - Physiology
KW - Population
KW - Population Characteristics
KW - Research Methodology
KW - Signs And Symptoms
KW - Studies
KW - Testosterone
KW - Treatment
KW - Urogenital System
KW - Youth
SP - 209
EP - 19
JF - European journal of obstetrics, gynecology, and reproductive biology
JO - Eur J Obstet Gynecol Reprod Biol
VL - 25
IS - 3
N2 - Nine oligomenorrheic adolescent girls with a clinical and hormonal picture of ovarian hyperandrogenism were treated with a monophasic oral contraceptive (OC) containing 0.03 mg ethinylestradiol (EE) plus 0.150 mg desogestrel (DOG) for six months. The same treatment was administered in eight eumenorrheic adolescents. In both groups the treatment induced a decrease in LH, FSH, androstenedione (delta 4-A), testosterone (T) and dehydroepiandrosterone sulphate (DHEA-S) levels associated with a significant sex-hormone-binding globulin (SHBG) increase. In oligomenorrheic adolescents a marked decrease in both the total ovarian volume and the number of cystic follicles was observed. All parameters, except SHBG and ovarian volume in hyperandrogenic girls, returned to pre-treatment values 3 months after treatment. Subjective improvement of skin problems occurred in six of the nine oligomenorrheic girls. Although temporary, the EE + DOG formulation pill is effective in the treatment of ovarian hyperandrogenism in adolescents. It may also be useful for the prevention of the progressive transformation in the 'classical' and 'irreversible' micropolycystic ovary of adult age.
SN - 0301-2115
UR - https://www.unboundmedicine.com/medline/citation/2956138/Effect_of_a_combination_of_ethinylestradiol_and_desogestrel_in_adolescents_with_oligomenorrhea_and_ovarian_hyperandrogenism_
L2 - https://linkinghub.elsevier.com/retrieve/pii/0028-2243(87)90101-8
DB - PRIME
DP - Unbound Medicine
ER -