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Effect of a combination of ethinylestradiol and desogestrel in adolescents with oligomenorrhea and ovarian hyperandrogenism.
Eur J Obstet Gynecol Reprod Biol. 1987 Jul; 25(3):209-19.EJ

Abstract

Nine oligomenorrheic adolescent girls with a clinical and hormonal picture of ovarian hyperandrogenism were treated with a monophasic oral contraceptive (OC) containing 0.03 mg ethinylestradiol (EE) plus 0.150 mg desogestrel (DOG) for six months. The same treatment was administered in eight eumenorrheic adolescents. In both groups the treatment induced a decrease in LH, FSH, androstenedione (delta 4-A), testosterone (T) and dehydroepiandrosterone sulphate (DHEA-S) levels associated with a significant sex-hormone-binding globulin (SHBG) increase. In oligomenorrheic adolescents a marked decrease in both the total ovarian volume and the number of cystic follicles was observed. All parameters, except SHBG and ovarian volume in hyperandrogenic girls, returned to pre-treatment values 3 months after treatment. Subjective improvement of skin problems occurred in six of the nine oligomenorrheic girls. Although temporary, the EE + DOG formulation pill is effective in the treatment of ovarian hyperandrogenism in adolescents. It may also be useful for the prevention of the progressive transformation in the 'classical' and 'irreversible' micropolycystic ovary of adult age.

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Publisher Full Text

Authors

Nappi C
No affiliation info available
Farace MJ
No affiliation info available
Leone F
No affiliation info available
Minutolo M
No affiliation info available
Tommaselli AP
No affiliation info available
Montemagno U
No affiliation info available

MeSH

AdolescentAndrogensContraceptives, Oral, CombinedDesogestrelEthinyl EstradiolFemaleGonadal Steroid HormonesHumansMenstrual CycleMenstruation DisturbancesNorpregnenesOligomenorrheaPolycystic Ovary Syndrome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2956138

Citation

Nappi, C, et al. "Effect of a Combination of Ethinylestradiol and Desogestrel in Adolescents With Oligomenorrhea and Ovarian Hyperandrogenism." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 25, no. 3, 1987, pp. 209-19.
Nappi C, Farace MJ, Leone F, et al. Effect of a combination of ethinylestradiol and desogestrel in adolescents with oligomenorrhea and ovarian hyperandrogenism. Eur J Obstet Gynecol Reprod Biol. 1987;25(3):209-19.
Nappi, C., Farace, M. J., Leone, F., Minutolo, M., Tommaselli, A. P., & Montemagno, U. (1987). Effect of a combination of ethinylestradiol and desogestrel in adolescents with oligomenorrhea and ovarian hyperandrogenism. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 25(3), 209-19.
Nappi C, et al. Effect of a Combination of Ethinylestradiol and Desogestrel in Adolescents With Oligomenorrhea and Ovarian Hyperandrogenism. Eur J Obstet Gynecol Reprod Biol. 1987;25(3):209-19. PubMed PMID: 2956138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a combination of ethinylestradiol and desogestrel in adolescents with oligomenorrhea and ovarian hyperandrogenism. AU - Nappi,C, AU - Farace,M J, AU - Leone,F, AU - Minutolo,M, AU - Tommaselli,A P, AU - Montemagno,U, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez KW - Acne--prevention and control KW - Adolescents KW - Adolescents, Female KW - Age Factors KW - Androgens KW - Biology KW - Comparative Studies KW - Contraception KW - Contraceptive Agents, Estrogen--pharmacodynamics KW - Contraceptive Agents, Female--pharmacodynamics KW - Contraceptive Agents, Progestin--pharmacodynamics KW - Contraceptive Agents--pharmacodynamics KW - Contraceptive Methods KW - Demographic Factors KW - Dermatitis KW - Diseases KW - Endocrine System KW - Ethinyl Estradiol--pharmacodynamics KW - Family Planning KW - Genitalia KW - Genitalia, Female KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hirsutism--prevention and control KW - Hormones KW - Luteinizing Hormone KW - Menstruation Disorders KW - Norgestrel--pharmacodynamics KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Ovarian Effects KW - Ovary KW - Physiology KW - Population KW - Population Characteristics KW - Research Methodology KW - Signs And Symptoms KW - Studies KW - Testosterone KW - Treatment KW - Urogenital System KW - Youth SP - 209 EP - 19 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 25 IS - 3 N2 - Nine oligomenorrheic adolescent girls with a clinical and hormonal picture of ovarian hyperandrogenism were treated with a monophasic oral contraceptive (OC) containing 0.03 mg ethinylestradiol (EE) plus 0.150 mg desogestrel (DOG) for six months. The same treatment was administered in eight eumenorrheic adolescents. In both groups the treatment induced a decrease in LH, FSH, androstenedione (delta 4-A), testosterone (T) and dehydroepiandrosterone sulphate (DHEA-S) levels associated with a significant sex-hormone-binding globulin (SHBG) increase. In oligomenorrheic adolescents a marked decrease in both the total ovarian volume and the number of cystic follicles was observed. All parameters, except SHBG and ovarian volume in hyperandrogenic girls, returned to pre-treatment values 3 months after treatment. Subjective improvement of skin problems occurred in six of the nine oligomenorrheic girls. Although temporary, the EE + DOG formulation pill is effective in the treatment of ovarian hyperandrogenism in adolescents. It may also be useful for the prevention of the progressive transformation in the 'classical' and 'irreversible' micropolycystic ovary of adult age. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/2956138/Effect_of_a_combination_of_ethinylestradiol_and_desogestrel_in_adolescents_with_oligomenorrhea_and_ovarian_hyperandrogenism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0028-2243(87)90101-8 DB - PRIME DP - Unbound Medicine ER -