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Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study.
Neurosci Bull. 2018 Jun; 34(3):497-506.NB

Abstract

Attention deficit hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamine D4 receptor (DRD4) on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity (ReHo) and functional connectivity (FC). Resting-state functional magnetic resonance imaging data were analyzed in 49 children with ADHD. All participants were classified as either carriers of the DRD4 4-repeat/4-repeat (4R/4R) allele (n = 30) or the DRD4 2-repeat (2R) allele (n = 19). The results showed that participants with the DRD4 2R allele had decreased ReHo bilaterally in the posterior lobes of the cerebellum, while ReHo was increased in the left angular gyrus. Compared with participants carrying the DRD4 4R/4R allele, those with the DRD4 2R allele showed decreased FC to the left angular gyrus in the left striatum, right inferior frontal gyrus, and bilateral lobes of the cerebellum. The increased FC regions included the left superior frontal gyrus, medial frontal gyrus, and rectus gyrus. These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop. Our study not only enhances the understanding of the correlation between the cerebellar lobes and ADHD, but also provides an imaging basis for explaining the neural mechanisms underlying ADHD in children.

Authors+Show Affiliations

Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.Department of Radiology, Yancheng First People's Hospital, Yancheng, 224000, China.Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.Department of Mental Health, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.Department of Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.Department of Psychiatry, Wenzhou Medical University, Wenzhou, 325000, China. cocozk1986@163.com.Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. wzwangmh@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29564731

Citation

Qian, Andan, et al. "Dopamine D4 Receptor Gene Associated With the Frontal-Striatal-Cerebellar Loop in Children With ADHD: a Resting-State fMRI Study." Neuroscience Bulletin, vol. 34, no. 3, 2018, pp. 497-506.
Qian A, Wang X, Liu H, et al. Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study. Neurosci Bull. 2018;34(3):497-506.
Qian, A., Wang, X., Liu, H., Tao, J., Zhou, J., Ye, Q., Li, J., Yang, C., Cheng, J., Zhao, K., & Wang, M. (2018). Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study. Neuroscience Bulletin, 34(3), 497-506. https://doi.org/10.1007/s12264-018-0217-7
Qian A, et al. Dopamine D4 Receptor Gene Associated With the Frontal-Striatal-Cerebellar Loop in Children With ADHD: a Resting-State fMRI Study. Neurosci Bull. 2018;34(3):497-506. PubMed PMID: 29564731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine D4 Receptor Gene Associated with the Frontal-Striatal-Cerebellar Loop in Children with ADHD: A Resting-State fMRI Study. AU - Qian,Andan, AU - Wang,Xin, AU - Liu,Huiru, AU - Tao,Jiejie, AU - Zhou,Jiejie, AU - Ye,Qiong, AU - Li,Jiance, AU - Yang,Chuang, AU - Cheng,Jingliang, AU - Zhao,Ke, AU - Wang,Meihao, Y1 - 2018/03/21/ PY - 2017/08/28/received PY - 2018/01/10/accepted PY - 2018/3/23/pubmed PY - 2018/9/19/medline PY - 2018/3/23/entrez KW - Attention deficit hyperactivity disorder KW - Dopamine D4 receptor KW - Frontal-striatal-cerebellar loop KW - Functional connectivity KW - Regional homogeneity KW - Resting-state functional magnetic resonance imaging SP - 497 EP - 506 JF - Neuroscience bulletin JO - Neurosci Bull VL - 34 IS - 3 N2 - Attention deficit hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder that has been linked to the dopaminergic system. This study aimed to investigate the effects of regulation of the dopamine D4 receptor (DRD4) on functional brain activity during the resting state in ADHD children using the methods of regional homogeneity (ReHo) and functional connectivity (FC). Resting-state functional magnetic resonance imaging data were analyzed in 49 children with ADHD. All participants were classified as either carriers of the DRD4 4-repeat/4-repeat (4R/4R) allele (n = 30) or the DRD4 2-repeat (2R) allele (n = 19). The results showed that participants with the DRD4 2R allele had decreased ReHo bilaterally in the posterior lobes of the cerebellum, while ReHo was increased in the left angular gyrus. Compared with participants carrying the DRD4 4R/4R allele, those with the DRD4 2R allele showed decreased FC to the left angular gyrus in the left striatum, right inferior frontal gyrus, and bilateral lobes of the cerebellum. The increased FC regions included the left superior frontal gyrus, medial frontal gyrus, and rectus gyrus. These data suggest that the DRD4 polymorphisms are associated with localized brain activity and specific functional connections, including abnormality in the frontal-striatal-cerebellar loop. Our study not only enhances the understanding of the correlation between the cerebellar lobes and ADHD, but also provides an imaging basis for explaining the neural mechanisms underlying ADHD in children. SN - 1995-8218 UR - https://www.unboundmedicine.com/medline/citation/29564731/Dopamine_D4_Receptor_Gene_Associated_with_the_Frontal_Striatal_Cerebellar_Loop_in_Children_with_ADHD:_A_Resting_State_fMRI_Study_ L2 - https://dx.doi.org/10.1007/s12264-018-0217-7 DB - PRIME DP - Unbound Medicine ER -