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Transcranial magnetic motor evoked potentials and magnetic resonance imaging findings in paraplegic dogs with recovery of motor function.
J Vet Intern Med. 2018 May; 32(3):1116-1125.JV

Abstract

BACKGROUND

Transcranial magnetic motor evoked potentials (TMMEP) are associated with severity of clinical signs and magnetic resonance imaging (MRI) findings in dogs with spinal cord disease.

HYPOTHESIS

That in initially paraplegic dogs with thoracolumbar intervertebral disc herniation (IVDH), MRI findings before surgery and TMMEPs obtained after decompressive surgery are associated with long-term neurological status and correlate with each other.

ANIMALS

Seventeen client-owned paraplegic dogs with acute thoracolumbar IVDH.

METHODS

Prospective observational study. TMMEPs were obtained from pelvic limbs and MRI (3T) of the spinal cord was performed at initial clinical presentation. Follow-up studies were performed ≤ 2 days after reappearance of motor function and 3 months later. Ratios of compression length, intramedullary hyperintensities' length (T2-weighted hyperintensity length ratio [T2WLR]), and lesion extension (T2-weighted-lesion extension ratio) in relation to the length of the 2nd lumbar vertebral body were calculated.

RESULTS

TMMEPs could be elicited in 10/17 (59%) dogs at 1st and in 16/17 (94%) dogs at 2nd follow-up. Comparison of TMMEPs of 1st and 2nd follow-up showed significantly increased amplitudes (median from 0.19 to 0.45 mV) and decreased latencies (from 69.38 to 40.26 ms; P = .01 and .001, respectively). At 2nd follow-up latencies were significantly associated with ambulatory status (P = .024). T2WLR obtained before surgery correlated with latencies at 2nd follow-up (P = .04).

CONCLUSIONS

TMMEP reflect motor function recovery after severe spinal cord injury.

Authors+Show Affiliations

Division of Neurology, Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.Division of Neurology, Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany. Institute of Biometry, Epidemiology, and Information Processing, University of Veterinary Medicine Hannover, Hannover, Germany.Division of Neurology, Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.Institute of Biometry, Epidemiology, and Information Processing, University of Veterinary Medicine Hannover, Hannover, Germany.Division of Neurology, Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany. Centre of Systems Neuroscience, Hannover, Germany.Division of Neurology, Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29566440

Citation

Siedenburg, Johannes S., et al. "Transcranial Magnetic Motor Evoked Potentials and Magnetic Resonance Imaging Findings in Paraplegic Dogs With Recovery of Motor Function." Journal of Veterinary Internal Medicine, vol. 32, no. 3, 2018, pp. 1116-1125.
Siedenburg JS, Wang-Leandro A, Amendt HL, et al. Transcranial magnetic motor evoked potentials and magnetic resonance imaging findings in paraplegic dogs with recovery of motor function. J Vet Intern Med. 2018;32(3):1116-1125.
Siedenburg, J. S., Wang-Leandro, A., Amendt, H. L., Rohn, K., Tipold, A., & Stein, V. M. (2018). Transcranial magnetic motor evoked potentials and magnetic resonance imaging findings in paraplegic dogs with recovery of motor function. Journal of Veterinary Internal Medicine, 32(3), 1116-1125. https://doi.org/10.1111/jvim.15058
Siedenburg JS, et al. Transcranial Magnetic Motor Evoked Potentials and Magnetic Resonance Imaging Findings in Paraplegic Dogs With Recovery of Motor Function. J Vet Intern Med. 2018;32(3):1116-1125. PubMed PMID: 29566440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcranial magnetic motor evoked potentials and magnetic resonance imaging findings in paraplegic dogs with recovery of motor function. AU - Siedenburg,Johannes S, AU - Wang-Leandro,Adriano, AU - Amendt,Hanna-Luise, AU - Rohn,Karl, AU - Tipold,Andrea, AU - Stein,Veronika M, Y1 - 2018/03/22/ PY - 2017/02/19/received PY - 2017/10/27/revised PY - 2018/01/11/accepted PY - 2018/3/23/pubmed PY - 2018/10/3/medline PY - 2018/3/23/entrez KW - canine KW - magnetic resonance imaging KW - spinal cord injury KW - therapy monitoring KW - transcranial magnetic stimulation SP - 1116 EP - 1125 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 32 IS - 3 N2 - BACKGROUND: Transcranial magnetic motor evoked potentials (TMMEP) are associated with severity of clinical signs and magnetic resonance imaging (MRI) findings in dogs with spinal cord disease. HYPOTHESIS: That in initially paraplegic dogs with thoracolumbar intervertebral disc herniation (IVDH), MRI findings before surgery and TMMEPs obtained after decompressive surgery are associated with long-term neurological status and correlate with each other. ANIMALS: Seventeen client-owned paraplegic dogs with acute thoracolumbar IVDH. METHODS: Prospective observational study. TMMEPs were obtained from pelvic limbs and MRI (3T) of the spinal cord was performed at initial clinical presentation. Follow-up studies were performed ≤ 2 days after reappearance of motor function and 3 months later. Ratios of compression length, intramedullary hyperintensities' length (T2-weighted hyperintensity length ratio [T2WLR]), and lesion extension (T2-weighted-lesion extension ratio) in relation to the length of the 2nd lumbar vertebral body were calculated. RESULTS: TMMEPs could be elicited in 10/17 (59%) dogs at 1st and in 16/17 (94%) dogs at 2nd follow-up. Comparison of TMMEPs of 1st and 2nd follow-up showed significantly increased amplitudes (median from 0.19 to 0.45 mV) and decreased latencies (from 69.38 to 40.26 ms; P = .01 and .001, respectively). At 2nd follow-up latencies were significantly associated with ambulatory status (P = .024). T2WLR obtained before surgery correlated with latencies at 2nd follow-up (P = .04). CONCLUSIONS: TMMEP reflect motor function recovery after severe spinal cord injury. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/29566440/Transcranial_magnetic_motor_evoked_potentials_and_magnetic_resonance_imaging_findings_in_paraplegic_dogs_with_recovery_of_motor_function_ L2 - https://doi.org/10.1111/jvim.15058 DB - PRIME DP - Unbound Medicine ER -