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Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin.
Life Sci 2018; 201:17-29LS

Abstract

Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive loss of lung function due to tissue scarring. A variety of pro-inflammatory and pro-fibrogenic factors including interleukin‑17A, transforming growth factor β, Wnt/β‑catenin, vascular endothelial growth factor, platelet-derived growth factor, fibroblast growth factors, endotelin‑1, renin angiotensin system and impaired caveolin‑1 function are involved in the IPF pathogenesis. Current therapies for IPF have some limitations and this highlights the need for effective therapeutic agents to treat this fatal disease. Melatonin and its metabolites are broad-spectrum antioxidants that not only remove reactive oxygen and nitrogen species by radical scavenging but also up-regulate the expression and activity of endogenous antioxidants. Via these actions, melatonin and its metabolites modulate a variety of molecular pathways in different pathophysiological conditions. Herein, we review the signaling pathways involved in the pathophysiology of IPF and the potentially protective effects of melatonin on these pathways.

Authors+Show Affiliations

Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.Air Pollution Research Center, Iran University of Medical Sciences, Tehran, Iran.Department of Cellular and Structural Biology, UT Health, San Antonio, TX, USA.Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran; Department of Anesthesiology, Ilam University of Medical Sciences, Ilam, Iran.Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: mehrzadi.s@iums.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29567077

Citation

Hosseinzadeh, Azam, et al. "Idiopathic Pulmonary Fibrosis (IPF) Signaling Pathways and Protective Roles of Melatonin." Life Sciences, vol. 201, 2018, pp. 17-29.
Hosseinzadeh A, Javad-Moosavi SA, Reiter RJ, et al. Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin. Life Sci. 2018;201:17-29.
Hosseinzadeh, A., Javad-Moosavi, S. A., Reiter, R. J., Hemati, K., Ghaznavi, H., & Mehrzadi, S. (2018). Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin. Life Sciences, 201, pp. 17-29. doi:10.1016/j.lfs.2018.03.032.
Hosseinzadeh A, et al. Idiopathic Pulmonary Fibrosis (IPF) Signaling Pathways and Protective Roles of Melatonin. Life Sci. 2018 May 15;201:17-29. PubMed PMID: 29567077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin. AU - Hosseinzadeh,Azam, AU - Javad-Moosavi,Seyed Ali, AU - Reiter,Russel J, AU - Hemati,Karim, AU - Ghaznavi,Habib, AU - Mehrzadi,Saeed, Y1 - 2018/03/19/ PY - 2017/12/21/received PY - 2018/03/13/revised PY - 2018/03/15/accepted PY - 2018/3/24/pubmed PY - 2018/5/24/medline PY - 2018/3/24/entrez KW - Angiotensin II KW - Caveolin‑1 KW - Endothelin‑1 KW - Growth factor KW - Inflammation KW - Melatonin KW - Pulmonary fibrosis KW - Wnt/β‑catenin SP - 17 EP - 29 JF - Life sciences JO - Life Sci. VL - 201 N2 - Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive loss of lung function due to tissue scarring. A variety of pro-inflammatory and pro-fibrogenic factors including interleukin‑17A, transforming growth factor β, Wnt/β‑catenin, vascular endothelial growth factor, platelet-derived growth factor, fibroblast growth factors, endotelin‑1, renin angiotensin system and impaired caveolin‑1 function are involved in the IPF pathogenesis. Current therapies for IPF have some limitations and this highlights the need for effective therapeutic agents to treat this fatal disease. Melatonin and its metabolites are broad-spectrum antioxidants that not only remove reactive oxygen and nitrogen species by radical scavenging but also up-regulate the expression and activity of endogenous antioxidants. Via these actions, melatonin and its metabolites modulate a variety of molecular pathways in different pathophysiological conditions. Herein, we review the signaling pathways involved in the pathophysiology of IPF and the potentially protective effects of melatonin on these pathways. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/29567077/Idiopathic_pulmonary_fibrosis__IPF__signaling_pathways_and_protective_roles_of_melatonin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(18)30138-3 DB - PRIME DP - Unbound Medicine ER -