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Ultrasensitive photoelectrochemical aptasensor for lead ion detection based on sensitization effect of CdTe QDs on MoS2-CdS:Mn nanocomposites by the formation of G-quadruplex structure.
Talanta. 2018 Jun 01; 183:237-244.T

Abstract

An ultrasensitive photoelectrochemical (PEC) aptasensor for lead ion (Pb2+) detection was fabricated based on MoS2-CdS:Mn nanocomposites and sensitization effect of CdTe quantum dots (QDs). MoS2-CdS:Mn modified electrode was used as the PEC matrix for the immobilization of probe DNA (pDNA) labeled with CdTe QDs. Target DNA (tDNA) were hybridized with pDNA to made the QDs locate away from the electrode surface by the rod-like double helix. The detection of Pb2+ was based on the conformational change of the pDNA to G-quadruplex structure in the presence of Pb2+, which made the labeled QDs move close to the electrode surface, leading to the generation of sensitization effect and evident increase of the photocurrent intensity. The linear range was 50 fM to 100 nM with a detection limit of 16.7 fM. The recoveries of the determination of Pb2+ in real samples were in the range of 102.5-108.0%. This proposed PEC aptasensor provides a new sensing strategy for various heavy metal ions at ultralow levels.

Authors+Show Affiliations

School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China. Electronic address: jjshi@aust.edu.cn.School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China.School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China.School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China.School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China.School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29567170

Citation

Shi, Jian-Jun, et al. "Ultrasensitive Photoelectrochemical Aptasensor for Lead Ion Detection Based On Sensitization Effect of CdTe QDs On MoS2-CdS:Mn Nanocomposites By the Formation of G-quadruplex Structure." Talanta, vol. 183, 2018, pp. 237-244.
Shi JJ, Zhu JC, Zhao M, et al. Ultrasensitive photoelectrochemical aptasensor for lead ion detection based on sensitization effect of CdTe QDs on MoS2-CdS:Mn nanocomposites by the formation of G-quadruplex structure. Talanta. 2018;183:237-244.
Shi, J. J., Zhu, J. C., Zhao, M., Wang, Y., Yang, P., & He, J. (2018). Ultrasensitive photoelectrochemical aptasensor for lead ion detection based on sensitization effect of CdTe QDs on MoS2-CdS:Mn nanocomposites by the formation of G-quadruplex structure. Talanta, 183, 237-244. https://doi.org/10.1016/j.talanta.2018.02.087
Shi JJ, et al. Ultrasensitive Photoelectrochemical Aptasensor for Lead Ion Detection Based On Sensitization Effect of CdTe QDs On MoS2-CdS:Mn Nanocomposites By the Formation of G-quadruplex Structure. Talanta. 2018 Jun 1;183:237-244. PubMed PMID: 29567170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrasensitive photoelectrochemical aptasensor for lead ion detection based on sensitization effect of CdTe QDs on MoS2-CdS:Mn nanocomposites by the formation of G-quadruplex structure. AU - Shi,Jian-Jun, AU - Zhu,Jing-Chun, AU - Zhao,Ming, AU - Wang,Yan, AU - Yang,Ping, AU - He,Jie, Y1 - 2018/03/19/ PY - 2017/07/30/received PY - 2018/01/13/revised PY - 2018/02/21/accepted PY - 2018/3/24/entrez PY - 2018/3/24/pubmed PY - 2018/9/4/medline KW - Aptasensor KW - Lead ion KW - Molybdenum disulfide KW - Photoelectrochemistry KW - Quantum dots KW - Sensitization effect SP - 237 EP - 244 JF - Talanta JO - Talanta VL - 183 N2 - An ultrasensitive photoelectrochemical (PEC) aptasensor for lead ion (Pb2+) detection was fabricated based on MoS2-CdS:Mn nanocomposites and sensitization effect of CdTe quantum dots (QDs). MoS2-CdS:Mn modified electrode was used as the PEC matrix for the immobilization of probe DNA (pDNA) labeled with CdTe QDs. Target DNA (tDNA) were hybridized with pDNA to made the QDs locate away from the electrode surface by the rod-like double helix. The detection of Pb2+ was based on the conformational change of the pDNA to G-quadruplex structure in the presence of Pb2+, which made the labeled QDs move close to the electrode surface, leading to the generation of sensitization effect and evident increase of the photocurrent intensity. The linear range was 50 fM to 100 nM with a detection limit of 16.7 fM. The recoveries of the determination of Pb2+ in real samples were in the range of 102.5-108.0%. This proposed PEC aptasensor provides a new sensing strategy for various heavy metal ions at ultralow levels. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/29567170/Ultrasensitive_photoelectrochemical_aptasensor_for_lead_ion_detection_based_on_sensitization_effect_of_CdTe_QDs_on_MoS2_CdS:Mn_nanocomposites_by_the_formation_of_G_quadruplex_structure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(18)30204-2 DB - PRIME DP - Unbound Medicine ER -