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A fast and simple air-assisted liquid-liquid microextraction procedure for the simultaneous determination of bisphenols, parabens, benzophenones, triclosan, and triclocarban in human urine by liquid chromatography-tandem mass spectrometry.
Talanta. 2018 Jun 01; 183:94-101.T

Abstract

The increasing awareness and public concern with hazard exposure to endocrine-disrupting chemicals calls for methods capable to handle numerous samples in short analysis time. In this present study, a novel method combining air-assisted liquid-liquid microextraction and liquid chromatography coupled to mass spectrometry was developed and validated for the extraction, preconcentration, and determination of 7 bisphenols (bisphenol A, bisphenol S, bisphenol AP, bisphenol P, bisphenol F, bisphenol AF, bisphenol Z), 7 parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-paraben, methyl-protocatechuic acid, and ethyl-protocatechuic acid), 5 benzophenones (benzophenone-1, benzophenone-2, benzophenone-3, benzophenone-8, and 4-hydroxybenzophenone), and two antimicrobials (triclosan and triclocarban) in human urine samples. Type and volume of solvent, extraction time (cycles), pH sample, ionic strength, agitation, and needle dimensions were evaluated. The matrix-matched calibration curves of all analytes were linear with correlation coefficients higher than 0.99 in the range level of 1.0-20.0 ng mL-1. The relative standard deviation, precision, at three concentrations (1.0, 10.0 and 20.0 ng mL-1) was lower than 15% with accuracy ranging from 90% to 114%. The biomonitoring capability of the new proposed method was confirmed with the analysis of 50 human urine samples randomly collected from Brazilian children. High urinary concentrations of several EDCs associated with usage of personal care products were found.

Authors+Show Affiliations

Laboratório de Toxicologia e Essencialidade de Metais, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14049-903 Ribeirão Preto, SP, Brazil.Departmento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14049-901 Ribeirão Preto, SP, Brazil.Laboratório de Toxicologia e Essencialidade de Metais, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14049-903 Ribeirão Preto, SP, Brazil. Electronic address: fbarbosa@fcfrp.usp.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29567194

Citation

Rocha, Bruno Alves, et al. "A Fast and Simple Air-assisted Liquid-liquid Microextraction Procedure for the Simultaneous Determination of Bisphenols, Parabens, Benzophenones, Triclosan, and Triclocarban in Human Urine By Liquid Chromatography-tandem Mass Spectrometry." Talanta, vol. 183, 2018, pp. 94-101.
Rocha BA, de Oliveira ARM, Barbosa F. A fast and simple air-assisted liquid-liquid microextraction procedure for the simultaneous determination of bisphenols, parabens, benzophenones, triclosan, and triclocarban in human urine by liquid chromatography-tandem mass spectrometry. Talanta. 2018;183:94-101.
Rocha, B. A., de Oliveira, A. R. M., & Barbosa, F. (2018). A fast and simple air-assisted liquid-liquid microextraction procedure for the simultaneous determination of bisphenols, parabens, benzophenones, triclosan, and triclocarban in human urine by liquid chromatography-tandem mass spectrometry. Talanta, 183, 94-101. https://doi.org/10.1016/j.talanta.2018.02.052
Rocha BA, de Oliveira ARM, Barbosa F. A Fast and Simple Air-assisted Liquid-liquid Microextraction Procedure for the Simultaneous Determination of Bisphenols, Parabens, Benzophenones, Triclosan, and Triclocarban in Human Urine By Liquid Chromatography-tandem Mass Spectrometry. Talanta. 2018 Jun 1;183:94-101. PubMed PMID: 29567194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A fast and simple air-assisted liquid-liquid microextraction procedure for the simultaneous determination of bisphenols, parabens, benzophenones, triclosan, and triclocarban in human urine by liquid chromatography-tandem mass spectrometry. AU - Rocha,Bruno Alves, AU - de Oliveira,Anderson Rodrigo Moraes, AU - Barbosa,Fernando,Jr Y1 - 2018/02/13/ PY - 2018/01/05/received PY - 2018/02/10/revised PY - 2018/02/12/accepted PY - 2018/3/24/entrez PY - 2018/3/24/pubmed PY - 2018/9/4/medline KW - Air-assisted liquid-liquid microextraction KW - Endocrine-disrupting chemicals KW - Fast procedure KW - Human Biomonitoring KW - Liquid chromatography-tandem mass spectrometry KW - Urine SP - 94 EP - 101 JF - Talanta JO - Talanta VL - 183 N2 - The increasing awareness and public concern with hazard exposure to endocrine-disrupting chemicals calls for methods capable to handle numerous samples in short analysis time. In this present study, a novel method combining air-assisted liquid-liquid microextraction and liquid chromatography coupled to mass spectrometry was developed and validated for the extraction, preconcentration, and determination of 7 bisphenols (bisphenol A, bisphenol S, bisphenol AP, bisphenol P, bisphenol F, bisphenol AF, bisphenol Z), 7 parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-paraben, methyl-protocatechuic acid, and ethyl-protocatechuic acid), 5 benzophenones (benzophenone-1, benzophenone-2, benzophenone-3, benzophenone-8, and 4-hydroxybenzophenone), and two antimicrobials (triclosan and triclocarban) in human urine samples. Type and volume of solvent, extraction time (cycles), pH sample, ionic strength, agitation, and needle dimensions were evaluated. The matrix-matched calibration curves of all analytes were linear with correlation coefficients higher than 0.99 in the range level of 1.0-20.0 ng mL-1. The relative standard deviation, precision, at three concentrations (1.0, 10.0 and 20.0 ng mL-1) was lower than 15% with accuracy ranging from 90% to 114%. The biomonitoring capability of the new proposed method was confirmed with the analysis of 50 human urine samples randomly collected from Brazilian children. High urinary concentrations of several EDCs associated with usage of personal care products were found. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/29567194/A_fast_and_simple_air_assisted_liquid_liquid_microextraction_procedure_for_the_simultaneous_determination_of_bisphenols_parabens_benzophenones_triclosan_and_triclocarban_in_human_urine_by_liquid_chromatography_tandem_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(18)30160-7 DB - PRIME DP - Unbound Medicine ER -