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Superiority of constructive interference in steady-state MRI sequencing over T1-weighted MRI sequencing for evaluating cavernous sinus invasion by pituitary macroadenomas.
J Neurosurg 2018; :1-8JN

Abstract

OBJECTIVE

Preoperatively determining the extent of parasellar invasion of pituitary macroadenomas is useful for surgical planning and patient counseling. Here, the authors compared constructive interference in steady state (CISS), a T2-weighted gradient-echo MRI sequence, to volume-interpolated breath-hold examination (VIBE), a T1-weighted gradient-echo MRI sequence, for evaluation of cavernous sinus invasion (CSI) by pituitary macroadenomas.

METHODS

VIBE and CISS images of 98 patients with pituitary macroadenoma were retrospectively analyzed and graded using the modified Knosp classification. The Knosp grades were correlated to surgical findings of CSI, which were determined intraoperatively using 0° and 30° endoscopes. The predictive accuracies for CSI according to the Knosp grades derived from the CISS and VIBE images were compared using receiver operating characteristic (ROC) curves. Postoperative MRI was used to evaluate the gross-total resection (GTR) rates.

RESULTS

The CSI rate by pituitary macroadenomas was 27.6% (27 of 98 cases). Of 196 assessments (left and right sides of 98 macroadenomas), 45 (23.0%) had different Knosp grades when scored using VIBE versus CISS images. For the VIBE images, 0% of Knosp grade 0, 4.5% of grade 1, 23.8% of grade 2, 42.1% of grade 3A, 100% of grade 3B, and 83.3% of grade 4 macroadenomas were found to have CSI intraoperatively. For the CISS images, 0% of Knosp grade 0, 2.1% of grade 1, 31.3% of grade 2, 56.3% of grade 3A, 100% of grade 3B, and 100% of grade 4 macroadenomas were found to have CSI intraoperatively. Two pituitary macroadenomas were classified as grade 4 on VIBE sequences but grades 3A and 2 on CISS sequences; CSI was not observed intraoperatively in both cases. The GTR rate was 64.3% and 60.0% for high-grade (3A, 3B, and 4) macroadenomas classified using VIBE and CISS sequences, respectively. The areas under the ROC curves were 0.94 and 0.97 for VIBE- and CISS-derived Knosp grades (p = 0.007), respectively.

CONCLUSIONS

Knosp grades determined using CISS sequence images are better correlated with intraoperative CSI than those determined using VIBE sequence images. CISS sequences may be valuable for the preoperative assessment of pituitary macroadenomas.

Authors+Show Affiliations

1School of Medicine, Case Western Reserve University. 3Department of Neurosurgery, Neurological Institute.3Department of Neurosurgery, Neurological Institute. 5Section of Rhinology, Sinus, and Skull Base Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio.2Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic.2Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic. 5Section of Rhinology, Sinus, and Skull Base Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio.3Department of Neurosurgery, Neurological Institute. 5Section of Rhinology, Sinus, and Skull Base Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio.3Department of Neurosurgery, Neurological Institute. 5Section of Rhinology, Sinus, and Skull Base Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio.2Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic. 5Section of Rhinology, Sinus, and Skull Base Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29570007

Citation

Lang, Min, et al. "Superiority of Constructive Interference in Steady-state MRI Sequencing Over T1-weighted MRI Sequencing for Evaluating Cavernous Sinus Invasion By Pituitary Macroadenomas." Journal of Neurosurgery, 2018, pp. 1-8.
Lang M, Silva D, Dai L, et al. Superiority of constructive interference in steady-state MRI sequencing over T1-weighted MRI sequencing for evaluating cavernous sinus invasion by pituitary macroadenomas. J Neurosurg. 2018.
Lang, M., Silva, D., Dai, L., Kshettry, V. R., Woodard, T. D., Sindwani, R., & Recinos, P. F. (2018). Superiority of constructive interference in steady-state MRI sequencing over T1-weighted MRI sequencing for evaluating cavernous sinus invasion by pituitary macroadenomas. Journal of Neurosurgery, pp. 1-8. doi:10.3171/2017.9.JNS171699.
Lang M, et al. Superiority of Constructive Interference in Steady-state MRI Sequencing Over T1-weighted MRI Sequencing for Evaluating Cavernous Sinus Invasion By Pituitary Macroadenomas. J Neurosurg. 2018 Mar 1;1-8. PubMed PMID: 29570007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superiority of constructive interference in steady-state MRI sequencing over T1-weighted MRI sequencing for evaluating cavernous sinus invasion by pituitary macroadenomas. AU - Lang,Min, AU - Silva,Danilo, AU - Dai,Lu, AU - Kshettry,Varun R, AU - Woodard,Troy D, AU - Sindwani,Raj, AU - Recinos,Pablo F, Y1 - 2018/03/01/ PY - 2017/07/29/received PY - 2017/09/11/accepted PY - 2018/3/24/pubmed PY - 2018/3/24/medline PY - 2018/3/24/entrez KW - AUC = area under the curve KW - CISS KW - CISS = constructive interference in steady state KW - CSI = cavernous sinus invasion KW - GTR = gross-total resection KW - ICA = internal carotid artery KW - Knosp grade KW - ROC = receiver operating characteristic KW - VIBE KW - VIBE = volume-interpolated breath-hold examination KW - constructive interference in steady state KW - endoscopic pituitary surgery KW - transsphenoidal surgery KW - volume interpolated breath-hold examination SP - 1 EP - 8 JF - Journal of neurosurgery JO - J. Neurosurg. N2 - OBJECTIVEPreoperatively determining the extent of parasellar invasion of pituitary macroadenomas is useful for surgical planning and patient counseling. Here, the authors compared constructive interference in steady state (CISS), a T2-weighted gradient-echo MRI sequence, to volume-interpolated breath-hold examination (VIBE), a T1-weighted gradient-echo MRI sequence, for evaluation of cavernous sinus invasion (CSI) by pituitary macroadenomas.METHODSVIBE and CISS images of 98 patients with pituitary macroadenoma were retrospectively analyzed and graded using the modified Knosp classification. The Knosp grades were correlated to surgical findings of CSI, which were determined intraoperatively using 0° and 30° endoscopes. The predictive accuracies for CSI according to the Knosp grades derived from the CISS and VIBE images were compared using receiver operating characteristic (ROC) curves. Postoperative MRI was used to evaluate the gross-total resection (GTR) rates.RESULTSThe CSI rate by pituitary macroadenomas was 27.6% (27 of 98 cases). Of 196 assessments (left and right sides of 98 macroadenomas), 45 (23.0%) had different Knosp grades when scored using VIBE versus CISS images. For the VIBE images, 0% of Knosp grade 0, 4.5% of grade 1, 23.8% of grade 2, 42.1% of grade 3A, 100% of grade 3B, and 83.3% of grade 4 macroadenomas were found to have CSI intraoperatively. For the CISS images, 0% of Knosp grade 0, 2.1% of grade 1, 31.3% of grade 2, 56.3% of grade 3A, 100% of grade 3B, and 100% of grade 4 macroadenomas were found to have CSI intraoperatively. Two pituitary macroadenomas were classified as grade 4 on VIBE sequences but grades 3A and 2 on CISS sequences; CSI was not observed intraoperatively in both cases. The GTR rate was 64.3% and 60.0% for high-grade (3A, 3B, and 4) macroadenomas classified using VIBE and CISS sequences, respectively. The areas under the ROC curves were 0.94 and 0.97 for VIBE- and CISS-derived Knosp grades (p = 0.007), respectively.CONCLUSIONSKnosp grades determined using CISS sequence images are better correlated with intraoperative CSI than those determined using VIBE sequence images. CISS sequences may be valuable for the preoperative assessment of pituitary macroadenomas. SN - 1933-0693 UR - https://www.unboundmedicine.com/medline/citation/29570007/Superiority_of_constructive_interference_in_steady_state_MRI_sequencing_over_T1_weighted_MRI_sequencing_for_evaluating_cavernous_sinus_invasion_by_pituitary_macroadenomas_ L2 - https://thejns.org/doi/10.3171/2017.9.JNS171699 DB - PRIME DP - Unbound Medicine ER -