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Risk Assessment of the Skin Sensitization Induction Potential of Kathon CG in Rinse-off and Leave-on Personal Care and Cosmetic Products.
Dermatitis. 2018 May/Jun; 29(3):132-138.D

Abstract

BACKGROUND

Kathon CG is a commonly used cosmetic-grade preservative that contains active ingredients methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI).

OBJECTIVE

The aim of the study was to perform a skin sensitization induction risk assessment of daily exposure to Kathon CG after use of various personal care and cosmetic products.

METHODS

We calculated an estimated daily consumer exposure level for rinse-off and leave-on products using the amount of product applied per application, number of applications per day, a retention factor, the MCI/MI concentration, and body surface area values. We assumed that the products contained the maximum recommended safe concentration of MCI/MI: 15 ppm in rinse-off products and 7.5 ppm in leave-on products. We compared estimated consumer exposure levels with the no expected sensitization induction level for MCI/MI and applied sensitization assessment factors to calculate product-specific margins of safety (MOSs).

CONCLUSIONS

The MOSs for rinse-off products ranged from 5 to 63, whereas the MOSs for leave-on products ranged from 0.03 to 1.49. Overall, our results provide evidence that some leave-on products containing the maximum recommended safe concentration of Kathon CG may increase the risk of sensitization induction due to exposure to MCI/MI. In contrast, rinse-off products were not associated with a potential increased risk of skin sensitization induction.

Authors+Show Affiliations

No affiliation info availableCardno ChemRisk, Boulder, CO.No affiliation info availableCardno ChemRisk, Aliso Viejo, CA.No affiliation info availableCardno ChemRisk, Jackson, WY.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29570489

Citation

Towle, Kevin M., et al. "Risk Assessment of the Skin Sensitization Induction Potential of Kathon CG in Rinse-off and Leave-on Personal Care and Cosmetic Products." Dermatitis : Contact, Atopic, Occupational, Drug, vol. 29, no. 3, 2018, pp. 132-138.
Towle KM, Drechsel DA, Warshaw EM, et al. Risk Assessment of the Skin Sensitization Induction Potential of Kathon CG in Rinse-off and Leave-on Personal Care and Cosmetic Products. Dermatitis. 2018;29(3):132-138.
Towle, K. M., Drechsel, D. A., Warshaw, E. M., Fung, E. S., Novick, R. M., Paustenbach, D. J., & Monnot, A. D. (2018). Risk Assessment of the Skin Sensitization Induction Potential of Kathon CG in Rinse-off and Leave-on Personal Care and Cosmetic Products. Dermatitis : Contact, Atopic, Occupational, Drug, 29(3), 132-138. https://doi.org/10.1097/DER.0000000000000359
Towle KM, et al. Risk Assessment of the Skin Sensitization Induction Potential of Kathon CG in Rinse-off and Leave-on Personal Care and Cosmetic Products. Dermatitis. 2018 May/Jun;29(3):132-138. PubMed PMID: 29570489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk Assessment of the Skin Sensitization Induction Potential of Kathon CG in Rinse-off and Leave-on Personal Care and Cosmetic Products. AU - Towle,Kevin M, AU - Drechsel,Derek A, AU - Warshaw,Erin M, AU - Fung,Ernest S, AU - Novick,Rachel M, AU - Paustenbach,Dennis J, AU - Monnot,Andrew D, PY - 2018/3/24/pubmed PY - 2018/10/26/medline PY - 2018/3/24/entrez SP - 132 EP - 138 JF - Dermatitis : contact, atopic, occupational, drug JO - Dermatitis VL - 29 IS - 3 N2 - BACKGROUND: Kathon CG is a commonly used cosmetic-grade preservative that contains active ingredients methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI). OBJECTIVE: The aim of the study was to perform a skin sensitization induction risk assessment of daily exposure to Kathon CG after use of various personal care and cosmetic products. METHODS: We calculated an estimated daily consumer exposure level for rinse-off and leave-on products using the amount of product applied per application, number of applications per day, a retention factor, the MCI/MI concentration, and body surface area values. We assumed that the products contained the maximum recommended safe concentration of MCI/MI: 15 ppm in rinse-off products and 7.5 ppm in leave-on products. We compared estimated consumer exposure levels with the no expected sensitization induction level for MCI/MI and applied sensitization assessment factors to calculate product-specific margins of safety (MOSs). CONCLUSIONS: The MOSs for rinse-off products ranged from 5 to 63, whereas the MOSs for leave-on products ranged from 0.03 to 1.49. Overall, our results provide evidence that some leave-on products containing the maximum recommended safe concentration of Kathon CG may increase the risk of sensitization induction due to exposure to MCI/MI. In contrast, rinse-off products were not associated with a potential increased risk of skin sensitization induction. SN - 2162-5220 UR - https://www.unboundmedicine.com/medline/citation/29570489/Risk_Assessment_of_the_Skin_Sensitization_Induction_Potential_of_Kathon_CG_in_Rinse_off_and_Leave_on_Personal_Care_and_Cosmetic_Products_ L2 - http://dx.doi.org/10.1097/DER.0000000000000359 DB - PRIME DP - Unbound Medicine ER -