Tags

Type your tag names separated by a space and hit enter

The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial.
Diabetes Metab Syndr. 2018 Jul; 12(4):483-489.DM

Abstract

BACKGROUND AND AIM

Recently, there has been an increasing interest in the influence of antioxidant vitamins on the efficacy of oral hypoglycemic therapy in type 2 diabetic patients (T2DM). This single-blinded randomized controlled clinical trial aimed to investigate the effect of vitamin C and/or E supplementation on the efficacy of oral hypoglycemic therapy in T2DM Palestinian male patients from the Gaza Strip.

METHODS

Forty T2DM male patients aged 40-60 years on metformin treatment were randomly divided into four groups, each group received an additional one of the following daily oral supplements for 90 days: placebo; vitamin C; vitamin E and vitamin C plus vitamin E. After overnight fasting, venous blood specimens were collected from all individuals into K3-EDTA tubes and serum tubes for measuring the biochemical and hematological parameters of the study at baseline and after 90 days of vitamins supplementation.

RESULTS

The results revealed that vitamin C and/or E improve fasting blood sugar (FBS), HbA1c, lipid profile, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), reduced glutathione (GSH); and Quantitative Insulin Sensitivity Check Index (QISCI) compared with diabetic patients group that received placebo.

CONCLUSION

This study provided additional evidence on the beneficial effects of supplementing antioxidant vitamins in T2DM which could improve the clinical condition and attenuate or prevent diabetic pathogenesis and complications that, secondly to poor glycemic control, could attribute to the imbalance between the decline in the endogenous antioxidants and increasing production of the reactive oxygen species leading to the oxidant-mediated damage present in the diabetic context.

Authors+Show Affiliations

Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.Directorate of Central Laboratories, Palestinian Ministry of Health, Gaza, Palestine.Faculty of Medicine, Al Azhar University Gaza, Ministry of Health, Palestine.Biology Department, Faculty of Science, Al Azhar University, Gaza, Palestine. Electronic address: msirdah@hotmail.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29571976

Citation

El-Aal, Ali Abd, et al. "The Effect of Vitamin C And/or E Supplementations On Type 2 Diabetic Adult Males Under Metformin Treatment: a Single-blinded Randomized Controlled Clinical Trial." Diabetes & Metabolic Syndrome, vol. 12, no. 4, 2018, pp. 483-489.
El-Aal AA, El-Ghffar EAA, Ghali AA, et al. The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial. Diabetes Metab Syndr. 2018;12(4):483-489.
El-Aal, A. A., El-Ghffar, E. A. A., Ghali, A. A., Zughbur, M. R., & Sirdah, M. M. (2018). The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial. Diabetes & Metabolic Syndrome, 12(4), 483-489. https://doi.org/10.1016/j.dsx.2018.03.013
El-Aal AA, et al. The Effect of Vitamin C And/or E Supplementations On Type 2 Diabetic Adult Males Under Metformin Treatment: a Single-blinded Randomized Controlled Clinical Trial. Diabetes Metab Syndr. 2018;12(4):483-489. PubMed PMID: 29571976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial. AU - El-Aal,Ali Abd, AU - El-Ghffar,Eman A Abd, AU - Ghali,Asmaa Abu, AU - Zughbur,Mohammed R, AU - Sirdah,Mahmoud M, Y1 - 2018/03/16/ PY - 2018/01/23/received PY - 2018/03/15/accepted PY - 2018/3/25/pubmed PY - 2018/11/9/medline PY - 2018/3/25/entrez KW - Antioxidants KW - Insulin KW - Oxidative stress KW - Type 2 diabetes KW - Vitamin C KW - Vitamin E SP - 483 EP - 489 JF - Diabetes & metabolic syndrome JO - Diabetes Metab Syndr VL - 12 IS - 4 N2 - BACKGROUND AND AIM: Recently, there has been an increasing interest in the influence of antioxidant vitamins on the efficacy of oral hypoglycemic therapy in type 2 diabetic patients (T2DM). This single-blinded randomized controlled clinical trial aimed to investigate the effect of vitamin C and/or E supplementation on the efficacy of oral hypoglycemic therapy in T2DM Palestinian male patients from the Gaza Strip. METHODS: Forty T2DM male patients aged 40-60 years on metformin treatment were randomly divided into four groups, each group received an additional one of the following daily oral supplements for 90 days: placebo; vitamin C; vitamin E and vitamin C plus vitamin E. After overnight fasting, venous blood specimens were collected from all individuals into K3-EDTA tubes and serum tubes for measuring the biochemical and hematological parameters of the study at baseline and after 90 days of vitamins supplementation. RESULTS: The results revealed that vitamin C and/or E improve fasting blood sugar (FBS), HbA1c, lipid profile, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), reduced glutathione (GSH); and Quantitative Insulin Sensitivity Check Index (QISCI) compared with diabetic patients group that received placebo. CONCLUSION: This study provided additional evidence on the beneficial effects of supplementing antioxidant vitamins in T2DM which could improve the clinical condition and attenuate or prevent diabetic pathogenesis and complications that, secondly to poor glycemic control, could attribute to the imbalance between the decline in the endogenous antioxidants and increasing production of the reactive oxygen species leading to the oxidant-mediated damage present in the diabetic context. SN - 1878-0334 UR - https://www.unboundmedicine.com/medline/citation/29571976/The_effect_of_vitamin_C_and/or_E_supplementations_on_type_2_diabetic_adult_males_under_metformin_treatment:_A_single_blinded_randomized_controlled_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1871-4021(18)30043-2 DB - PRIME DP - Unbound Medicine ER -