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Short-interval and long-interval intracortical inhibition of TMS-evoked EEG potentials.
Brain Stimul 2018 Jul - Aug; 11(4):818-827BS

Abstract

BACKGROUND

Inhibition in the human motor cortex can be probed by means of paired-pulse transcranial magnetic stimulation (ppTMS) at interstimulus intervals of 2-3 ms (short-interval intracortical inhibition, SICI) or ∼100 ms (long-interval intracortical inhibition, LICI). Conventionally, SICI and LICI are recorded as motor evoked potential (MEP) inhibition in the hand muscle. Pharmacological experiments indicate that they are mediated by GABAA and GABAB receptors, respectively.

OBJECTIVE/HYPOTHESIS

SICI and LICI of TMS-evoked EEG potentials (TEPs) and their pharmacological properties have not been systematically studied. Here, we sought to examine SICI by ppTMS-evoked compared to single-pulse TMS-evoked TEPs, to investigate its pharmacological manipulation and to compare SICI with our previous results on LICI.

METHODS

PpTMS-EEG was applied to the left motor cortex in 16 healthy subjects in a randomized, double-blind placebo-controlled crossover design, testing the effects of a single oral dose 20 mg of diazepam, a positive modulator at the GABAA receptor, vs. 50 mg of the GABAB receptor agonist baclofen on SICI of TEPs.

RESULTS

We found significant SICI of the N100 and P180 TEPs prior to drug intake. Diazepam reduced SICI of the N100 TEP, while baclofen enhanced it. Compared to our previous ppTMS-EEG results on LICI, the SICI effects on TEPs, including their drug modulation, were largely analogous.

CONCLUSIONS

Findings suggest a similar interaction of paired-pulse effects on TEPs irrespective of the interstimulus interval. Therefore, SICI and LICI as measured with TEPs cannot be directly derived from SICI and LICI measured with MEPs, but may offer novel insight into paired-pulse responses recorded directly from the brain rather than muscle.

Authors+Show Affiliations

Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany.Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany.Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany.Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany.Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany. Electronic address: ulf.ziemann@uni-tuebingen.de.Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29572124

Citation

Premoli, Isabella, et al. "Short-interval and Long-interval Intracortical Inhibition of TMS-evoked EEG Potentials." Brain Stimulation, vol. 11, no. 4, 2018, pp. 818-827.
Premoli I, Király J, Müller-Dahlhaus F, et al. Short-interval and long-interval intracortical inhibition of TMS-evoked EEG potentials. Brain Stimul. 2018;11(4):818-827.
Premoli, I., Király, J., Müller-Dahlhaus, F., Zipser, C. M., Rossini, P., Zrenner, C., ... Belardinelli, P. (2018). Short-interval and long-interval intracortical inhibition of TMS-evoked EEG potentials. Brain Stimulation, 11(4), pp. 818-827. doi:10.1016/j.brs.2018.03.008.
Premoli I, et al. Short-interval and Long-interval Intracortical Inhibition of TMS-evoked EEG Potentials. Brain Stimul. 2018;11(4):818-827. PubMed PMID: 29572124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-interval and long-interval intracortical inhibition of TMS-evoked EEG potentials. AU - Premoli,Isabella, AU - Király,Julia, AU - Müller-Dahlhaus,Florian, AU - Zipser,Carl M, AU - Rossini,Pierre, AU - Zrenner,Christoph, AU - Ziemann,Ulf, AU - Belardinelli,Paolo, Y1 - 2018/03/15/ PY - 2017/07/26/received PY - 2018/03/02/revised PY - 2018/03/13/accepted PY - 2018/3/25/pubmed PY - 2019/3/21/medline PY - 2018/3/25/entrez KW - Baclofen KW - Diazepam KW - GABA KW - Long-interval intracortical inhibition KW - Paired-pulse transcranial magnetic stimulation KW - Short-interval intracortical inhibition KW - TMS-Evoked EEG potential SP - 818 EP - 827 JF - Brain stimulation JO - Brain Stimul VL - 11 IS - 4 N2 - BACKGROUND: Inhibition in the human motor cortex can be probed by means of paired-pulse transcranial magnetic stimulation (ppTMS) at interstimulus intervals of 2-3 ms (short-interval intracortical inhibition, SICI) or ∼100 ms (long-interval intracortical inhibition, LICI). Conventionally, SICI and LICI are recorded as motor evoked potential (MEP) inhibition in the hand muscle. Pharmacological experiments indicate that they are mediated by GABAA and GABAB receptors, respectively. OBJECTIVE/HYPOTHESIS: SICI and LICI of TMS-evoked EEG potentials (TEPs) and their pharmacological properties have not been systematically studied. Here, we sought to examine SICI by ppTMS-evoked compared to single-pulse TMS-evoked TEPs, to investigate its pharmacological manipulation and to compare SICI with our previous results on LICI. METHODS: PpTMS-EEG was applied to the left motor cortex in 16 healthy subjects in a randomized, double-blind placebo-controlled crossover design, testing the effects of a single oral dose 20 mg of diazepam, a positive modulator at the GABAA receptor, vs. 50 mg of the GABAB receptor agonist baclofen on SICI of TEPs. RESULTS: We found significant SICI of the N100 and P180 TEPs prior to drug intake. Diazepam reduced SICI of the N100 TEP, while baclofen enhanced it. Compared to our previous ppTMS-EEG results on LICI, the SICI effects on TEPs, including their drug modulation, were largely analogous. CONCLUSIONS: Findings suggest a similar interaction of paired-pulse effects on TEPs irrespective of the interstimulus interval. Therefore, SICI and LICI as measured with TEPs cannot be directly derived from SICI and LICI measured with MEPs, but may offer novel insight into paired-pulse responses recorded directly from the brain rather than muscle. SN - 1876-4754 UR - https://www.unboundmedicine.com/medline/citation/29572124/Short_interval_and_long_interval_intracortical_inhibition_of_TMS_evoked_EEG_potentials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1935-861X(18)30091-3 DB - PRIME DP - Unbound Medicine ER -