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Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic.
Med Mal Infect. 2018 Jun; 48(4):263-268.MM

Abstract

BACKGROUND

Monkeypox is a zoonosis caused by an Orthopoxvirus of the Poxviridae family. Human infections are often severe and are a public health problem.

PATIENTS AND METHOD

We conducted a monkeypox outbreak investigation of suspected case patients in five villages of the Alindao-Mingala Health District following blood sample confirmation of the virus by the Institut Pasteur in Bangui. We aimed to determine disease characteristics, to describe the context and the risk factors, and to measure the incidence and case fatality. Patients were reported in the villages of Rehou 4, 5, Dalakere 1, Kongbo, and Pavika from August to October 2016. Data was collected on individual records when interviewing patients or parents.

RESULTS

A total of 26 patients were identified. The˂10 years and 21-30 years age groups were the most affected. The overall attack rate was 5 per 1000 inhabitants and the case fatality was 7.7%. Young age and the absence of smallpox vaccination were associated with severe presentations in 87.5% of cases.

CONCLUSION

The annual number of monkeypox outbreaks increases in the Central African Republic with severe presentations and a high case fatality especially in children. Reinforcing the surveillance and characterization of circulating strains will provide information on the need for vaccine production.

Authors+Show Affiliations

Direction de la région sanitaire N(o)6, Central African Republic. Electronic address: kalthanernest@yahoo.fr.Centre d'opération d'urgence en santé publique (RCA), Central African Republic.Service de la surveillance épidémiologique intégrée, de gestion des épidémies et des situations d'urgence (RCA), Central African Republic.Organisation Mondiale de la Santé (Bangui), Central African Republic.District d'Alindao-Mingala, Central African Republic.Cordaid Alindao, Central African Republic.Centre d'opération d'urgence en santé publique (RCA), Central African Republic.Hôpital de l'Amitié, Central African Republic.District d'Alindao-Mingala, Central African Republic.International Medical Corps (BRIA), Central African Republic.Institut Pasteur de Bangui, Central African Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29573840

Citation

Kalthan, E, et al. "Investigation of an Outbreak of Monkeypox in an Area Occupied By Armed Groups, Central African Republic." Medecine Et Maladies Infectieuses, vol. 48, no. 4, 2018, pp. 263-268.
Kalthan E, Tenguere J, Ndjapou SG, et al. Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic. Med Mal Infect. 2018;48(4):263-268.
Kalthan, E., Tenguere, J., Ndjapou, S. G., Koyazengbe, T. A., Mbomba, J., Marada, R. M., Rombebe, P., Yangueme, P., Babamingui, M., Sambella, A., & Nakoune, E. R. (2018). Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic. Medecine Et Maladies Infectieuses, 48(4), 263-268. https://doi.org/10.1016/j.medmal.2018.02.010
Kalthan E, et al. Investigation of an Outbreak of Monkeypox in an Area Occupied By Armed Groups, Central African Republic. Med Mal Infect. 2018;48(4):263-268. PubMed PMID: 29573840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic. AU - Kalthan,E, AU - Tenguere,J, AU - Ndjapou,S G, AU - Koyazengbe,T A, AU - Mbomba,J, AU - Marada,R M, AU - Rombebe,P, AU - Yangueme,P, AU - Babamingui,M, AU - Sambella,A, AU - Nakoune,E R, Y1 - 2018/03/21/ PY - 2017/01/20/received PY - 2017/06/01/revised PY - 2018/02/27/accepted PY - 2018/3/27/pubmed PY - 2019/6/18/medline PY - 2018/3/26/entrez KW - Monkeypox KW - Outbreak KW - Zoonose KW - Zoonoses KW - Épidémie SP - 263 EP - 268 JF - Medecine et maladies infectieuses JO - Med Mal Infect VL - 48 IS - 4 N2 - BACKGROUND: Monkeypox is a zoonosis caused by an Orthopoxvirus of the Poxviridae family. Human infections are often severe and are a public health problem. PATIENTS AND METHOD: We conducted a monkeypox outbreak investigation of suspected case patients in five villages of the Alindao-Mingala Health District following blood sample confirmation of the virus by the Institut Pasteur in Bangui. We aimed to determine disease characteristics, to describe the context and the risk factors, and to measure the incidence and case fatality. Patients were reported in the villages of Rehou 4, 5, Dalakere 1, Kongbo, and Pavika from August to October 2016. Data was collected on individual records when interviewing patients or parents. RESULTS: A total of 26 patients were identified. The˂10 years and 21-30 years age groups were the most affected. The overall attack rate was 5 per 1000 inhabitants and the case fatality was 7.7%. Young age and the absence of smallpox vaccination were associated with severe presentations in 87.5% of cases. CONCLUSION: The annual number of monkeypox outbreaks increases in the Central African Republic with severe presentations and a high case fatality especially in children. Reinforcing the surveillance and characterization of circulating strains will provide information on the need for vaccine production. SN - 1769-6690 UR - https://www.unboundmedicine.com/medline/citation/29573840/Investigation_of_an_outbreak_of_monkeypox_in_an_area_occupied_by_armed_groups_Central_African_Republic_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0399-077X(17)30026-4 DB - PRIME DP - Unbound Medicine ER -