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Evaluation of three rapid oral fluid test devices on the screening of multiple drugs of abuse including ketamine.
Forensic Sci Int. 2018 May; 286:113-120.FS

Abstract

Rapid oral fluid testing (ROFT) devices have been extensively evaluated for their ability to detect common drugs of abuse; however, the performance of such devices on simultaneous screening for ketamine has been scarcely investigated. The present study evaluated three ROFT devices (DrugWipe® 6S, Ora-Check® and SalivaScreen®) on the detection of ketamine, opiates, methamphetamine, cannabis, cocaine and MDMA. A liquid chromatography tandem mass spectrometry (LCMS) assay was firstly established and validated for confirmation analysis of the six types of drugs and/or their metabolites. In the field test, the three ROFT devices were tested on subjects recruited from substance abuse clinics/rehabilitation centre. Oral fluid was also collected using Quantisal® for confirmation analysis. A total of 549 samples were collected in the study. LCMS analysis on 491 samples revealed the following drugs: codeine (55%), morphine (49%), heroin (40%), methamphetamine (35%), THC (8%), ketamine (4%) and cocaine (2%). No MDMA-positive cases were observed. Results showed that the overall specificity and accuracy were satisfactory and met the DRUID standard of >80% for all 3 devices. Ora-Check® had poor sensitivities (ketamine 36%, methamphetamine 63%, opiates 53%, cocaine 60%, THC 0%). DrugWipe® 6S showed good sensitivities in the methamphetamine (83%) and opiates (93%) tests but performed relatively poorly for ketamine (41%), cocaine (43%) and THC (22%). SalivaScreen® also demonstrated good sensitivities in the methamphetamine (83%) and opiates (100%) tests, and had the highest sensitivity for ketamine (76%) and cocaine (71%); however, it failed to detect any of the 28 THC-positive cases. The test completion rate (proportion of tests completed with quality control passed) were: 52% (Ora-Check®), 78% (SalivaScreen®) and 99% (DrugWipe® 6S).

Authors+Show Affiliations

Hospital Authority Toxicology Reference Laboratory, Hong Kong, China. Electronic address: thy415@ha.org.hk.Hospital Authority Toxicology Reference Laboratory, Hong Kong, China. Electronic address: chingck2@ha.org.hk.Hospital Authority Toxicology Reference Laboratory, Hong Kong, China. Electronic address: poonpy2@ha.org.hk.Hospital Authority Toxicology Reference Laboratory, Hong Kong, China. Electronic address: chanss02@ha.org.hk.Hospital Authority Toxicology Reference Laboratory, Hong Kong, China. Electronic address: nwy518@ha.org.hk.Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong, China. Electronic address: lm349@ha.org.hk.Department of Psychiatry, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Electronic address: wck227@ha.org.hk.Substance Abuse Assessment Unit, Kwai Chung Hospital, Hong Kong, China. Electronic address: paosy@ha.org.hk.The Society of Rehabilitation and Crime Prevention, Hong Kong, China. Electronic address: pic_care@sracp.org.hk.Hospital Authority Toxicology Reference Laboratory, Hong Kong, China. Electronic address: makwl@ha.org.hk.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

29574346

Citation

Tang, Magdalene H Y., et al. "Evaluation of Three Rapid Oral Fluid Test Devices On the Screening of Multiple Drugs of Abuse Including Ketamine." Forensic Science International, vol. 286, 2018, pp. 113-120.
Tang MHY, Ching CK, Poon S, et al. Evaluation of three rapid oral fluid test devices on the screening of multiple drugs of abuse including ketamine. Forensic Sci Int. 2018;286:113-120.
Tang, M. H. Y., Ching, C. K., Poon, S., Chan, S. S. S., Ng, W. Y., Lam, M., Wong, C. K., Pao, R., Lau, A., & Mak, T. W. L. (2018). Evaluation of three rapid oral fluid test devices on the screening of multiple drugs of abuse including ketamine. Forensic Science International, 286, 113-120. https://doi.org/10.1016/j.forsciint.2018.03.004
Tang MHY, et al. Evaluation of Three Rapid Oral Fluid Test Devices On the Screening of Multiple Drugs of Abuse Including Ketamine. Forensic Sci Int. 2018;286:113-120. PubMed PMID: 29574346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of three rapid oral fluid test devices on the screening of multiple drugs of abuse including ketamine. AU - Tang,Magdalene H Y, AU - Ching,C K, AU - Poon,Simon, AU - Chan,Suzanne S S, AU - Ng,W Y, AU - Lam,M, AU - Wong,C K, AU - Pao,Ronnie, AU - Lau,Angus, AU - Mak,Tony W L, Y1 - 2018/03/12/ PY - 2017/12/14/received PY - 2018/02/23/revised PY - 2018/03/02/accepted PY - 2018/3/27/pubmed PY - 2018/7/14/medline PY - 2018/3/26/entrez KW - Drugged driving KW - Drugs of abuse KW - Ketamine KW - Kit evaluation KW - Oral fluid KW - Rapid screening SP - 113 EP - 120 JF - Forensic science international JO - Forensic Sci Int VL - 286 N2 - Rapid oral fluid testing (ROFT) devices have been extensively evaluated for their ability to detect common drugs of abuse; however, the performance of such devices on simultaneous screening for ketamine has been scarcely investigated. The present study evaluated three ROFT devices (DrugWipe® 6S, Ora-Check® and SalivaScreen®) on the detection of ketamine, opiates, methamphetamine, cannabis, cocaine and MDMA. A liquid chromatography tandem mass spectrometry (LCMS) assay was firstly established and validated for confirmation analysis of the six types of drugs and/or their metabolites. In the field test, the three ROFT devices were tested on subjects recruited from substance abuse clinics/rehabilitation centre. Oral fluid was also collected using Quantisal® for confirmation analysis. A total of 549 samples were collected in the study. LCMS analysis on 491 samples revealed the following drugs: codeine (55%), morphine (49%), heroin (40%), methamphetamine (35%), THC (8%), ketamine (4%) and cocaine (2%). No MDMA-positive cases were observed. Results showed that the overall specificity and accuracy were satisfactory and met the DRUID standard of >80% for all 3 devices. Ora-Check® had poor sensitivities (ketamine 36%, methamphetamine 63%, opiates 53%, cocaine 60%, THC 0%). DrugWipe® 6S showed good sensitivities in the methamphetamine (83%) and opiates (93%) tests but performed relatively poorly for ketamine (41%), cocaine (43%) and THC (22%). SalivaScreen® also demonstrated good sensitivities in the methamphetamine (83%) and opiates (100%) tests, and had the highest sensitivity for ketamine (76%) and cocaine (71%); however, it failed to detect any of the 28 THC-positive cases. The test completion rate (proportion of tests completed with quality control passed) were: 52% (Ora-Check®), 78% (SalivaScreen®) and 99% (DrugWipe® 6S). SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/29574346/Evaluation_of_three_rapid_oral_fluid_test_devices_on_the_screening_of_multiple_drugs_of_abuse_including_ketamine_ DB - PRIME DP - Unbound Medicine ER -