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The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea.
Elife. 2018 03 27; 7E

Abstract

Giant viruses are ecologically important players in aquatic ecosystems that have challenged concepts of what constitutes a virus. Herein, we present the giant Bodo saltans virus (BsV), the first characterized representative of the most abundant group of giant viruses in ocean metagenomes, and the first isolate of a klosneuvirus, a subgroup of the Mimiviridae proposed from metagenomic data. BsV infects an ecologically important microzooplankton, the kinetoplastid Bodo saltans. Its 1.39 Mb genome encodes 1227 predicted ORFs, including a complex replication machinery. Yet, much of its translational apparatus has been lost, including all tRNAs. Essential genes are invaded by homing endonuclease-encoding self-splicing introns that may defend against competing viruses. Putative anti-host factors show extensive gene duplication via a genomic accordion indicating an ongoing evolutionary arms race and highlighting the rapid evolution and genomic plasticity that has led to genome gigantism and the enigma that is giant viruses.

Authors+Show Affiliations

Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada.Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada. Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada. Department of Botany, University of British Columbia, Vancouver, Canada. Institute for the Oceans and Fisheries, University of British Columbia, Vancouver, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29582753

Citation

Deeg, Christoph M., et al. "The Kinetoplastid-infecting Bodo Saltans Virus (BsV), a Window Into the Most Abundant Giant Viruses in the Sea." ELife, vol. 7, 2018.
Deeg CM, Chow CT, Suttle CA. The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea. Elife. 2018;7.
Deeg, C. M., Chow, C. T., & Suttle, C. A. (2018). The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea. ELife, 7. https://doi.org/10.7554/eLife.33014
Deeg CM, Chow CT, Suttle CA. The Kinetoplastid-infecting Bodo Saltans Virus (BsV), a Window Into the Most Abundant Giant Viruses in the Sea. Elife. 2018 03 27;7 PubMed PMID: 29582753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea. AU - Deeg,Christoph M, AU - Chow,Cheryl-Emiliane T, AU - Suttle,Curtis A, Y1 - 2018/03/27/ PY - 2017/10/22/received PY - 2018/02/22/accepted PY - 2018/3/28/entrez PY - 2018/3/28/pubmed PY - 2019/6/1/medline KW - Bodo saltans KW - Bodo saltans virus KW - Giant Viruses KW - NCLDV KW - evolutionary biology KW - genomics KW - infectious disease KW - microbiology JF - eLife JO - Elife VL - 7 N2 - Giant viruses are ecologically important players in aquatic ecosystems that have challenged concepts of what constitutes a virus. Herein, we present the giant Bodo saltans virus (BsV), the first characterized representative of the most abundant group of giant viruses in ocean metagenomes, and the first isolate of a klosneuvirus, a subgroup of the Mimiviridae proposed from metagenomic data. BsV infects an ecologically important microzooplankton, the kinetoplastid Bodo saltans. Its 1.39 Mb genome encodes 1227 predicted ORFs, including a complex replication machinery. Yet, much of its translational apparatus has been lost, including all tRNAs. Essential genes are invaded by homing endonuclease-encoding self-splicing introns that may defend against competing viruses. Putative anti-host factors show extensive gene duplication via a genomic accordion indicating an ongoing evolutionary arms race and highlighting the rapid evolution and genomic plasticity that has led to genome gigantism and the enigma that is giant viruses. SN - 2050-084X UR - https://www.unboundmedicine.com/medline/citation/29582753/The_kinetoplastid_infecting_Bodo_saltans_virus__BsV__a_window_into_the_most_abundant_giant_viruses_in_the_sea_ L2 - https://doi.org/10.7554/eLife.33014 DB - PRIME DP - Unbound Medicine ER -