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Gut Microbiota and Type 1 Diabetes.
Int J Mol Sci. 2018 Mar 27; 19(4)IJ

Abstract

Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed.

Authors+Show Affiliations

Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. hanhui16@mails.ucas.ac.cn. University of Chinese Academy of Sciences, Beijing 100039, China. hanhui16@mails.ucas.ac.cn.Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. liyuying@mails.ucas.ac.cn. University of Chinese Academy of Sciences, Beijing 100039, China. liyuying@mails.ucas.ac.cn.College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. fangjun1973@hunau.edu.cn.Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. gangle.liu@gmail.com.Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. yinjie2014@126.com. University of Chinese Academy of Sciences, Beijing 100039, China. yinjie2014@126.com.Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. tjli@isa.ac.cn. Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China. tjli@isa.ac.cn.Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. yinyulonsg@isa.ac.cn. Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China. yinyulonsg@isa.ac.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29584630

Citation

Han, Hui, et al. "Gut Microbiota and Type 1 Diabetes." International Journal of Molecular Sciences, vol. 19, no. 4, 2018.
Han H, Li Y, Fang J, et al. Gut Microbiota and Type 1 Diabetes. Int J Mol Sci. 2018;19(4).
Han, H., Li, Y., Fang, J., Liu, G., Yin, J., Li, T., & Yin, Y. (2018). Gut Microbiota and Type 1 Diabetes. International Journal of Molecular Sciences, 19(4). https://doi.org/10.3390/ijms19040995
Han H, et al. Gut Microbiota and Type 1 Diabetes. Int J Mol Sci. 2018 Mar 27;19(4) PubMed PMID: 29584630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gut Microbiota and Type 1 Diabetes. AU - Han,Hui, AU - Li,Yuying, AU - Fang,Jun, AU - Liu,Gang, AU - Yin,Jie, AU - Li,Tiejun, AU - Yin,Yulong, Y1 - 2018/03/27/ PY - 2018/01/17/received PY - 2018/02/27/revised PY - 2018/03/02/accepted PY - 2018/3/28/entrez PY - 2018/3/28/pubmed PY - 2018/9/5/medline KW - diet KW - gut microbiota KW - hormones KW - immune response KW - type 1 diabetes JF - International journal of molecular sciences JO - Int J Mol Sci VL - 19 IS - 4 N2 - Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/29584630/Gut_Microbiota_and_Type_1_Diabetes_ L2 - http://www.mdpi.com/resolver?pii=ijms19040995 DB - PRIME DP - Unbound Medicine ER -