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Chemical characterization and biological activity in young sesame leaves (Sesamum indicum L.) and changes in iridoid and polyphenol content at different growth stages.
PLoS One. 2018; 13(3):e0194449.Plos

Abstract

Three iridoids (lamalbid (I1), sesamoside (I2) and shanzhiside methyl ester (I3)) and seven polyphenols (cistanoside F (P1), chlorogenic acid (P2), pedalitin-6-O-laminaribioside (P3), pedaliin (P4), isoacteoside (P6), pedalitin (P7) and martynoside (P8)) were identified in young sesame leaves (Sesamum indicum L.) other than the acteoside (P5) reported previously. P3 was a new compound, and I1, I3, P2 and P8 were found in a species of Sesamum for the first time. HPLC analyses revealed that the compounds I1 (0.29-1.75% of dry leaves), I2 (0.38-0.87%), I3 (0.04-1.07%), P4 (0.01-2.05%) and P5 (0.13-4.86%) were present primarily in young sesame leaves and were found in plants cultivated on different farms (plant height, 30-70 cm). Of the identified compounds, P5 and P6 showed high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, oxygen radical absorbance capacity (ORAC), and in vitro antiglycation activities. Given its content, P5 makes a major contribution to the biological activities of young sesame leaves. The compounds were examined at six different growth stages of plants cultured in a greenhouse to determine the optimum harvest stage and for end-use assessment. P5 accumulated in the leaves during growth, and the content reached a maximum of 12.9% of dry leaves in the 4th stage (plant height, 74.5±9.7 cm), which is one of the highest percentages reported in plants from nature.

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Authors+Show Affiliations

Fuji Y
Department of Food Bioscience and Biotechnology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Uchida A
Wadaman Science Co., Ltd, Nijoden-cho, Nakagyo-ku, Kyoto, Japan.
Fukahori K
Wadaman Science Co., Ltd, Nijoden-cho, Nakagyo-ku, Kyoto, Japan.
Chino M
Department of Food Bioscience and Biotechnology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Ohtsuki T
Department of Food Bioscience and Biotechnology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Matsufuji H
Department of Food Bioscience and Biotechnology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.

MeSH

AnimalsAntioxidantsCattlePlant LeavesPolyphenolsSesamum

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29584748

Citation

Fuji, Yushiro, et al. "Chemical Characterization and Biological Activity in Young Sesame Leaves (Sesamum Indicum L.) and Changes in Iridoid and Polyphenol Content at Different Growth Stages." PloS One, vol. 13, no. 3, 2018, pp. e0194449.
Fuji Y, Uchida A, Fukahori K, et al. Chemical characterization and biological activity in young sesame leaves (Sesamum indicum L.) and changes in iridoid and polyphenol content at different growth stages. PLoS One. 2018;13(3):e0194449.
Fuji, Y., Uchida, A., Fukahori, K., Chino, M., Ohtsuki, T., & Matsufuji, H. (2018). Chemical characterization and biological activity in young sesame leaves (Sesamum indicum L.) and changes in iridoid and polyphenol content at different growth stages. PloS One, 13(3), e0194449. https://doi.org/10.1371/journal.pone.0194449
Fuji Y, et al. Chemical Characterization and Biological Activity in Young Sesame Leaves (Sesamum Indicum L.) and Changes in Iridoid and Polyphenol Content at Different Growth Stages. PLoS One. 2018;13(3):e0194449. PubMed PMID: 29584748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical characterization and biological activity in young sesame leaves (Sesamum indicum L.) and changes in iridoid and polyphenol content at different growth stages. AU - Fuji,Yushiro, AU - Uchida,Ayumi, AU - Fukahori,Katsunori, AU - Chino,Makoto, AU - Ohtsuki,Takashi, AU - Matsufuji,Hiroshi, Y1 - 2018/03/27/ PY - 2017/12/08/received PY - 2018/03/02/accepted PY - 2018/3/28/entrez PY - 2018/3/28/pubmed PY - 2018/7/10/medline SP - e0194449 EP - e0194449 JF - PloS one JO - PLoS One VL - 13 IS - 3 N2 - Three iridoids (lamalbid (I1), sesamoside (I2) and shanzhiside methyl ester (I3)) and seven polyphenols (cistanoside F (P1), chlorogenic acid (P2), pedalitin-6-O-laminaribioside (P3), pedaliin (P4), isoacteoside (P6), pedalitin (P7) and martynoside (P8)) were identified in young sesame leaves (Sesamum indicum L.) other than the acteoside (P5) reported previously. P3 was a new compound, and I1, I3, P2 and P8 were found in a species of Sesamum for the first time. HPLC analyses revealed that the compounds I1 (0.29-1.75% of dry leaves), I2 (0.38-0.87%), I3 (0.04-1.07%), P4 (0.01-2.05%) and P5 (0.13-4.86%) were present primarily in young sesame leaves and were found in plants cultivated on different farms (plant height, 30-70 cm). Of the identified compounds, P5 and P6 showed high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, oxygen radical absorbance capacity (ORAC), and in vitro antiglycation activities. Given its content, P5 makes a major contribution to the biological activities of young sesame leaves. The compounds were examined at six different growth stages of plants cultured in a greenhouse to determine the optimum harvest stage and for end-use assessment. P5 accumulated in the leaves during growth, and the content reached a maximum of 12.9% of dry leaves in the 4th stage (plant height, 74.5±9.7 cm), which is one of the highest percentages reported in plants from nature. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/29584748/Chemical_characterization_and_biological_activity_in_young_sesame_leaves__Sesamum_indicum_L___and_changes_in_iridoid_and_polyphenol_content_at_different_growth_stages_ DB - PRIME DP - Unbound Medicine ER -