Tags

Type your tag names separated by a space and hit enter

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis.
Nutrients. 2018 Mar 26; 10(4)N

Abstract

Influenza virus infection is a major global public health problem, and the efficacy of influenza vaccination is not satisfactory. Vitamin D is involved in many immune-mediated inflammatory processes. The impact of vitamin D levels on the immunogenic response to influenza vaccination is not clear. We performed a comprehensive literature search and systematic review of studies that investigated vitamin D and influenza vaccination. Data pertaining to study population, vaccine components, vitamin D levels, and immunogenic response were analyzed. Nine studies, with a combined study population of 2367 patients, were included in the systematic review. Four studies were included in the meta-analysis to investigate the influence of vitamin D deficiency (VDD) on the seroprotection (SP) rates and seroconversion (SC) rates following influenza vaccination. We found no significant association between vitamin D level and the immunogenic response to influenza vaccination. However, strain-specific differences may exist. We observed lower SP rates of influenza A virus subtype H3N2 (A/H3N2) and B strain in VDD patients than patients with normal vitamin D levels (A/H3N2: 71.8% vs. 80.1%, odds ratio (OR): 0.63, 95% confidence interval (CI): 0.43-0.91, p = 0.01; B strain: 69.6% vs. 76.4%, OR: 0.68, 95% CI: 0.5-0.93, p = 0.01). However, the SP rates of A/H1N1 and SC rates of all three strains were not significantly different in VDD and control groups. In conclusion, no association was observed between VDD and immunogenic response to influenza vaccination.

Links

PMC Free PDF

Authors+Show Affiliations

Lee MD
Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 300, Taiwan. 4554@mmh.org.tw.
Lin CH
Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 300, Taiwan. 3099@mmh.org.tw.
Lei WT
Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 300, Taiwan. lazyleisure@gmail.com.
Chang HY
Department of Pediatrics, MacKay Children's Hospital, Taipei 104, Taiwan. drchy@seed.net.tw.
Lee HC
Department of Pediatrics, MacKay Children's Hospital, Taipei 104, Taiwan. ped2435@mmh.org.tw.
Yeung CY
Department of Pediatrics, MacKay Children's Hospital, Taipei 104, Taiwan. cy.yeung@mmh.org.tw.
Chiu NC
Department of Pediatrics, MacKay Children's Hospital, Taipei 104, Taiwan. ncc88@mmh.org.tw.
Chi H
Department of Pediatrics, MacKay Children's Hospital, Taipei 104, Taiwan. chi.4531@mmh.org.tw.
Liu JM
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan. mento1218@gmail.com. Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan. mento1218@gmail.com. Department of Medicine, National Yang-Ming University, Taipei 112, Taiwan. mento1218@gmail.com.
Hsu RJ
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan. hsurnai@gmail.com.
Cheng YJ
Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 300, Taiwan. 4569@mmh.org.tw.
Yeh TL
Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 300, Taiwan. 5767@mmh.org.tw.
Lin CY
Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 300, Taiwan. mmhped.lin@gmail.com.

MeSH

AdultAgedBiomarkersChi-Square DistributionChildChild, PreschoolFemaleHumansImmunogenicity, VaccineInfluenza VaccinesInfluenza, HumanInfluenzavirus AInfluenzavirus BMaleMiddle AgedOdds RatioRisk FactorsTreatment OutcomeVaccinationVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

29587438

Citation

Lee, Ming-Dar, et al. "Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? a Systematic Review and Meta-Analysis." Nutrients, vol. 10, no. 4, 2018.
Lee MD, Lin CH, Lei WT, et al. Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis. Nutrients. 2018;10(4).
Lee, M. D., Lin, C. H., Lei, W. T., Chang, H. Y., Lee, H. C., Yeung, C. Y., Chiu, N. C., Chi, H., Liu, J. M., Hsu, R. J., Cheng, Y. J., Yeh, T. L., & Lin, C. Y. (2018). Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis. Nutrients, 10(4). https://doi.org/10.3390/nu10040409
Lee MD, et al. Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? a Systematic Review and Meta-Analysis. Nutrients. 2018 Mar 26;10(4) PubMed PMID: 29587438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis. AU - Lee,Ming-Dar, AU - Lin,Chao-Hsu, AU - Lei,Wei-Te, AU - Chang,Hung-Yang, AU - Lee,Hung-Chang, AU - Yeung,Chun-Yan, AU - Chiu,Nan-Chang, AU - Chi,Hsin, AU - Liu,Jui-Ming, AU - Hsu,Ren-Jun, AU - Cheng,Yu-Jyun, AU - Yeh,Tzu-Lin, AU - Lin,Chien-Yu, Y1 - 2018/03/26/ PY - 2018/03/04/received PY - 2018/03/21/revised PY - 2018/03/21/accepted PY - 2018/3/29/entrez PY - 2018/3/29/pubmed PY - 2018/9/18/medline KW - 25(OH)D KW - calcitriol KW - human health KW - influenza KW - influenza vaccination KW - vitamin D JF - Nutrients JO - Nutrients VL - 10 IS - 4 N2 - Influenza virus infection is a major global public health problem, and the efficacy of influenza vaccination is not satisfactory. Vitamin D is involved in many immune-mediated inflammatory processes. The impact of vitamin D levels on the immunogenic response to influenza vaccination is not clear. We performed a comprehensive literature search and systematic review of studies that investigated vitamin D and influenza vaccination. Data pertaining to study population, vaccine components, vitamin D levels, and immunogenic response were analyzed. Nine studies, with a combined study population of 2367 patients, were included in the systematic review. Four studies were included in the meta-analysis to investigate the influence of vitamin D deficiency (VDD) on the seroprotection (SP) rates and seroconversion (SC) rates following influenza vaccination. We found no significant association between vitamin D level and the immunogenic response to influenza vaccination. However, strain-specific differences may exist. We observed lower SP rates of influenza A virus subtype H3N2 (A/H3N2) and B strain in VDD patients than patients with normal vitamin D levels (A/H3N2: 71.8% vs. 80.1%, odds ratio (OR): 0.63, 95% confidence interval (CI): 0.43-0.91, p = 0.01; B strain: 69.6% vs. 76.4%, OR: 0.68, 95% CI: 0.5-0.93, p = 0.01). However, the SP rates of A/H1N1 and SC rates of all three strains were not significantly different in VDD and control groups. In conclusion, no association was observed between VDD and immunogenic response to influenza vaccination. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29587438/Does_Vitamin_D_Deficiency_Affect_the_Immunogenic_Responses_to_Influenza_Vaccination_A_Systematic_Review_and_Meta_Analysis_ DB - PRIME DP - Unbound Medicine ER -