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Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review.
Respir Res 2018; 19(1):51RR

Abstract

INTRODUCTION

Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative stress is one of the main pathogenic pathways in IPF. The aim of this systematic review was to describe the type of markers of oxidative stress identified in different biological specimens and the effects of antioxidant therapies in patients with IPF.

METHODS

We conducted a systematic search of publications listed in electronic databases (Pubmed, Web of Science, Scopus and Google Scholar) from inception to October 2017. Two investigators independently reviewed all identified articles to determine eligibility.

RESULTS

After a substantial proportion of the initially identified articles (n = 554) was excluded because they were duplicates, abstracts, irrelevant, or did not meet the selection criteria, we identified 30 studies. In each study, we critically appraised the type, site (systemic vs. local, e.g. breath, sputum, expired breath condensate, epithelial lining fluid, bronchoalveolar lavage, and lung tissue specimens), and method used for measuring the identified oxidative stress biomarkers. Furthermore, the current knowledge on antioxidant therapies in IPF was summarized.

CONCLUSIONS

A number of markers of oxidative stress, with individual advantages and limitations, have been described in patients with IPF. Nevertheless, trials of antioxidant treatments have been unable to demonstrate consistent benefits, barring recent pharmacogenomics data suggesting different results in specific genotype subgroups of patients with IPF.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy. agfois@uniss.it. Department of Respiratory Diseases, University Hospital Sassari (AOU), Sassari, Italy. agfois@uniss.it.Department of Biomedical Sciences, University of Sassari, Sassari, Italy.Department of Biomedical Sciences, University of Sassari, Sassari, Italy.Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia.Department of Respiratory Diseases, University Hospital Sassari (AOU), Sassari, Italy.Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy. Department of Respiratory Diseases, University Hospital Sassari (AOU), Sassari, Italy.Department of Biomedical Sciences, University of Sassari, Sassari, Italy.Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

29587761

Citation

Fois, Alessandro G., et al. "Evaluation of Oxidative Stress Biomarkers in Idiopathic Pulmonary Fibrosis and Therapeutic Applications: a Systematic Review." Respiratory Research, vol. 19, no. 1, 2018, p. 51.
Fois AG, Paliogiannis P, Sotgia S, et al. Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review. Respir Res. 2018;19(1):51.
Fois, A. G., Paliogiannis, P., Sotgia, S., Mangoni, A. A., Zinellu, E., Pirina, P., ... Zinellu, A. (2018). Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review. Respiratory Research, 19(1), p. 51. doi:10.1186/s12931-018-0754-7.
Fois AG, et al. Evaluation of Oxidative Stress Biomarkers in Idiopathic Pulmonary Fibrosis and Therapeutic Applications: a Systematic Review. Respir Res. 2018 03 27;19(1):51. PubMed PMID: 29587761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review. AU - Fois,Alessandro G, AU - Paliogiannis,Panagiotis, AU - Sotgia,Salvatore, AU - Mangoni,Arduino A, AU - Zinellu,Elisabetta, AU - Pirina,Pietro, AU - Carru,Ciriaco, AU - Zinellu,Angelo, Y1 - 2018/03/27/ PY - 2017/12/07/received PY - 2018/03/19/accepted PY - 2018/3/29/entrez PY - 2018/3/29/pubmed PY - 2018/11/13/medline KW - Antioxidant KW - Idiopathic pulmonary fibrosis KW - Lung KW - Oxidant KW - Oxidative stress SP - 51 EP - 51 JF - Respiratory research JO - Respir. Res. VL - 19 IS - 1 N2 - INTRODUCTION: Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative stress is one of the main pathogenic pathways in IPF. The aim of this systematic review was to describe the type of markers of oxidative stress identified in different biological specimens and the effects of antioxidant therapies in patients with IPF. METHODS: We conducted a systematic search of publications listed in electronic databases (Pubmed, Web of Science, Scopus and Google Scholar) from inception to October 2017. Two investigators independently reviewed all identified articles to determine eligibility. RESULTS: After a substantial proportion of the initially identified articles (n = 554) was excluded because they were duplicates, abstracts, irrelevant, or did not meet the selection criteria, we identified 30 studies. In each study, we critically appraised the type, site (systemic vs. local, e.g. breath, sputum, expired breath condensate, epithelial lining fluid, bronchoalveolar lavage, and lung tissue specimens), and method used for measuring the identified oxidative stress biomarkers. Furthermore, the current knowledge on antioxidant therapies in IPF was summarized. CONCLUSIONS: A number of markers of oxidative stress, with individual advantages and limitations, have been described in patients with IPF. Nevertheless, trials of antioxidant treatments have been unable to demonstrate consistent benefits, barring recent pharmacogenomics data suggesting different results in specific genotype subgroups of patients with IPF. SN - 1465-993X UR - https://www.unboundmedicine.com/medline/citation/29587761/Evaluation_of_oxidative_stress_biomarkers_in_idiopathic_pulmonary_fibrosis_and_therapeutic_applications:_a_systematic_review_ L2 - https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-018-0754-7 DB - PRIME DP - Unbound Medicine ER -