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Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study.
Reprod Biol Endocrinol. 2018 Mar 27; 16(1):31.RB

Abstract

BACKGROUND

Osteopontin (OPN) plays an important role in inflammatory processes and insulin resistance. Polycystic ovary syndrome (PCOS) is a reproductive metabolic disease associated with insulin resistance and metabolic abnormalities, including high levels of liver fat content (LFC). The objective of this study was to explore whether circulating OPN independently contributes to elevated LFC in non-obese PCOS patients.

METHODS

This study included 61 non-obese PCOS patients and 56 age-matched healthy women from Shanghai, China. After an overnight fast, all participants underwent anthropometric measurements, oral glucose tolerance tests, lipid profile and sex hormone measurements. Quantitative measurement of LFC by ultrasonography was performed. OPN concentrations were measured using ELISA. An independent samples t-test and the Mann-Whitney U test were performed to compare variables between the two groups; one-way ANOVA and Kruskal-Wallis test were performed to compare four subgroups of patients. Correlations were determined by Spearman's correlation tests. Stepwise multiple linear regression analyses were performed to assess for independent contributors. A receiver operating characteristic curve with the maximum Youden index was calculated for the optimal cut-off value.

RESULTS

In non-obese PCOS women, circulating OPN levels were increased in the subgroups with a higher body mass index (BMI) and free androgen index (FAI), and the LFC levels were increased in the elevated OPN subgroups. Moreover, increased OPN was associated with increased FAI and LFC in PCOS women, and the association between OPN and LFC was independent of triglyceride, HOMA-IR and FAI after adjusting for PCOS status in all participants. OPN combined with FAI and hsCRP may better predict NAFLD than WHR in this study cohort. However, there was no significant difference in circulating OPN levels between non-obese PCOS and normal control women.

CONCLUSIONS

Increased OPN levels may be related to FAI and elevated LFC in non-obese women with PCOS.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China.Department of Emergency, South Campus, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.Division of Ultrasonography, Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China.Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China.Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China.Shanghai Key laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China.Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China. sue_liuwei@163.com. Shanghai Key laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China. sue_liuwei@163.com.Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China. taotaozhen@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29587769

Citation

Wang, Yuying, et al. "Circulating Osteopontin and Its Association With Liver Fat Content in Non-obese Women With Polycystic Ovary Syndrome: a Case Control Study." Reproductive Biology and Endocrinology : RB&E, vol. 16, no. 1, 2018, p. 31.
Wang Y, Zhou W, Wu C, et al. Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study. Reprod Biol Endocrinol. 2018;16(1):31.
Wang, Y., Zhou, W., Wu, C., Zhang, Y., Lin, T., Sun, Y., Liu, W., & Tao, T. (2018). Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study. Reproductive Biology and Endocrinology : RB&E, 16(1), 31. https://doi.org/10.1186/s12958-018-0331-4
Wang Y, et al. Circulating Osteopontin and Its Association With Liver Fat Content in Non-obese Women With Polycystic Ovary Syndrome: a Case Control Study. Reprod Biol Endocrinol. 2018 Mar 27;16(1):31. PubMed PMID: 29587769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study. AU - Wang,Yuying, AU - Zhou,Wei, AU - Wu,Chunhua, AU - Zhang,Yi, AU - Lin,Tzuchun, AU - Sun,Yun, AU - Liu,Wei, AU - Tao,Tao, Y1 - 2018/03/27/ PY - 2017/11/11/received PY - 2018/02/06/accepted PY - 2018/3/29/entrez PY - 2018/3/29/pubmed PY - 2018/9/12/medline KW - Hyperandrogenism KW - Liver fat content KW - Osteopontin KW - Polycystic ovary syndrome SP - 31 EP - 31 JF - Reproductive biology and endocrinology : RB&E JO - Reprod Biol Endocrinol VL - 16 IS - 1 N2 - BACKGROUND: Osteopontin (OPN) plays an important role in inflammatory processes and insulin resistance. Polycystic ovary syndrome (PCOS) is a reproductive metabolic disease associated with insulin resistance and metabolic abnormalities, including high levels of liver fat content (LFC). The objective of this study was to explore whether circulating OPN independently contributes to elevated LFC in non-obese PCOS patients. METHODS: This study included 61 non-obese PCOS patients and 56 age-matched healthy women from Shanghai, China. After an overnight fast, all participants underwent anthropometric measurements, oral glucose tolerance tests, lipid profile and sex hormone measurements. Quantitative measurement of LFC by ultrasonography was performed. OPN concentrations were measured using ELISA. An independent samples t-test and the Mann-Whitney U test were performed to compare variables between the two groups; one-way ANOVA and Kruskal-Wallis test were performed to compare four subgroups of patients. Correlations were determined by Spearman's correlation tests. Stepwise multiple linear regression analyses were performed to assess for independent contributors. A receiver operating characteristic curve with the maximum Youden index was calculated for the optimal cut-off value. RESULTS: In non-obese PCOS women, circulating OPN levels were increased in the subgroups with a higher body mass index (BMI) and free androgen index (FAI), and the LFC levels were increased in the elevated OPN subgroups. Moreover, increased OPN was associated with increased FAI and LFC in PCOS women, and the association between OPN and LFC was independent of triglyceride, HOMA-IR and FAI after adjusting for PCOS status in all participants. OPN combined with FAI and hsCRP may better predict NAFLD than WHR in this study cohort. However, there was no significant difference in circulating OPN levels between non-obese PCOS and normal control women. CONCLUSIONS: Increased OPN levels may be related to FAI and elevated LFC in non-obese women with PCOS. SN - 1477-7827 UR - https://www.unboundmedicine.com/medline/citation/29587769/Circulating_osteopontin_and_its_association_with_liver_fat_content_in_non_obese_women_with_polycystic_ovary_syndrome:_a_case_control_study_ L2 - https://rbej.biomedcentral.com/articles/10.1186/s12958-018-0331-4 DB - PRIME DP - Unbound Medicine ER -