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Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort.
Br J Nutr 2018; 119(10):1157-1167BJ

Abstract

There is growing evidence that intakes of high-fructose corn syrup (HFCS), HFCS-sweetened soda, fruit drinks and apple juice - a high-fructose 100 % juice - are associated with asthma, possibly because of the high fructose:glucose ratios and underlying fructose malabsorption, which may contribute to enteral formation of pro-inflammatory advanced glycation end products, which bind receptors that are mediators of asthma. Cox proportional hazards models were used to assess associations between intakes of these beverages and asthma risk, with data from the Framingham Offspring Cohort. Diet soda and orange juice - a 100 % juice with a 1:1 fructose:glucose ratio - were included for comparison. Increasing intake of any combination of HFCS-sweetened soda, fruit drinks and apple juice was significantly associated with progressively higher asthma risk, plateauing at 5-7 times/week v. never/seldom, independent of potential confounders (hazard ratio 1·91, P<0·001). About once a day consumers of HFCS-sweetened soda had a 49 % higher risk (P<0·011), moderate apple juice consumers (2-4 times/week) had a 61 % higher risk (P<0·007) and moderate fruit drink consumers had a 58 % higher risk (P<0·009), as compared with never/seldom consumers. There were no associations with diet soda/orange juice. These associations are possibly because of the high fructose:glucose ratios, and fructose malabsorption. Recommendations to reduce consumption may be inadequate to address asthma risk, as associations are evident even with moderate intake of these beverages, including apple juice - a 100 % juice. The juice reductions in the US Special Supplemental Nutrition Program for Women, Infants, and Children in 2009, and the plateauing/decreasing asthma prevalence (2010-2013), particularly among non-Hispanic black children, may be related. Further research regarding the consequences of fructose malabsorption is needed.

Authors+Show Affiliations

1Independent Researcher,Eugene, OR 97405,USA.2Department of Biomedical and Nutritional Sciences,University of Massachusetts Lowell,Lowell,MA 01854,USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29587887

Citation

DeChristopher, Luanne R., and Katherine L. Tucker. "Excess Free Fructose, High-fructose Corn Syrup and Adult Asthma: the Framingham Offspring Cohort." The British Journal of Nutrition, vol. 119, no. 10, 2018, pp. 1157-1167.
DeChristopher LR, Tucker KL. Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort. Br J Nutr. 2018;119(10):1157-1167.
DeChristopher, L. R., & Tucker, K. L. (2018). Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort. The British Journal of Nutrition, 119(10), pp. 1157-1167. doi:10.1017/S0007114518000417.
DeChristopher LR, Tucker KL. Excess Free Fructose, High-fructose Corn Syrup and Adult Asthma: the Framingham Offspring Cohort. Br J Nutr. 2018;119(10):1157-1167. PubMed PMID: 29587887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort. AU - DeChristopher,Luanne R, AU - Tucker,Katherine L, Y1 - 2018/03/28/ PY - 2018/3/29/pubmed PY - 2019/4/4/medline PY - 2018/3/29/entrez KW - AGE advanced glycation end products KW - CDC US Centers for Disease Control KW - EFF excess free fructose KW - FHS-OS Framingham Heart Study Original-Cohort Study KW - HFCS high-fructose corn syrup KW - HR hazard ratio KW - NHANES (US) National Health and Nutrition Examination Survey KW - SSB sugar-sweetened beverages KW - T2D type 2 diabetes KW - enFruAGE extracellular newly identified fructose associated advanced glycation end products KW - Apple juice KW - Excess free fructose KW - Fructositis KW - Fruit drinks KW - Glycation KW - High-fructose corn syrup KW - Receptor of advanced glycation endproducts SP - 1157 EP - 1167 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 119 IS - 10 N2 - There is growing evidence that intakes of high-fructose corn syrup (HFCS), HFCS-sweetened soda, fruit drinks and apple juice - a high-fructose 100 % juice - are associated with asthma, possibly because of the high fructose:glucose ratios and underlying fructose malabsorption, which may contribute to enteral formation of pro-inflammatory advanced glycation end products, which bind receptors that are mediators of asthma. Cox proportional hazards models were used to assess associations between intakes of these beverages and asthma risk, with data from the Framingham Offspring Cohort. Diet soda and orange juice - a 100 % juice with a 1:1 fructose:glucose ratio - were included for comparison. Increasing intake of any combination of HFCS-sweetened soda, fruit drinks and apple juice was significantly associated with progressively higher asthma risk, plateauing at 5-7 times/week v. never/seldom, independent of potential confounders (hazard ratio 1·91, P<0·001). About once a day consumers of HFCS-sweetened soda had a 49 % higher risk (P<0·011), moderate apple juice consumers (2-4 times/week) had a 61 % higher risk (P<0·007) and moderate fruit drink consumers had a 58 % higher risk (P<0·009), as compared with never/seldom consumers. There were no associations with diet soda/orange juice. These associations are possibly because of the high fructose:glucose ratios, and fructose malabsorption. Recommendations to reduce consumption may be inadequate to address asthma risk, as associations are evident even with moderate intake of these beverages, including apple juice - a 100 % juice. The juice reductions in the US Special Supplemental Nutrition Program for Women, Infants, and Children in 2009, and the plateauing/decreasing asthma prevalence (2010-2013), particularly among non-Hispanic black children, may be related. Further research regarding the consequences of fructose malabsorption is needed. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/29587887/Excess_free_fructose_high_fructose_corn_syrup_and_adult_asthma:_the_Framingham_Offspring_Cohort_ L2 - https://www.cambridge.org/core/product/identifier/S0007114518000417/type/journal_article DB - PRIME DP - Unbound Medicine ER -