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Intestinal resection-associated metabolic syndrome.
J Pediatr Surg. 2018 Jun; 53(6):1142-1147.JP

Abstract

BACKGROUND

Short bowel syndrome occurs following massive small bowel resection (SBR) and is one of the most lethal diseases of childhood. We have previously demonstrated hepatic steatosis, altered gut microbiome, and increased fat deposition in our murine model of SBR. These novel findings prompted us to investigate potential alterations in glucose metabolism and systemic inflammation following intestinal resection.

METHODS

Male C57BL6 mice underwent 50% proximal SBR or sham operation. Body weight and composition were measured. Fasting blood glucose (FBG), glucose, and insulin tolerance testing were performed. Small bowel, pancreas, and serum were collected at sacrifice and analyzed.

RESULTS

SBR mice gained less weight than shams after 10weeks. Despite this, FBG in resected mice was significantly higher than sham animals. After SBR, mice demonstrated perturbed body composition, higher blood glucose, increased pancreatic islet area, and increased systemic inflammation compared with sham mice. Despite these changes, we found no alteration in insulin tolerance after resection.

CONCLUSIONS

After massive SBR, we present evidence for abnormal body composition, glucose metabolism, and systemic inflammation. These findings, coupled with resection-associated hepatic steatosis, suggest that massive SBR (independent of parenteral nutrition) results in metabolic consequences not previously described and provides further evidence to support the presence of a novel resection-associated metabolic syndrome.

Links

Authors+Show Affiliations

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; St. Louis Children's Hospital, St. Louis, MO, USA.

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; St. Louis Children's Hospital, St. Louis, MO, USA.

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; St. Louis Children's Hospital, St. Louis, MO, USA.

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; St. Louis Children's Hospital, St. Louis, MO, USA.

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; St. Louis Children's Hospital, St. Louis, MO, USA.

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; St. Louis Children's Hospital, St. Louis, MO, USA.

Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; St. Louis Children's Hospital, St. Louis, MO, USA. Electronic address: Brad.Warner@wustl.edu.

MeSH

AnimalsBiomarkersIntestine, SmallMaleMetabolic SyndromeMiceMice, Inbred C57BLShort Bowel Syndrome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29588076

Citation

Barron, Lauren, et al. "Intestinal Resection-associated Metabolic Syndrome." Journal of Pediatric Surgery, vol. 53, no. 6, 2018, pp. 1142-1147.

Barron L, Courtney C, Bao J, et al. Intestinal resection-associated metabolic syndrome. J Pediatr Surg. 2018;53(6):1142-1147.

Barron, L., Courtney, C., Bao, J., Onufer, E., Panni, R. Z., Aladegbami, B., & Warner, B. W. (2018). Intestinal resection-associated metabolic syndrome. Journal of Pediatric Surgery, 53(6), 1142-1147. https://doi.org/10.1016/j.jpedsurg.2018.02.077

Barron L, et al. Intestinal Resection-associated Metabolic Syndrome. J Pediatr Surg. 2018;53(6):1142-1147. PubMed PMID: 29588076.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Intestinal resection-associated metabolic syndrome. AU - Barron,Lauren, AU - Courtney,Cathleen, AU - Bao,James, AU - Onufer,Emily, AU - Panni,Roheena Z, AU - Aladegbami,Bola, AU - Warner,Brad W, Y1 - 2018/03/07/ PY - 2018/02/14/received PY - 2018/02/27/accepted PY - 2018/3/29/pubmed PY - 2018/10/12/medline PY - 2018/3/29/entrez KW - Hepatic steatosis KW - Short bowel syndrome KW - Small bowel resection SP - 1142 EP - 1147 JF - Journal of pediatric surgery JO - J Pediatr Surg VL - 53 IS - 6 N2 - BACKGROUND: Short bowel syndrome occurs following massive small bowel resection (SBR) and is one of the most lethal diseases of childhood. We have previously demonstrated hepatic steatosis, altered gut microbiome, and increased fat deposition in our murine model of SBR. These novel findings prompted us to investigate potential alterations in glucose metabolism and systemic inflammation following intestinal resection. METHODS: Male C57BL6 mice underwent 50% proximal SBR or sham operation. Body weight and composition were measured. Fasting blood glucose (FBG), glucose, and insulin tolerance testing were performed. Small bowel, pancreas, and serum were collected at sacrifice and analyzed. RESULTS: SBR mice gained less weight than shams after 10weeks. Despite this, FBG in resected mice was significantly higher than sham animals. After SBR, mice demonstrated perturbed body composition, higher blood glucose, increased pancreatic islet area, and increased systemic inflammation compared with sham mice. Despite these changes, we found no alteration in insulin tolerance after resection. CONCLUSIONS: After massive SBR, we present evidence for abnormal body composition, glucose metabolism, and systemic inflammation. These findings, coupled with resection-associated hepatic steatosis, suggest that massive SBR (independent of parenteral nutrition) results in metabolic consequences not previously described and provides further evidence to support the presence of a novel resection-associated metabolic syndrome. SN - 1531-5037 UR - https://www.unboundmedicine.com/medline/citation/29588076/Intestinal_resection_associated_metabolic_syndrome_ DB - PRIME DP - Unbound Medicine ER -