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Primary Graft Dysfunction (PGD) Following Lung Transplantation.
Semin Respir Crit Care Med 2018; 39(2):148-154SR

Abstract

Primary graft dysfunction (PGD) is a form of acute lung injury that results from ischemia reperfusion injury (IRI) and is the major cause of early posttransplant morbidity and mortality. Patients who survive PGD have decreased quality of life, an increased risk of chronic lung allograft dysfunction, specifically bronchiolitis obliterans syndrome, and a significantly increased risk of death. In 2017, the International Society for Heart and Lung Transplantation released updated consensus statements on the PGD definition, most up-to-date PGD risk factors, mechanisms of PGD development, and the state-of-the-art for PGD therapeutics. Risk factor identification has led to the development of PGD predictive algorithms, although their clinical utility remains limited. Ongoing areas of controversy and discussion include further refinements to the PGD grading scheme to account for technologic advances such as extracorporeal membrane oxygenation and the increased utilization of high flow nasal cannula, the use of PGD as an outcome measure in clinical trials of ex vivo lung perfusion, enhancement of predictive algorithms incorporating biochemical risk factors, and the need for development of therapies targeted at improving PGD outcomes.

Authors+Show Affiliations

Division of Pulmonary, Allergy, and Critical Care, University of California, San Francisco, California.Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29590671

Citation

Shah, Rupal J., and Joshua M. Diamond. "Primary Graft Dysfunction (PGD) Following Lung Transplantation." Seminars in Respiratory and Critical Care Medicine, vol. 39, no. 2, 2018, pp. 148-154.
Shah RJ, Diamond JM. Primary Graft Dysfunction (PGD) Following Lung Transplantation. Semin Respir Crit Care Med. 2018;39(2):148-154.
Shah, R. J., & Diamond, J. M. (2018). Primary Graft Dysfunction (PGD) Following Lung Transplantation. Seminars in Respiratory and Critical Care Medicine, 39(2), pp. 148-154. doi:10.1055/s-0037-1615797.
Shah RJ, Diamond JM. Primary Graft Dysfunction (PGD) Following Lung Transplantation. Semin Respir Crit Care Med. 2018;39(2):148-154. PubMed PMID: 29590671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary Graft Dysfunction (PGD) Following Lung Transplantation. AU - Shah,Rupal J, AU - Diamond,Joshua M, Y1 - 2018/03/28/ PY - 2018/3/29/entrez PY - 2018/3/29/pubmed PY - 2019/1/10/medline SP - 148 EP - 154 JF - Seminars in respiratory and critical care medicine JO - Semin Respir Crit Care Med VL - 39 IS - 2 N2 - Primary graft dysfunction (PGD) is a form of acute lung injury that results from ischemia reperfusion injury (IRI) and is the major cause of early posttransplant morbidity and mortality. Patients who survive PGD have decreased quality of life, an increased risk of chronic lung allograft dysfunction, specifically bronchiolitis obliterans syndrome, and a significantly increased risk of death. In 2017, the International Society for Heart and Lung Transplantation released updated consensus statements on the PGD definition, most up-to-date PGD risk factors, mechanisms of PGD development, and the state-of-the-art for PGD therapeutics. Risk factor identification has led to the development of PGD predictive algorithms, although their clinical utility remains limited. Ongoing areas of controversy and discussion include further refinements to the PGD grading scheme to account for technologic advances such as extracorporeal membrane oxygenation and the increased utilization of high flow nasal cannula, the use of PGD as an outcome measure in clinical trials of ex vivo lung perfusion, enhancement of predictive algorithms incorporating biochemical risk factors, and the need for development of therapies targeted at improving PGD outcomes. SN - 1098-9048 UR - https://www.unboundmedicine.com/medline/citation/29590671/Primary_Graft_Dysfunction__PGD__Following_Lung_Transplantation_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0037-1615797 DB - PRIME DP - Unbound Medicine ER -