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Tree nut, peanut, and peanut butter consumption and the risk of gastric and esophageal cancer subtypes: the Netherlands Cohort Study.
Gastric Cancer 2018; 21(6):900-912GC

Abstract

BACKGROUND

Nut consumption has been associated with reduced cancer-related mortality. However, it is unclear whether nut consumption also reduces the risk of esophageal and gastric cancer subtypes. We prospectively investigated the relationship of tree nut, peanut, and peanut butter intake with risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA) in the Netherlands Cohort Study.

METHODS

In 1986, 120,852 males and females, aged 55-69 years, completed a baseline questionnaire on diet and cancer risk factors. After 20.3 years of follow-up, 133 ESCC, 200 EAC, 191 GCA, and 586 GNCA cases, and 3,720 subcohort members were available for multivariable Cox regression analyses, using a case-cohort approach.

RESULTS

Increased total nut consumption was significantly associated with a decreased risk of ESCC and GNCA [HRs (95% CIs) for 10 + g/day vs. nonconsumers = 0.54 (0.30-0.96) and 0.73 (0.55-0.97), respectively], but not with EAC and GCA risk. Similar trends were observed for tree nut and peanut intake, which were mostly nonsignificant. For peanut butter intake, no significant associations were found. When excluding the first four years of follow-up to reduce the possible influence of reversed causation, the relation between nut consumption and ESCC risk attenuated, but remained inverse.

CONCLUSIONS

Our findings suggest that increased tree nut and peanut consumption is inversely associated with GNCA risk and possibly with ESCC risk, but not with the risk of the other esophageal and gastric cancer subtypes.

Authors+Show Affiliations

Department of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Centre, Maastricht, The Netherlands. l.nieuwenhuis@maastrichtuniversity.nl.Department of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Centre, Maastricht, The Netherlands. Department of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29594821

Citation

Nieuwenhuis, Lisette, and Piet A. van den Brandt. "Tree Nut, Peanut, and Peanut Butter Consumption and the Risk of Gastric and Esophageal Cancer Subtypes: the Netherlands Cohort Study." Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, vol. 21, no. 6, 2018, pp. 900-912.
Nieuwenhuis L, van den Brandt PA. Tree nut, peanut, and peanut butter consumption and the risk of gastric and esophageal cancer subtypes: the Netherlands Cohort Study. Gastric Cancer. 2018;21(6):900-912.
Nieuwenhuis, L., & van den Brandt, P. A. (2018). Tree nut, peanut, and peanut butter consumption and the risk of gastric and esophageal cancer subtypes: the Netherlands Cohort Study. Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 21(6), pp. 900-912. doi:10.1007/s10120-018-0821-2.
Nieuwenhuis L, van den Brandt PA. Tree Nut, Peanut, and Peanut Butter Consumption and the Risk of Gastric and Esophageal Cancer Subtypes: the Netherlands Cohort Study. Gastric Cancer. 2018;21(6):900-912. PubMed PMID: 29594821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tree nut, peanut, and peanut butter consumption and the risk of gastric and esophageal cancer subtypes: the Netherlands Cohort Study. AU - Nieuwenhuis,Lisette, AU - van den Brandt,Piet A, Y1 - 2018/03/28/ PY - 2017/12/13/received PY - 2018/03/15/accepted PY - 2018/3/30/pubmed PY - 2019/1/27/medline PY - 2018/3/30/entrez KW - Chemoprevention KW - Cohort studies KW - Esophageal neoplasms KW - Nuts KW - Stomach neoplasms SP - 900 EP - 912 JF - Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association JO - Gastric Cancer VL - 21 IS - 6 N2 - BACKGROUND: Nut consumption has been associated with reduced cancer-related mortality. However, it is unclear whether nut consumption also reduces the risk of esophageal and gastric cancer subtypes. We prospectively investigated the relationship of tree nut, peanut, and peanut butter intake with risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA) in the Netherlands Cohort Study. METHODS: In 1986, 120,852 males and females, aged 55-69 years, completed a baseline questionnaire on diet and cancer risk factors. After 20.3 years of follow-up, 133 ESCC, 200 EAC, 191 GCA, and 586 GNCA cases, and 3,720 subcohort members were available for multivariable Cox regression analyses, using a case-cohort approach. RESULTS: Increased total nut consumption was significantly associated with a decreased risk of ESCC and GNCA [HRs (95% CIs) for 10 + g/day vs. nonconsumers = 0.54 (0.30-0.96) and 0.73 (0.55-0.97), respectively], but not with EAC and GCA risk. Similar trends were observed for tree nut and peanut intake, which were mostly nonsignificant. For peanut butter intake, no significant associations were found. When excluding the first four years of follow-up to reduce the possible influence of reversed causation, the relation between nut consumption and ESCC risk attenuated, but remained inverse. CONCLUSIONS: Our findings suggest that increased tree nut and peanut consumption is inversely associated with GNCA risk and possibly with ESCC risk, but not with the risk of the other esophageal and gastric cancer subtypes. SN - 1436-3305 UR - https://www.unboundmedicine.com/medline/citation/29594821/Tree_nut_peanut_and_peanut_butter_consumption_and_the_risk_of_gastric_and_esophageal_cancer_subtypes:_the_Netherlands_Cohort_Study_ L2 - http://dx.doi.org/10.1007/s10120-018-0821-2 DB - PRIME DP - Unbound Medicine ER -