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Assembly of ER-PM Junctions: A Critical Determinant in the Regulation of SOCE and TRPC1.
Adv Exp Med Biol. 2017; 981:253-276.AE

Abstract

Store-operated calcium entry (SOCE), a unique plasma membrane Ca2+ entry mechanism, is activated when ER-[Ca2+] is decreased. SOCE is mediated via the primary channel, Orai1, as well as others such as TRPC1. STIM1 and STIM2 are ER-Ca2+ sensor proteins that regulate Orai1 and TRPC1. SOCE requires assembly of STIM proteins with the plasma membrane channels which occurs within distinct regions in the cell that have been termed as endoplasmic reticulum (ER)-plasma membrane (PM) junctions. The PM and ER are in close proximity to each other within this region, which allows STIM1 in the ER to interact with and activate either Orai1 or TRPC1 in the plasma membrane. Activation and regulation of SOCE involves dynamic assembly of various components that are involved in mediating Ca2+ entry as well as those that determine the formation and stabilization of the junctions. These components include proteins in the cytosol, ER and PM, as well as lipids in the PM. Recent studies have also suggested that SOCE and its components are compartmentalized within ER-PM junctions and that this process might require remodeling of the plasma membrane lipids and reorganization of structural and scaffolding proteins. Such compartmentalization leads to the generation of spatially- and temporally-controlled Ca2+signals that are critical for regulating many downstream cellular functions.

Authors+Show Affiliations

Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda, MD, USA.Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda, MD, USA.Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda, MD, USA. indu.ambudkar@nih.gov.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29594865

Citation

Subedi, Krishna P., et al. "Assembly of ER-PM Junctions: a Critical Determinant in the Regulation of SOCE and TRPC1." Advances in Experimental Medicine and Biology, vol. 981, 2017, pp. 253-276.
Subedi KP, Ong HL, Ambudkar IS. Assembly of ER-PM Junctions: A Critical Determinant in the Regulation of SOCE and TRPC1. Adv Exp Med Biol. 2017;981:253-276.
Subedi, K. P., Ong, H. L., & Ambudkar, I. S. (2017). Assembly of ER-PM Junctions: A Critical Determinant in the Regulation of SOCE and TRPC1. Advances in Experimental Medicine and Biology, 981, 253-276. https://doi.org/10.1007/978-3-319-55858-5_11
Subedi KP, Ong HL, Ambudkar IS. Assembly of ER-PM Junctions: a Critical Determinant in the Regulation of SOCE and TRPC1. Adv Exp Med Biol. 2017;981:253-276. PubMed PMID: 29594865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assembly of ER-PM Junctions: A Critical Determinant in the Regulation of SOCE and TRPC1. AU - Subedi,Krishna P, AU - Ong,Hwei Ling, AU - Ambudkar,Indu S, PY - 2018/3/30/entrez PY - 2017/1/1/pubmed PY - 2018/8/15/medline KW - ER-PM junctions KW - Orai1 KW - SOCE KW - STIM1 KW - STIM2 KW - TRPC1 SP - 253 EP - 276 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 981 N2 - Store-operated calcium entry (SOCE), a unique plasma membrane Ca2+ entry mechanism, is activated when ER-[Ca2+] is decreased. SOCE is mediated via the primary channel, Orai1, as well as others such as TRPC1. STIM1 and STIM2 are ER-Ca2+ sensor proteins that regulate Orai1 and TRPC1. SOCE requires assembly of STIM proteins with the plasma membrane channels which occurs within distinct regions in the cell that have been termed as endoplasmic reticulum (ER)-plasma membrane (PM) junctions. The PM and ER are in close proximity to each other within this region, which allows STIM1 in the ER to interact with and activate either Orai1 or TRPC1 in the plasma membrane. Activation and regulation of SOCE involves dynamic assembly of various components that are involved in mediating Ca2+ entry as well as those that determine the formation and stabilization of the junctions. These components include proteins in the cytosol, ER and PM, as well as lipids in the PM. Recent studies have also suggested that SOCE and its components are compartmentalized within ER-PM junctions and that this process might require remodeling of the plasma membrane lipids and reorganization of structural and scaffolding proteins. Such compartmentalization leads to the generation of spatially- and temporally-controlled Ca2+signals that are critical for regulating many downstream cellular functions. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/29594865/Assembly_of_ER_PM_Junctions:_A_Critical_Determinant_in_the_Regulation_of_SOCE_and_TRPC1_ L2 - https://dx.doi.org/10.1007/978-3-319-55858-5_11 DB - PRIME DP - Unbound Medicine ER -