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Blood flow in the foot, polyneuropathy and foot ulceration in diabetes mellitus.
Diabetologia. 1987 Jul; 30(7):468-73.D

Abstract

Comparable groups of diabetic patients asymptomatic of neuropathy (Group A), with chronic painful polyneuropathy (Group B) and painless polyneuropathy causing recurrent foot ulceration (Group C) were studied for differences in pedal blood flow, peripheral somatic and autonomic neuropathy and vascular calcification. Blood flow abnormalities detected by doppler waveform analysis, and consistent with reduced peripheral vascular resistance, were found in all three diabetic patient groups. The abnormalities were of similar severity in Group A and B but generally more marked in Group C. Tests of peripheral somatic nerve function became progressively more abnormal from Group A to Group C. Autonomic neuropathy was equally severe in Groups B and C, although mild abnormalities were recorded in diabetic patients asymptomatic of neuropathy. A similar pattern was seen for vascular calcification in the tarsal and metatarsal arteries: marked in both neuropathic groups (B and C) but mild in Group A. It was concluded that abnormal blood flow consistent with reduced peripheral vascular resistance is very common in the feet of diabetic patients whether or not they are symptomatic of neuropathy, and is most severe in those with chronic painless polyneuropathy and recurrent foot ulceration. No clear relationship was found between autonomic nerve dysfunction and the degree of abnormality of blood flow.

Authors+Show Affiliations

Corbin DO
Peripheral Vascular Clinic, Royal Infirmary, Edinburgh, Scotland.
Young RJ
No affiliation info available
Morrison DC
No affiliation info available
Hoskins P
No affiliation info available
McDicken WN
No affiliation info available
Housley E
No affiliation info available
Clarke BF
No affiliation info available

MeSH

AdultAngiographyDiabetes ComplicationsDiabetes MellitusDiabetic NeuropathiesFemaleFootFoot DiseasesHumansMaleMiddle AgedPeripheral NervesRegional Blood FlowRheologySkin UlcerVascular Resistance

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2959582

Citation

Corbin, D O., et al. "Blood Flow in the Foot, Polyneuropathy and Foot Ulceration in Diabetes Mellitus." Diabetologia, vol. 30, no. 7, 1987, pp. 468-73.
Corbin DO, Young RJ, Morrison DC, et al. Blood flow in the foot, polyneuropathy and foot ulceration in diabetes mellitus. Diabetologia. 1987;30(7):468-73.
Corbin, D. O., Young, R. J., Morrison, D. C., Hoskins, P., McDicken, W. N., Housley, E., & Clarke, B. F. (1987). Blood flow in the foot, polyneuropathy and foot ulceration in diabetes mellitus. Diabetologia, 30(7), 468-73.
Corbin DO, et al. Blood Flow in the Foot, Polyneuropathy and Foot Ulceration in Diabetes Mellitus. Diabetologia. 1987;30(7):468-73. PubMed PMID: 2959582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood flow in the foot, polyneuropathy and foot ulceration in diabetes mellitus. AU - Corbin,D O, AU - Young,R J, AU - Morrison,D C, AU - Hoskins,P, AU - McDicken,W N, AU - Housley,E, AU - Clarke,B F, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 468 EP - 73 JF - Diabetologia JO - Diabetologia VL - 30 IS - 7 N2 - Comparable groups of diabetic patients asymptomatic of neuropathy (Group A), with chronic painful polyneuropathy (Group B) and painless polyneuropathy causing recurrent foot ulceration (Group C) were studied for differences in pedal blood flow, peripheral somatic and autonomic neuropathy and vascular calcification. Blood flow abnormalities detected by doppler waveform analysis, and consistent with reduced peripheral vascular resistance, were found in all three diabetic patient groups. The abnormalities were of similar severity in Group A and B but generally more marked in Group C. Tests of peripheral somatic nerve function became progressively more abnormal from Group A to Group C. Autonomic neuropathy was equally severe in Groups B and C, although mild abnormalities were recorded in diabetic patients asymptomatic of neuropathy. A similar pattern was seen for vascular calcification in the tarsal and metatarsal arteries: marked in both neuropathic groups (B and C) but mild in Group A. It was concluded that abnormal blood flow consistent with reduced peripheral vascular resistance is very common in the feet of diabetic patients whether or not they are symptomatic of neuropathy, and is most severe in those with chronic painless polyneuropathy and recurrent foot ulceration. No clear relationship was found between autonomic nerve dysfunction and the degree of abnormality of blood flow. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/2959582/Blood_flow_in_the_foot_polyneuropathy_and_foot_ulceration_in_diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -