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Matrix metalloproteinase-9 expression of GCTSC in peripheral tissue and central tissue of GCTB.
J Cell Biochem. 2018 07; 119(7):5805-5812.JC

Abstract

Giant cell tumor stromal cell (GCTSC) is the tumor cell of giant cell tumor of bone (GCTB). The biomarkers characterization of GCTSC is critical for the selection of GCTB targeting drugs. We believe the main functions of GCTSC in different part of tumor should be different for different environment. Then the biological behavior and molecular biomarkers of GCTSC should be different as well. Based on this idea, we focused on GCTSC which located in central tissue, peripheral tissue and took MMP-9 as the breakthrough point to carry out research. The results showed MMP-9 staining grade of GCTSC which located in central tissue was slight, whereas multinucleated giant cell staining grade was high. The peripheral tissue was consisted by almost GCTSC with high MMP-9 staining degree and mRNA expression. This study also provided clues and inspiration for reducing GCTB recurrence rate after intralesional curettage with MMP-9 targeted therapy which were aimed at the residual peripheral tissue.

Authors+Show Affiliations

Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29600575

Citation

Chen, Liang, et al. "Matrix Metalloproteinase-9 Expression of GCTSC in Peripheral Tissue and Central Tissue of GCTB." Journal of Cellular Biochemistry, vol. 119, no. 7, 2018, pp. 5805-5812.
Chen L, Zhang J, He Y, et al. Matrix metalloproteinase-9 expression of GCTSC in peripheral tissue and central tissue of GCTB. J Cell Biochem. 2018;119(7):5805-5812.
Chen, L., Zhang, J., He, Y., & Ding, X. Y. (2018). Matrix metalloproteinase-9 expression of GCTSC in peripheral tissue and central tissue of GCTB. Journal of Cellular Biochemistry, 119(7), 5805-5812. https://doi.org/10.1002/jcb.26766
Chen L, et al. Matrix Metalloproteinase-9 Expression of GCTSC in Peripheral Tissue and Central Tissue of GCTB. J Cell Biochem. 2018;119(7):5805-5812. PubMed PMID: 29600575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix metalloproteinase-9 expression of GCTSC in peripheral tissue and central tissue of GCTB. AU - Chen,Liang, AU - Zhang,Ji, AU - He,Yifeng, AU - Ding,Xiao-Yi, Y1 - 2018/03/30/ PY - 2017/09/17/received PY - 2018/02/02/accepted PY - 2018/3/31/pubmed PY - 2019/5/9/medline PY - 2018/3/31/entrez KW - MMP-9 KW - RT-PCR KW - giant cell tumor of bone KW - immunohistochemistry SP - 5805 EP - 5812 JF - Journal of cellular biochemistry JO - J. Cell. Biochem. VL - 119 IS - 7 N2 - Giant cell tumor stromal cell (GCTSC) is the tumor cell of giant cell tumor of bone (GCTB). The biomarkers characterization of GCTSC is critical for the selection of GCTB targeting drugs. We believe the main functions of GCTSC in different part of tumor should be different for different environment. Then the biological behavior and molecular biomarkers of GCTSC should be different as well. Based on this idea, we focused on GCTSC which located in central tissue, peripheral tissue and took MMP-9 as the breakthrough point to carry out research. The results showed MMP-9 staining grade of GCTSC which located in central tissue was slight, whereas multinucleated giant cell staining grade was high. The peripheral tissue was consisted by almost GCTSC with high MMP-9 staining degree and mRNA expression. This study also provided clues and inspiration for reducing GCTB recurrence rate after intralesional curettage with MMP-9 targeted therapy which were aimed at the residual peripheral tissue. SN - 1097-4644 UR - https://www.unboundmedicine.com/medline/citation/29600575/Matrix_metalloproteinase_9_expression_of_GCTSC_in_peripheral_tissue_and_central_tissue_of_GCTB_ L2 - https://doi.org/10.1002/jcb.26766 DB - PRIME DP - Unbound Medicine ER -