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[Exploring Chinese medicine and Western medicine group modules in acute phase of ischemic stroke disease].
Zhongguo Zhong Yao Za Zhi. 2018 Feb; 43(3):618-626.ZZ

Abstract

Under the theoretical guidance of "combination of disease and syndrome, correspondence between syndrome and prescription, and dynamic space-time", 11 135 acute ischemic stroke patients were collected from hospital information system(HIS) of many 3A grade hospitals of traditional Chinese medicine. Complex network analysis was adopted to obtain the core syndrome elements in different periods of acute ischemic stroke patients, and it was found that the core syndrome elements were blood stasis syndrome, phlegm, endogenous wind, Yin deficiency, Qi deficiency, heat, hyperactivity of liver Yang, liver, and kidney of patients in hospital for the first day, and during 8-14 d in hospitalization, the core syndrome elements were blood stasis, phlegm, Yin deficiency, Qi deficiency, endogenous wind, hyperactivity of liver Yang, liver, and kidney. The data with "improved" and "cured" treatment outcomes were adopted for complex network analysis and correlation analysis to identify the Chinese and Western medicine group modules in patients with different disease conditions in different phases after hospitalization. It was found that the Chinese and Western medicine modules within 14 d after hospitalization mainly included "blood-activating and stasis-dissolving module "consisted by "anti-platelet drug + circulation-improving medicine(or anticoagulant drug and anti-fibrinogen drug, et al) + blood-activating and stasis-dissolving drugs", as well as "stasis-dissolving and phlegm-reducing module" consisted by "anti-platelet drugs + circulation-improving medicine(or anticoagulant drug and anti-fibrinogen drug, et al) + phlegm refreshing drug". The core Chinese and Western medicine modules in patients with urgent and general conditions within 7 d after hospitalization mainly used "blood-activating and stasis-dissolving module" and "stasis-dissolving and phlegm-reducing module". Three or more Chinese medicine and Western medicines module with more than 1% utilization rate was not found in the patients with critical disease condition in admission. The urgent, general and critically ill patients in admission mainly used "blood-activating and stasis-dissolving module" in 8-14 d. From the real world medical big data research, it was found that the combined use of Chinese and Western medicines were consistent with "combination of disease and syndrome, correspondence between syndrome and prescription, and dynamic space-time" theory, and multiple multidimensional dynamic Chinese medicine and Western medicine group modules of "patient-syndrome-drug-time-effective" at the acute ischemic stroke stage were dug out, forming the method of Chinese and Western medicine combination research based on electrical medical big data.

Authors+Show Affiliations

The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China.Institute of Systems Engineering, Dalian University of Technology, Dalian 116024, China.Institute of Systems Engineering, Dalian University of Technology, Dalian 116024, China.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Systems Engineering, Dalian University of Technology, Dalian 116024, China.Computer Management Center, Navy General Hospital, Beijing 100048, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29600631

Citation

Yang, Wei, et al. "[Exploring Chinese Medicine and Western Medicine Group Modules in Acute Phase of Ischemic Stroke Disease]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 43, no. 3, 2018, pp. 618-626.
Yang W, Li MQ, Li Y, et al. [Exploring Chinese medicine and Western medicine group modules in acute phase of ischemic stroke disease]. Zhongguo Zhong Yao Za Zhi. 2018;43(3):618-626.
Yang, W., Li, M. Q., Li, Y., Sun, L. L., Xie, Y. M., Guo, C. H., & Zhuang, Y. (2018). [Exploring Chinese medicine and Western medicine group modules in acute phase of ischemic stroke disease]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 43(3), 618-626. https://doi.org/10.19540/j.cnki.cjcmm.20171211.001
Yang W, et al. [Exploring Chinese Medicine and Western Medicine Group Modules in Acute Phase of Ischemic Stroke Disease]. Zhongguo Zhong Yao Za Zhi. 2018;43(3):618-626. PubMed PMID: 29600631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Exploring Chinese medicine and Western medicine group modules in acute phase of ischemic stroke disease]. AU - Yang,Wei, AU - Li,Ming-Quan, AU - Li,Yang, AU - Sun,Lei-Lei, AU - Xie,Yan-Ming, AU - Guo,Chong-Hui, AU - Zhuang,Yan, PY - 2017/05/03/received PY - 2018/3/31/entrez PY - 2018/3/31/pubmed PY - 2019/7/11/medline KW - Chinese and Western medicine group module KW - complex network KW - electronic medical records KW - hospital information system KW - the acute phase of ischemic stroke SP - 618 EP - 626 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 43 IS - 3 N2 - Under the theoretical guidance of "combination of disease and syndrome, correspondence between syndrome and prescription, and dynamic space-time", 11 135 acute ischemic stroke patients were collected from hospital information system(HIS) of many 3A grade hospitals of traditional Chinese medicine. Complex network analysis was adopted to obtain the core syndrome elements in different periods of acute ischemic stroke patients, and it was found that the core syndrome elements were blood stasis syndrome, phlegm, endogenous wind, Yin deficiency, Qi deficiency, heat, hyperactivity of liver Yang, liver, and kidney of patients in hospital for the first day, and during 8-14 d in hospitalization, the core syndrome elements were blood stasis, phlegm, Yin deficiency, Qi deficiency, endogenous wind, hyperactivity of liver Yang, liver, and kidney. The data with "improved" and "cured" treatment outcomes were adopted for complex network analysis and correlation analysis to identify the Chinese and Western medicine group modules in patients with different disease conditions in different phases after hospitalization. It was found that the Chinese and Western medicine modules within 14 d after hospitalization mainly included "blood-activating and stasis-dissolving module "consisted by "anti-platelet drug + circulation-improving medicine(or anticoagulant drug and anti-fibrinogen drug, et al) + blood-activating and stasis-dissolving drugs", as well as "stasis-dissolving and phlegm-reducing module" consisted by "anti-platelet drugs + circulation-improving medicine(or anticoagulant drug and anti-fibrinogen drug, et al) + phlegm refreshing drug". The core Chinese and Western medicine modules in patients with urgent and general conditions within 7 d after hospitalization mainly used "blood-activating and stasis-dissolving module" and "stasis-dissolving and phlegm-reducing module". Three or more Chinese medicine and Western medicines module with more than 1% utilization rate was not found in the patients with critical disease condition in admission. The urgent, general and critically ill patients in admission mainly used "blood-activating and stasis-dissolving module" in 8-14 d. From the real world medical big data research, it was found that the combined use of Chinese and Western medicines were consistent with "combination of disease and syndrome, correspondence between syndrome and prescription, and dynamic space-time" theory, and multiple multidimensional dynamic Chinese medicine and Western medicine group modules of "patient-syndrome-drug-time-effective" at the acute ischemic stroke stage were dug out, forming the method of Chinese and Western medicine combination research based on electrical medical big data. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/29600631/[Exploring_Chinese_medicine_and_Western_medicine_group_modules_in_acute_phase_of_ischemic_stroke_disease]_ L2 - http://www.diseaseinfosearch.org/result/8683 DB - PRIME DP - Unbound Medicine ER -