Tags

Type your tag names separated by a space and hit enter

Ten-Year Progression of Myopic Maculopathy: The Beijing Eye Study 2001-2011.
Ophthalmology. 2018 08; 125(8):1253-1263.O

Abstract

PURPOSE

To investigate the progression pattern of myopic maculopathy and associated factors in a population-based study.

DESIGN

Population-based longitudinal study.

PARTICIPANTS

The Beijing Eye Study including 4439 participants in 2001 was repeated in 2011, with 2695 individuals (66.4%) being re-examined in 2011.

METHODS

The study participants underwent detailed ophthalmic and general examinations. Using fundus photographs obtained in 2001 and 2011, we assessed the progression of myopic maculopathy in highly myopic eyes with a refractive error ≥-6 diopters in 2001. Myopic maculopathy was differentiated into tessellated fundus (category 1), diffuse chorioretinal atrophy (category 2), patchy chorioretinal atrophy (category 3), and macular atrophy (category 4), with lacquer cracks and choroidal neovascularization as additional plus signs.

MAIN OUTCOME MEASURES

Progression pattern of myopic maculopathy.

RESULTS

Of 110 highly myopic eyes (70 individuals) at baseline, 39 eyes (35.5%) showed progression observed in 15 of 79 eyes (19%) with tessellated fundus at baseline, in 17 of 24 eyes (71%) with diffuse chorioretinal atrophy, in all 6 eyes with patchy chorioretinal atrophy, and the 1 eye with macular atrophy. Lacquer cracks detected in 2 eyes in 2001 developed into a small patchy atrophy (1 eye) or widened during the follow-up (1 eye). Five eyes demonstrated new lacquer cracks. In binary regression analysis, progression of myopic maculopathy was associated with longer axial length (P < 0.001; odds ratio [OR], 7.13; 95% confidence interval [CI], 2.49-20.4), older age (P = 0.001; OR, 1.25; 95% CI, 1.10-1.42), higher prevalence of staphylomas (P = 0.03; OR, 24.3; 95% CI, 2.89-204), smaller parapapillary γ-zone in 2011 (P = 0.01; OR, 0.61; 95% CI, 0.41-0.91), and female gender (P = 0.04; OR, 9.78; 95% CI, 1.06-90.6).

CONCLUSIONS

The 10-year progression rate of myopic maculopathy in this elderly Chinese population was 35.5%, increasing from 15 of 79 eyes (19%) in category 1 of myopic maculopathy at baseline to 17 of 24 eyes (71%) in category 2 and 6 of 6 eyes (100%) in category 3. Risk factors for myopic maculopathy progression were longer axial length, pre-existing staphylomata, smaller parapapillary γ-zone, older age, and female gender.

Authors+Show Affiliations

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Institute of Ophthalmology and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Aier-Intech Eye Hospital, Beijing, China.Beijing Institute of Ophthalmology and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Institute of Ophthalmology and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address: tr_weiwenbin@163.com.Beijing Institute of Ophthalmology and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Seegartenklinik, Heidelberg, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29602569

Citation

Yan, Yan Ni, et al. "Ten-Year Progression of Myopic Maculopathy: the Beijing Eye Study 2001-2011." Ophthalmology, vol. 125, no. 8, 2018, pp. 1253-1263.
Yan YN, Wang YX, Yang Y, et al. Ten-Year Progression of Myopic Maculopathy: The Beijing Eye Study 2001-2011. Ophthalmology. 2018;125(8):1253-1263.
Yan, Y. N., Wang, Y. X., Yang, Y., Xu, L., Xu, J., Wang, Q., Yang, J. Y., Yang, X., Zhou, W. J., Ohno-Matsui, K., Wei, W. B., & Jonas, J. B. (2018). Ten-Year Progression of Myopic Maculopathy: The Beijing Eye Study 2001-2011. Ophthalmology, 125(8), 1253-1263. https://doi.org/10.1016/j.ophtha.2018.01.035
Yan YN, et al. Ten-Year Progression of Myopic Maculopathy: the Beijing Eye Study 2001-2011. Ophthalmology. 2018;125(8):1253-1263. PubMed PMID: 29602569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ten-Year Progression of Myopic Maculopathy: The Beijing Eye Study 2001-2011. AU - Yan,Yan Ni, AU - Wang,Ya Xing, AU - Yang,Yan, AU - Xu,Liang, AU - Xu,Jie, AU - Wang,Qian, AU - Yang,Jing Yan, AU - Yang,Xuan, AU - Zhou,Wen Jia, AU - Ohno-Matsui,Kyoko, AU - Wei,Wen Bin, AU - Jonas,Jost B, Y1 - 2018/03/27/ PY - 2017/10/20/received PY - 2018/01/05/revised PY - 2018/01/25/accepted PY - 2018/4/1/pubmed PY - 2019/9/7/medline PY - 2018/4/1/entrez SP - 1253 EP - 1263 JF - Ophthalmology JO - Ophthalmology VL - 125 IS - 8 N2 - PURPOSE: To investigate the progression pattern of myopic maculopathy and associated factors in a population-based study. DESIGN: Population-based longitudinal study. PARTICIPANTS: The Beijing Eye Study including 4439 participants in 2001 was repeated in 2011, with 2695 individuals (66.4%) being re-examined in 2011. METHODS: The study participants underwent detailed ophthalmic and general examinations. Using fundus photographs obtained in 2001 and 2011, we assessed the progression of myopic maculopathy in highly myopic eyes with a refractive error ≥-6 diopters in 2001. Myopic maculopathy was differentiated into tessellated fundus (category 1), diffuse chorioretinal atrophy (category 2), patchy chorioretinal atrophy (category 3), and macular atrophy (category 4), with lacquer cracks and choroidal neovascularization as additional plus signs. MAIN OUTCOME MEASURES: Progression pattern of myopic maculopathy. RESULTS: Of 110 highly myopic eyes (70 individuals) at baseline, 39 eyes (35.5%) showed progression observed in 15 of 79 eyes (19%) with tessellated fundus at baseline, in 17 of 24 eyes (71%) with diffuse chorioretinal atrophy, in all 6 eyes with patchy chorioretinal atrophy, and the 1 eye with macular atrophy. Lacquer cracks detected in 2 eyes in 2001 developed into a small patchy atrophy (1 eye) or widened during the follow-up (1 eye). Five eyes demonstrated new lacquer cracks. In binary regression analysis, progression of myopic maculopathy was associated with longer axial length (P < 0.001; odds ratio [OR], 7.13; 95% confidence interval [CI], 2.49-20.4), older age (P = 0.001; OR, 1.25; 95% CI, 1.10-1.42), higher prevalence of staphylomas (P = 0.03; OR, 24.3; 95% CI, 2.89-204), smaller parapapillary γ-zone in 2011 (P = 0.01; OR, 0.61; 95% CI, 0.41-0.91), and female gender (P = 0.04; OR, 9.78; 95% CI, 1.06-90.6). CONCLUSIONS: The 10-year progression rate of myopic maculopathy in this elderly Chinese population was 35.5%, increasing from 15 of 79 eyes (19%) in category 1 of myopic maculopathy at baseline to 17 of 24 eyes (71%) in category 2 and 6 of 6 eyes (100%) in category 3. Risk factors for myopic maculopathy progression were longer axial length, pre-existing staphylomata, smaller parapapillary γ-zone, older age, and female gender. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/29602569/Ten_Year_Progression_of_Myopic_Maculopathy:_The_Beijing_Eye_Study_2001_2011_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(17)33236-0 DB - PRIME DP - Unbound Medicine ER -