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Further efficacy studies on inactivated, aluminum-hydroxide-adsorbed vaccines against infectious coryza.
Avian Dis 1987 Jul-Sep; 31(3):527-32AD

Abstract

Specific-pathogen-free chickens were given infectious coryza vaccines containing inactivated cells of Haemophilus paragallinarum adsorbed onto an aluminum-hydroxide gel. The vaccines were protective when given subcutaneously or intramuscularly but not when given intranasally. Vaccines prepared with two different commercial brands of aluminum-hydroxide gel gave similar protection. Vaccines in which the inactivating agent was thimerosal were more protective than similar vaccines in which the inactivating agent was formalin. Monovalent vaccines protected against challenge only from organisms of the same agglutination serovar, whereas bivalent vaccines protected against challenge from organisms of either serovar. A single dose of the vaccine, given at 16 weeks of age, was not as effective as two doses given at 12 and 16 weeks of age in protecting against challenge 12, 25, or 56 weeks after vaccination.

Authors+Show Affiliations

Queensland Department of Primary Industries, Animal Research Institute, Yeerongpilly, Australia.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2960312

Citation

Blackall, P J., and G G. Reid. "Further Efficacy Studies On Inactivated, Aluminum-hydroxide-adsorbed Vaccines Against Infectious Coryza." Avian Diseases, vol. 31, no. 3, 1987, pp. 527-32.
Blackall PJ, Reid GG. Further efficacy studies on inactivated, aluminum-hydroxide-adsorbed vaccines against infectious coryza. Avian Dis. 1987;31(3):527-32.
Blackall, P. J., & Reid, G. G. (1987). Further efficacy studies on inactivated, aluminum-hydroxide-adsorbed vaccines against infectious coryza. Avian Diseases, 31(3), pp. 527-32.
Blackall PJ, Reid GG. Further Efficacy Studies On Inactivated, Aluminum-hydroxide-adsorbed Vaccines Against Infectious Coryza. Avian Dis. 1987;31(3):527-32. PubMed PMID: 2960312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further efficacy studies on inactivated, aluminum-hydroxide-adsorbed vaccines against infectious coryza. AU - Blackall,P J, AU - Reid,G G, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 527 EP - 32 JF - Avian diseases JO - Avian Dis. VL - 31 IS - 3 N2 - Specific-pathogen-free chickens were given infectious coryza vaccines containing inactivated cells of Haemophilus paragallinarum adsorbed onto an aluminum-hydroxide gel. The vaccines were protective when given subcutaneously or intramuscularly but not when given intranasally. Vaccines prepared with two different commercial brands of aluminum-hydroxide gel gave similar protection. Vaccines in which the inactivating agent was thimerosal were more protective than similar vaccines in which the inactivating agent was formalin. Monovalent vaccines protected against challenge only from organisms of the same agglutination serovar, whereas bivalent vaccines protected against challenge from organisms of either serovar. A single dose of the vaccine, given at 16 weeks of age, was not as effective as two doses given at 12 and 16 weeks of age in protecting against challenge 12, 25, or 56 weeks after vaccination. SN - 0005-2086 UR - https://www.unboundmedicine.com/medline/citation/2960312/Further_efficacy_studies_on_inactivated_aluminum_hydroxide_adsorbed_vaccines_against_infectious_coryza_ L2 - https://medlineplus.gov/haemophilusinfections.html DB - PRIME DP - Unbound Medicine ER -