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Oral Candida colonization and plaque type psoriasis: Is there any relationship?
J Investig Clin Dent. 2018 Aug; 9(3):e12335.JI

Abstract

AIM

The potential role of superantigens derived from microbial agents could be considered in the pathogenesis of psoriasis, but the association between Candida albicans and psoriasis severity is still controversial. The present study was designed to compare the prevalence of oral candidiasis in a group of psoriatic patients and healthy patients, and its correlation with psoriasis severity.

METHODS

Seventy psoriatic patients with no history of systemic treatment and 70 closely-matched control patients underwent oral examination. Scraping of oral mucosa to detect Candida species was done using a sterile cytobrush.

RESULTS

Candida was detected in the oral cavity of 20% of patients with psoriasis and 2.8% of control cases (P = .002), but none had clinical features of oral candidiasis. Candida albicans was the only species isolated from the oral cavity of both groups. No correlation was found between sex, age, phototherapy, and presence of oral candidiasis. There was a positive correlation between psoriasis severity and colony count (P < .001).

CONCLUSIONS

The prevalence of oral candidiasis is higher in psoriatic patients and is associated with disease severity. It is not exactly clear whether oral candidiasis can aggravate psoriasis or if psoriasis can predispose patients to oral candidiasis.

Authors+Show Affiliations

Department of Oral Disease and Diagnosis, Islamic Azad University, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Oral Disease and Diagnosis, Islamic Azad University, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29603683

Citation

Lesan, Simin, et al. "Oral Candida Colonization and Plaque Type Psoriasis: Is There Any Relationship?" Journal of Investigative and Clinical Dentistry, vol. 9, no. 3, 2018, pp. e12335.
Lesan S, Toosi R, Aliakbarzadeh R, et al. Oral Candida colonization and plaque type psoriasis: Is there any relationship? J Investig Clin Dent. 2018;9(3):e12335.
Lesan, S., Toosi, R., Aliakbarzadeh, R., Daneshpazhooh, M., Mahmoudi, L., Tavakolpour, S., & Mahmoudi, H. (2018). Oral Candida colonization and plaque type psoriasis: Is there any relationship? Journal of Investigative and Clinical Dentistry, 9(3), e12335. https://doi.org/10.1111/jicd.12335
Lesan S, et al. Oral Candida Colonization and Plaque Type Psoriasis: Is There Any Relationship. J Investig Clin Dent. 2018;9(3):e12335. PubMed PMID: 29603683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral Candida colonization and plaque type psoriasis: Is there any relationship? AU - Lesan,Simin, AU - Toosi,Roja, AU - Aliakbarzadeh,Reza, AU - Daneshpazhooh,Maryam, AU - Mahmoudi,Leila, AU - Tavakolpour,Soheil, AU - Mahmoudi,Hamidreza, Y1 - 2018/03/30/ PY - 2017/12/09/received PY - 2018/02/01/accepted PY - 2018/4/1/pubmed PY - 2019/2/7/medline PY - 2018/4/1/entrez KW - candida albicans KW - colony count KW - oral candidiasis KW - psoriasis KW - psoriasis area and severity index SP - e12335 EP - e12335 JF - Journal of investigative and clinical dentistry JO - J Investig Clin Dent VL - 9 IS - 3 N2 - AIM: The potential role of superantigens derived from microbial agents could be considered in the pathogenesis of psoriasis, but the association between Candida albicans and psoriasis severity is still controversial. The present study was designed to compare the prevalence of oral candidiasis in a group of psoriatic patients and healthy patients, and its correlation with psoriasis severity. METHODS: Seventy psoriatic patients with no history of systemic treatment and 70 closely-matched control patients underwent oral examination. Scraping of oral mucosa to detect Candida species was done using a sterile cytobrush. RESULTS: Candida was detected in the oral cavity of 20% of patients with psoriasis and 2.8% of control cases (P = .002), but none had clinical features of oral candidiasis. Candida albicans was the only species isolated from the oral cavity of both groups. No correlation was found between sex, age, phototherapy, and presence of oral candidiasis. There was a positive correlation between psoriasis severity and colony count (P < .001). CONCLUSIONS: The prevalence of oral candidiasis is higher in psoriatic patients and is associated with disease severity. It is not exactly clear whether oral candidiasis can aggravate psoriasis or if psoriasis can predispose patients to oral candidiasis. SN - 2041-1626 UR - https://www.unboundmedicine.com/medline/citation/29603683/Oral_Candida_colonization_and_plaque_type_psoriasis:_Is_there_any_relationship L2 - https://doi.org/10.1111/jicd.12335 DB - PRIME DP - Unbound Medicine ER -